EKS-ICT-00102
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00102
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec488.53.4E-147402652251
StatusUnreviewed
Ensembl ProteinENSSTOP00000004260
UniProt AccessionI3M4T4;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000004722ENSSTOP00000004260ENSSTOT00000004745
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length659
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTMHKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180
HRKTKKPLPP TPEEDQILKK PLPPEPTAAP VSPGELKKVV ALYDYMPMNA NDLQLRKGDE 240
YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360
YHQHNSAGLI SRLKYPVSQK NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420
WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480
CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540
GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FNNSETAEHI AKGLRLYRPH LASERVYTIM YSCWHEKADE RPTFKILLSN ILDVMDEES 659
Nucleotide Sequence
(FASTA)
ATGGCTGCAG TGATACTGGA GAGTATCTTT TTGAAGCGCT CACAGCAAAA AAAGAAAACA 60
TCGCCTTTAA ACTTCAAGAA GCGTCTCTTT CTCTTGACTA TGCACAAACT TTCCTACTAT 120
GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAAAAG 180
ATCACCTGCG TCGAAACAGT GGTTCCTGAA AAAAATCCTC CCCCTGAAAG ACAAATTCCG 240
AGAAGAGGTG AAGAGTCCAG TGAAATGGAA CAGATTTCAA TCATTGAAAG ATTTCCTTAT 300
CCTTTCCAGG TTGTATATGA TGAAGGGCCT CTCTATGTCT TTTCCCCAAC TGAAGAACTG 360
AGAAAGCGTT GGATTCATCA GCTCAAAAAT GTAATCCGAT ACAACAGTGA TCTGGTACAG 420
AAATACCACC CTTGCTTCTG GATCGATGGG CAGTATCTTT GCTGCTCTCA GACAGCCAAA 480
AATGCCATGG GCTGCCAAAT ATTGGAGAAC AGGAATGGAA GCTTAAAACC TGGGAGTTCT 540
CACCGAAAGA CAAAAAAGCC TCTTCCCCCC ACACCAGAGG AGGACCAGAT CTTGAAAAAG 600
CCACTGCCCC CTGAGCCAAC AGCAGCACCA GTCTCCCCGG GAGAGCTGAA AAAGGTTGTG 660
GCCCTTTATG ATTATATGCC AATGAATGCA AATGACCTAC AGCTGAGGAA GGGTGATGAG 720
TATTTTATCC TGGAGGAGAG CAACCTACCA TGGTGGCGAG CACGAGATAA AAATGGGCAG 780
GAAGGCTACA TTCCTAGTAA TTACGTCACT GAAGCAGAAG ACTCCATAGA AATGTATGAG 840
TGGTATTCCA AACACATGAC TCGGAGTCAA GCTGAGCAAC TACTAAAGCA AGAGGGGAAA 900
GAAGGAGGTT TCATTGTCAG AGACTCGAGC AAAGCTGGAA AATATACTGT GTCTGTGTTT 960
GCTAAATCTA CAGGGGACCC TCAAGGGGTG ATACGCCATT ATGTTGTGTG TTCCACACCT 1020
CAGAGCCAGT ATTACCTGGC TGAGAAACAC CTTTTCAGCA CCATTCCTGA GCTCATTAAT 1080
TACCATCAGC ATAACTCTGC CGGACTCATA TCTAGGCTGA AATATCCAGT GTCTCAGAAA 1140
AACAAGAATG CACCTTCCAC TGCAGGCCTG GGCTACGGAT CATGGGAAAT CGATCCAAAG 1200
GACCTGACTT TCTTGAAGGA GCTTGGAACT GGACAATTTG GAGTAGTAAA GTATGGGAAA 1260
TGGAGAGGTC AGTATGATGT GGCCATCAAG ATGATCAAAG AAGGCTCCAT GTCTGAAGAT 1320
GAGTTCATTG AAGAAGCCAA AGTCATGATG AATCTTTCCC ATGAGAAGCT GGTGCAGTTG 1380
TATGGCGTCT GCACCAAACA ACGCCCCATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440
TGCCTCCTGA ACTACCTGAG GGAGATGCGC CACCGCTTCC AGACTCAGCA GCTGCTGGAG 1500
ATGTGCAAAG ATGTCTGTGA AGCCATGGAA TACCTGGAGT CAAAGCAGTT CCTTCACCGA 1560
GACCTGGCAG CTCGAAACTG TTTGGTAAAT GATCAAGGAG TTGTGAAAGT ATCTGACTTT 1620
GGCCTGTCCA GATATGTCCT GGATGATGAG TACACCAGCT CAGTAGGCTC TAAATTTCCA 1680
GTACGGTGGT CTCCACCAGA AGTCCTTATG TATAGCAAGT TCAGCAGCAA ATCTGACATT 1740
TGGGCTTTTG GGGTTTTAAT GTGGGAAATT TACTCCCTTG GGAAAATGCC ATATGAGAGA 1800
TTTAATAACA GTGAGACTGC TGAACATATT GCCAAAGGCC TACGTCTCTA TAGGCCTCAT 1860
CTGGCTTCAG AGAGGGTATA TACCATTATG TATAGTTGCT GGCATGAGAA AGCAGATGAA 1920
CGTCCCACTT TCAAAATTCT CCTGAGCAAC ATTCTAGATG TTATGGATGA AGAATCTTGA 1980
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly
Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  461
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er
Q: 582   AFGVLMWEIYSLGKMPYERFNNSETAEHIAKGLRLYRPHLASERVYTIMYSCWHEKADER  641
         ************************************************************
S: 241   ptfkellsale  251
         ptfk lls++ 
Q: 642   PTFKILLSNIL  652
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF NNSETAEHIA KGLRLYRPHL ASERVYTIMY SCWHEKADER 240
PTFKILLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CII-00053
EKS-CIS-00119
EKS-DAR-00355
EKS-DRM-00050
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-TUT-00096
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013