EKS-ICT-00326

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00326

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	450.9	1.2E-135	127	385	259

Status

Unreviewed

Ensembl Protein

ENSSTOP00000004283

UniProt Accession

I3M4U6;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2

Gene Synonyms/Alias

TNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000004761	ENSSTOP00000004283	ENSSTOT00000004770

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1054

Protein Sequence
(FASTA)

MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 60

EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK PSPTPGGPVG EGPLQSLTCL 120

IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 180

MHSLDHRNLI RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 240

GYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 300

SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 360

YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 420

ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 480

KIDELYLGNP MDPPDLLSVE LSTSRPTQHL GRVKREPPPR PPQPAIFTQK PTYDPVSEDQ 540

DLLSGDFKRL GLRKPGLPRG LWLSKPSARV PGTKAGRSSG GEVTLIDFGE EPVIPASRPC 600

APSLAQLAMD ACSLLDKTPP QSPTRALPRP LHPTPVVDWD ARPLPPPPTY DDVAQDEDDF 660

EVCSINSTLV GAGLPTGPRQ GETNYGFVPE QARLPAALED NLFLPPQGGG KPPSLAQTSE 720

IFQALQQECM RQLQVPTGSL APSPSPGADD KPQVPPRVPI PPRPTRPRVE LSPAPSGEEE 780

IGRWPGPASP PRIPPREPLS PQGSRTPSPL VPPGGSPLPP RLSSSPGKTM PTTQSFASDP 840

KYATPQVIQA PGPRTGPCIL PIVRDGKKVS NTHYYLLPER PPYLERYQRY LREAQSPEEP 900

APLPVPLLLP PPSTPAPAAP TATVRPMPQA APDPKANFST NNSNLGTRPP SLRATARLPQ 960

RGCPGDGPEA GRPSDKIQML QAMVHGVTTE ECQTALQSHS WSVQRAAQYL KVEQLFGLGL 1020

WPRLECHKVL EMFDWNLEQA GCHLLGSCGP AHHK 1054

Nucleotide Sequence
(FASTA)

ATGCAGCCAG AGGAGGGCAC AGGCTGGTTG CTGGAGTTGC TGTCTGAGGT GCAGCTACAG 60

CAATACTTCC TTCGTCTTCG GGATGACCTC AATGTTACCC GTTTGTCCCA CTTTGAATAT 120

GTTAAGAATG AGGACCTGGA GAAGATTGGC ATGGGCCGGC CTGGCCAACG GCGGCTGTGG 180

GAAGCTGTGA AGAGAAGGAA AGCCATGTGC AAACGCAAGT CCTGGATGAG TAAGGTATTC 240

AGTGGAAAGC GGCTGGAGGC TGAGTTTCCC CCTCACCACT CTCAGAGCAC CTTCCGGAAA 300

CCCTCGCCCA CCCCAGGGGG TCCAGTGGGC GAGGGGCCCC TGCAAAGCCT CACCTGCCTC 360

ATTGGGGAGA AGGACCTGCG CCTCCTTGAG AAGCTGGGAG ATGGCTCCTT TGGCGTAGTG 420

CGCAGGGGCG AGTGGGATGC CCCTGCAGGG AAGACGGTGA GTGTGGCTGT AAAGTGCCTG 480

AAGCCGGATG TGCTGAGCCA GCCAGAGGCC ATGGACGACT TCATCCGGGA AGTCAATGCC 540

ATGCATTCAC TTGACCACCG AAATCTCATT CGCCTCTATG GTGTGGTGCT TACACCACCC 600

ATGAAGATGG TGACAGAGCT GGCACCTCTG GGATCTTTGT TGGACAGACT ACGTAAGCAT 660

CAGGGTCACT TCCTCCTGGG GACTCTGAGC CGCTATGCTG TGCAGGTGGC TGAAGGCATG 720

GGCTACCTGG AGTCCAAGCG CTTTATTCAC CGTGATCTGG CTGCCCGAAA TCTGCTATTG 780

GCTACCCGTG ACTTGGTCAA GATTGGGGAC TTTGGACTGA TGCGAGCACT ACCCCAAAAT 840

GATGACCACT ACGTCATGCA GGAACATCGC AAGGTGCCCT TTGCCTGGTG TGCCCCTGAA 900

AGCCTGAAGA CACGTACTTT TTCCCATGCC AGTGACACCT GGATGTTTGG GGTTACGTTG 960

TGGGAGATGT TCACCTATGG CCAGGAGCCC TGGATTGGCC TCAATGGCAG TCAGATTCTG 1020

CATAAGATTG ACAAGGAGGG GGAGCGCCTG CCCCGGCCTG AGGACTGCCC CCAGGACATC 1080

TATAATGTCA TGGTCCAGTG CTGGGCTCAT AAGCCGGAAG ACAGACCCAC CTTTGTGGCC 1140

CTGCGGGACT TCCTGCTGGA GGCCCAGCCC ACTGATATGC GGGCCCTTCA GGACTTTGAG 1200

GAACCTGACA AGCTACACAT CCAGATGAAT GATGTCATCA CTGTCATTGA GGGAAGGGCT 1260

GAAAACTACT GGTGGCGTGG ACAGAACACA CGGACGCTGT GTGTAGGACC CTTTCCTCGC 1320

AATGTGGTGA CCTCCGTGGC TGGTCTGTCA GCCCAGGACA TTAGCCAGCC CCTGCAGAAT 1380

AGCTTCATCC ACACAGGGCA TGGCGACAGC GACCCTCGCC ACTGTTGGGG CTTCCCTGAC 1440

AAGATTGACG AACTGTATCT GGGAAACCCC ATGGATCCTC CTGACCTGTT GAGTGTGGAA 1500

CTGAGCACCT CCCGACCCAC CCAGCACCTA GGAAGAGTGA AAAGGGAGCC TCCACCTCGC 1560

CCACCTCAGC CTGCCATCTT CACTCAGAAA CCAACCTATG ATCCTGTGAG TGAGGACCAA 1620

GACCTACTGT CTGGTGACTT CAAGAGGCTG GGCCTGCGGA AGCCAGGTCT GCCCCGAGGG 1680

CTGTGGCTAT CAAAGCCCTC AGCCCGGGTG CCCGGCACCA AGGCAGGCCG CAGCAGTGGG 1740

GGCGAGGTCA CGCTCATTGA CTTTGGTGAG GAACCTGTGA TTCCAGCCTC TCGGCCCTGT 1800

GCACCCTCTC TGGCACAGCT GGCCATGGAT GCCTGCTCTT TGCTGGACAA GACCCCTCCA 1860

CAGAGCCCTA CACGGGCACT ACCACGACCC CTGCATCCCA CGCCTGTGGT GGATTGGGAT 1920

GCACGCCCGC TTCCTCCTCC CCCTACCTAC GATGATGTGG CCCAAGACGA AGATGACTTT 1980

GAGGTCTGCT CCATCAACAG CACCCTGGTG GGTGCAGGGC TTCCTACTGG GCCCAGGCAG 2040

GGAGAGACCA ATTACGGCTT TGTGCCAGAG CAAGCACGGC TCCCTGCTGC CCTGGAGGAC 2100

AACCTGTTCC TCCCACCCCA GGGTGGGGGC AAGCCTCCCA GCTTGGCCCA GACCTCGGAG 2160

ATCTTCCAGG CACTGCAGCA GGAGTGTATG CGGCAGCTCC AAGTTCCGAC TGGCTCACTG 2220

GCCCCCTCAC CCAGCCCAGG GGCTGATGAT AAGCCCCAGG TGCCTCCCCG GGTACCCATC 2280

CCCCCTCGGC CCACACGCCC ACGTGTTGAG CTGTCTCCAG CCCCCTCAGG TGAGGAGGAG 2340

ATAGGTCGGT GGCCTGGACC TGCCTCTCCT CCCCGCATAC CTCCCCGGGA ACCTCTGTCC 2400

CCTCAAGGCT CTAGGACCCC CAGCCCCCTG GTACCACCTG GCGGTTCCCC CCTGCCACCC 2460

CGGCTCTCAA GCTCACCTGG GAAGACCATG CCCACTACCC AGAGCTTCGC TTCAGACCCC 2520

AAGTATGCTA CACCCCAGGT GATCCAGGCT CCTGGCCCAC GCACAGGTCC CTGCATCTTG 2580

CCCATTGTCC GGGATGGCAA GAAGGTCAGC AACACCCATT ATTACCTGTT GCCTGAGCGC 2640

CCGCCCTACT TGGAGCGCTA CCAGCGTTAC CTGCGTGAGG CCCAGAGCCC TGAAGAGCCG 2700

GCCCCTCTGC CTGTGCCCCT GCTGCTGCCC CCACCCAGCA CCCCAGCCCC TGCTGCCCCC 2760

ACTGCCACTG TTCGACCAAT GCCCCAGGCT GCTCCAGACC CCAAGGCCAA CTTCTCCACC 2820

AACAACAGCA ATCTAGGTAC CCGGCCACCA TCCCTGAGGG CCACTGCTCG GCTGCCACAG 2880

AGGGGCTGCC CTGGGGATGG GCCAGAGGCT GGCCGGCCAT CTGACAAGAT CCAGATGCTG 2940

CAGGCCATGG TGCATGGGGT GACCACAGAG GAGTGCCAGA CGGCCCTGCA GAGCCACAGC 3000

TGGAGTGTGC AGAGGGCTGC CCAGTATCTG AAGGTGGAGC AGCTCTTTGG GCTGGGTCTG 3060

TGGCCACGGT TGGAGTGCCA CAAAGTGCTA GAGATGTTCG ACTGGAACCT AGAGCAAGCT 3120

GGCTGTCACC TTCTGGGCTC CTGTGGCCCT GCCCACCACA AGTGA 3165

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60

         +lleklG+Gsfgvv+rgeW+ap+gk+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h

Q: 127   RLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  186

         789****************************************99***************

S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120

         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle

Q: 187   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  244

         ***********************************9..9*********************

S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180

         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t

Q: 245   SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  304

         ************************************************************

S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240

         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++

Q: 305   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVM  364

         ************************************************************

S: 241   lkcWakkpadrpkfsalkekl  261

         ++cWa+kp+drp+f+al+++l

Q: 365   VQCWAHKPEDRPTFVALRDFL  385

         ******************986

Domain Sequence
(FASTA)

RLLEKLGDGS FGVVRRGEWD APAGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60

RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120

RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180

FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PQDIYNVMVQ 240

CWAHKPEDRP TFVALRDFL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR000449	; UBA/transl_elong_EF1B_N.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.
PF00627	; UBA; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013