EKS-ICT-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	461.8	6.0E-139	1068	1326	259

Status

Unreviewed

Ensembl Protein

ENSSTOP00000004005

UniProt Accession

I3M4A6;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000004445	ENSSTOP00000004005	ENSSTOT00000004462

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1385

Protein Sequence
(FASTA)

LLLLLTAVSM SYRDWQCPRT PYAASRDFDV KYVVPSFFAG SQVQALATYE GSGDGSAVFV 60

ATRNHLHVLG PNLQSIESLA TGPTGDPGCQ TCAACGRGPH GPPVDTDTLV LVLEPVLPAL 120

VSCGSSLQGR CFLHELEMRG TTLHLAAPIC LFSAHNNRPE DCPDCVASPL GTRVTVVEQG 180

QASYFYVASS LDAKVATSFS PGSVSIRRLK ADASGFEPGF SSLSVLPKYL DSYHIEYVHS 240

FHAGAFVYLL TVQPSSVIDS PGALQTRLAR LNALEADLSD YRELVLDCHF APKRRRRGIP 300

DREQSYPILQ AAHSASVGTQ LAAELSITEG NEVLFGVFTT GRNGSPGMGP NSVVCAFPIN 360

LLDTLIDEGV EHCCESSVHS GLPRGLDFFQ SPSFCPNPPV LEASSPNISC HHFPLLVSRR 420

FPRVDLFNGL LGSVQVTALY VTRLDNVTVA HMGTSDGRIL QVELVRSLNY LLYVSNFSLS 480

NNGQSIHRDV KRLGDHLLFA SGDQVFQVPI QGPGCHHFLT CRRCLQAQHF MGCGWCGNMC 540

GRQKECPGSW QQDHCPPVLT KFYPDSGPLR GSTKLTLCGS NFYLHPTGLI PEGTHQVTVG 600

QSPCRLLPKD TSNLSPVPRK DFVEELECEL DPLGTQAAGT TNITLIVTNM PRGKHFQVEG 660

ISMLEGFSFV EPVLKRVQPL FGPRAGGTCL TLEGQGLSVG TSRAVLVNGT QCQLKRVSQG 720

QILCATPPGA ATARVPLRLQ VGGAEVPGSW TFHYQEDPIV LNISPNCGYP GSHVTIHGQY 780

LTSAWHLVLS FHDGQGTVEN RCEGQFPEQH QCRLPEYVVR GHQEWVTGNL SAWGDGAAGF 840

TLPGFRFLPP PRLPSAELAP LKPEEHTIKF EYIGLGAVAD CVSVNVTVGG ESCQHEFRGD 900

VVVCPLPTYL QLGKDGAPLQ VCVDGECHIL GRVVQPGVPQ NTLLIVLLAL LLLMASMATV 960

LVFNYWWRRK QLVLSPNLDD LASLDRTNGP TLLPMLHLGS DYRHGPELSA IDSPDSTTRV 1020

HAESFLDNRD GSCVPLLRTE SIKLRDLDSA LLAEVKDVLI PHERVITHSD RVIGKGHFGV 1080

VYHGEYTDEA QNRIHCAIKS LNRITEVQEV EAFLREGLLM RGLHHPNVLA LIGIMLPPEG 1140

LPRVLLPYMR HGDLLQFIRS PQRNPTVKDL ISFGLQVARG MEYLSEQKFV HRDLAARNCM 1200

LDESFTVKVA DFGLARDVLD KEYYSVQQQR HARLPVKWMA LESLQTYRFT TKSDVWSFGV 1260

LLWELLTRGA PPYPHIDPFD LIHFLAQGRR LPQPEYCPNS LYQVMQQCWE VDPAARPTFG 1320

ALVVEVEQVV ASLLGDHYVQ LSAAYVNLGP CALDEMNVLP EQLQSPSVHR SMLRPRPLSE 1380

PPLPT 1385

Nucleotide Sequence
(FASTA)

CTGCTATTGC TGCTGACTGC GGTGTCGATG TCATACAGGG ACTGGCAGTG CCCTCGCACA 60

CCCTACGCTG CTTCCCGCGA CTTTGATGTG AAGTATGTAG TGCCCAGCTT CTTTGCTGGC 120

AGCCAGGTAC AGGCCTTGGC CACCTATGAG GGCAGCGGGG ATGGGAGTGC GGTGTTTGTG 180

GCCACACGCA ATCACCTGCA TGTGCTTGGG CCTAACCTGC AGTCTATTGA GAGTCTGGCC 240

ACTGGCCCTA CCGGGGATCC TGGCTGTCAG ACATGTGCGG CCTGTGGCCG CGGCCCCCAT 300

GGCCCACCAG TTGACACAGA CACACTGGTG CTGGTTCTGG AGCCGGTGTT GCCAGCACTG 360

GTCAGCTGTG GCTCAAGCCT ACAAGGCCGC TGCTTTCTGC ATGAGCTGGA GATGCGCGGG 420

ACAACCCTGC ACCTGGCAGC GCCTATCTGC CTTTTCTCAG CCCATAACAA CCGGCCTGAG 480

GATTGTCCGG ACTGTGTGGC CAGCCCATTG GGCACCCGTG TGACAGTGGT TGAGCAGGGC 540

CAGGCCTCCT ACTTCTATGT GGCATCCTCA CTGGATGCAA AGGTGGCTAC CAGCTTTAGC 600

CCTGGCTCAG TGTCCATCCG GCGCCTCAAG GCAGATGCCT CAGGATTCGA ACCAGGCTTT 660

TCCTCATTGT CAGTGCTGCC AAAATATTTG GACTCCTACC ATATAGAATA TGTTCATAGC 720

TTCCATGCAG GAGCCTTTGT TTACCTGCTC ACTGTTCAGC CTTCCAGTGT GATAGACTCT 780

CCTGGTGCCC TGCAAACCCG CCTGGCACGG CTCAATGCCT TGGAGGCAGA TTTGAGTGAC 840

TACCGAGAAC TGGTCCTTGA CTGTCATTTT GCACCTAAAC GTCGGCGCCG TGGGATCCCA 900

GACCGGGAGC AGTCCTACCC GATCCTTCAG GCAGCCCACT CTGCTTCAGT GGGCACCCAA 960

CTCGCTGCTG AGCTGAGTAT CACCGAGGGC AATGAAGTGC TATTTGGAGT CTTCACCACT 1020

GGCAGGAATG GCAGTCCTGG CATGGGTCCC AACTCTGTTG TCTGTGCCTT TCCCATCAAC 1080

CTGCTGGACA CCCTAATTGA TGAGGGTGTG GAACACTGTT GTGAGTCCTC AGTTCATTCT 1140

GGCCTCCCAC GAGGCCTTGA CTTCTTCCAG TCGCCCAGTT TTTGCCCTAA CCCGCCTGTC 1200

CTGGAAGCTT CTAGCCCCAA CATCAGCTGC CACCACTTCC CTCTGCTGGT CAGCCGCAGG 1260

TTCCCACGTG TGGATCTATT CAATGGGCTG TTAGGATCAG TGCAGGTCAC TGCACTTTAT 1320

GTGACACGCC TTGACAATGT CACAGTGGCC CACATGGGCA CATCTGATGG GCGTATCCTA 1380

CAGGTGGAGC TAGTCAGATC ACTCAACTAC TTGCTGTATG TATCCAACTT CTCATTGAGT 1440

AACAACGGAC AGTCCATCCA TCGAGATGTC AAACGCCTTG GAGACCACCT ACTTTTTGCC 1500

TCTGGGGACC AGGTCTTCCA GGTACCTATC CAGGGGCCTG GCTGCCACCA TTTCCTCACT 1560

TGTAGGCGTT GCCTACAAGC ACAGCATTTC ATGGGCTGTG GCTGGTGTGG GAACATGTGC 1620

GGCAGACAGA AGGAGTGTCC TGGCTCCTGG CAACAAGATC ACTGTCCACC TGTGCTTACC 1680

AAGTTTTACC CTGACAGTGG ACCCCTAAGG GGCAGCACAA AGCTGACCCT GTGTGGCTCT 1740

AACTTCTACC TGCATCCTAC TGGTCTTATA CCTGAGGGAA CACATCAGGT CACTGTGGGC 1800

CAAAGTCCCT GCCGCCTGCT GCCTAAGGAC ACCTCAAACC TCAGTCCAGT GCCCCGGAAG 1860

GACTTTGTAG AGGAACTTGA GTGTGAGCTG GACCCCTTGG GCACACAGGC AGCAGGAACT 1920

ACCAACATCA CCCTTATCGT GACTAATATG CCACGGGGAA AGCACTTCCA GGTAGAAGGC 1980

ATCTCCATGC TGGAAGGCTT CTCTTTTGTG GAGCCAGTGC TGAAAAGAGT ACAACCCCTG 2040

TTTGGCCCAC GGGCAGGGGG CACCTGTCTC ACTCTTGAAG GCCAGGGCCT GTCTGTAGGC 2100

ACCAGCCGGG CTGTGTTGGT CAATGGAACC CAGTGCCAGT TGAAACGGGT CAGCCAGGGG 2160

CAGATTTTAT GTGCCACACC CCCTGGGGCT GCCACGGCCA GAGTACCCCT TCGCCTGCAG 2220

GTGGGAGGTG CTGAGGTGCC TGGCTCCTGG ACCTTCCACT ACCAGGAAGA CCCCATTGTG 2280

CTGAACATCA GCCCTAACTG TGGATACCCA GGCTCCCATG TCACTATCCA TGGCCAGTAT 2340

CTGACTTCAG CATGGCACTT AGTGCTATCA TTCCATGATG GGCAAGGAAC AGTGGAGAAC 2400

AGGTGTGAGG GGCAATTTCC AGAGCAGCAT CAATGCCGCC TGCCTGAATA TGTGGTCCGA 2460

GGCCACCAGG AGTGGGTAAC AGGAAATCTG AGTGCCTGGG GGGATGGAGC TGCTGGCTTC 2520

ACACTACCAG GCTTTCGCTT CCTACCCCCA CCCCGTCTAC CCAGTGCTGA ACTAGCCCCA 2580

CTGAAGCCTG AAGAGCATAC TATTAAGTTT GAGTATATTG GGTTGGGTGC TGTGGCTGAC 2640

TGCGTGAGTG TGAACGTGAC CGTGGGTGGT GAGAGCTGCC AGCACGAGTT CCGGGGGGAC 2700

GTGGTGGTCT GTCCCCTGCC CACCTACCTA CAACTTGGCA AGGATGGAGC CCCATTGCAG 2760

GTTTGCGTGG ATGGTGAGTG TCATATCCTT GGCAGAGTGG TGCAGCCAGG GGTCCCACAG 2820

AACACACTCC TTATTGTCTT GCTCGCCTTG CTGTTGCTCA TGGCTTCAAT GGCCACTGTG 2880

CTAGTTTTCA ACTACTGGTG GCGGAGGAAA CAATTGGTTC TTTCTCCCAA CCTTGATGAC 2940

CTGGCATCCC TGGACCGGAC CAATGGACCC ACGCTCCTGC CTATGCTCCA CTTAGGCTCT 3000

GACTATAGAC ATGGCCCTGA ACTCTCTGCT ATTGATAGTC CTGATTCTAC CACTCGGGTC 3060

CATGCAGAAT CCTTTTTGGA CAACAGAGAT GGGTCCTGTG TCCCACTGCT GCGGACAGAG 3120

TCCATTAAGC TCAGGGACCT GGACTCTGCA CTCCTGGCTG AGGTCAAGGA TGTACTGATC 3180

CCCCATGAGC GTGTAATCAC CCACAGTGAT CGAGTCATTG GCAAAGGCCA CTTTGGAGTT 3240

GTCTACCATG GAGAATACAC AGATGAGGCT CAGAATCGTA TCCACTGTGC CATCAAGTCG 3300

CTGAATCGCA TCACAGAGGT TCAGGAAGTA GAAGCCTTCT TGCGAGAGGG ACTGCTCATG 3360

CGCGGCCTGC ACCATCCAAA TGTTCTGGCT CTCATTGGTA TCATGCTGCC ACCTGAGGGG 3420

CTTCCCCGTG TGCTGTTGCC CTATATGCGC CATGGAGACC TGCTTCAGTT CATCCGGTCA 3480

CCTCAGCGGA ACCCCACTGT GAAGGACCTC ATCAGCTTTG GCCTGCAGGT AGCCCGAGGC 3540

ATGGAGTACC TATCAGAGCA GAAGTTTGTA CACAGGGACC TGGCTGCTCG GAACTGCATG 3600

CTGGATGAAT CATTCACAGT AAAGGTGGCT GACTTTGGTC TGGCCCGTGA TGTCCTGGAC 3660

AAGGAGTACT ACAGTGTTCA GCAGCAACGC CATGCTCGCT TACCTGTCAA GTGGATGGCA 3720

TTGGAAAGCC TTCAGACCTA TCGATTTACC ACCAAGTCTG ATGTGTGGTC ATTTGGTGTG 3780

CTGCTGTGGG AACTGCTGAC ACGGGGTGCC CCACCATACC CCCACATTGA CCCTTTTGAC 3840

CTCATTCATT TCCTGGCCCA GGGTCGGCGT CTGCCCCAGC CTGAGTATTG TCCCAATTCT 3900

CTGTATCAAG TAATGCAACA ATGCTGGGAG GTGGACCCGG CAGCACGACC TACCTTTGGA 3960

GCACTAGTGG TGGAAGTAGA ACAGGTAGTG GCCTCACTGC TTGGGGACCA CTATGTGCAG 4020

CTGTCTGCAG CCTATGTGAA TCTGGGTCCC TGTGCATTGG ATGAAATGAA TGTGCTTCCA 4080

GAACAGCTTC AATCCCCATC TGTGCACAGG AGCATGTTGA GGCCCCGGCC CCTCTCAGAG 4140

CCACCTTTGC CCACTTGA 4158

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         ++++viGkGhfGvvy+ge++d+a+++i++a+ksl+rit++++ve+flregl+m++l+hpn

Q: 1068  HSDRVIGKGHFGVVYHGEYTDEAQNRIHCAIKSLNRITEVQEVEAFLREGLLMRGLHHPN  1127

         7899********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vl+l+Gi+l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyl+++

Q: 1128  VLALIGIMLPPEGLPRVLLPYMRHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLSEQ  1187

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlardvldke+y+v+++r+arlpvkw+aleslqt+

Q: 1188  KFVHRDLAARNCMLDESFTVKVADFGLARDVLDKEYYSVQQQRHARLPVKWMALESLQTY  1247

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         + fttksdvwsfGvllwelltrga+py+++++fdl+++l++grrl++peycp++ly+vm+

Q: 1248  R-FTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLIHFLAQGRRLPQPEYCPNSLYQVMQ  1306

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsii  261

         +cw+ +pa+rp+f  lv  +

Q: 1307  QCWEVDPAARPTFGALVVEV  1326

         **************999765

Domain Sequence
(FASTA)

HSDRVIGKGH FGVVYHGEYT DEAQNRIHCA IKSLNRITEV QEVEAFLREG LLMRGLHHPN 60

VLALIGIMLP PEGLPRVLLP YMRHGDLLQF IRSPQRNPTV KDLISFGLQV ARGMEYLSEQ 120

KFVHRDLAAR NCMLDESFTV KVADFGLARD VLDKEYYSVQ QQRHARLPVK WMALESLQTY 180

RFTTKSDVWS FGVLLWELLT RGAPPYPHID PFDLIHFLAQ GRRLPQPEYC PNSLYQVMQQ 240

CWEVDPAARP TFGALVVEV 259

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013