EPS-ICT-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ICT-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	288.6	5.2E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSSTOP00000004339

UniProt Accession

I3M4Y5;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000004840	ENSSTOP00000004339	ENSSTOT00000004834

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSAVAPSVE NVKNGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PTHVYFINCG DSRAVLYRNG EVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 300

VSEEAVKKDS ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

NIIEAVYSRL NPHRESDGAS DEAEESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL 420

AKVEGEESPA EPAAAAPSSN SDAGNPVTMQ ESHTESESGL AELDSCNEDA GTKMSGGKI 479

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAAAAACATA ATGCTCATGG TGCTGGGAAT 60

GGTTTACGTT ATGGCTTGAG CAGCATGCAA GGATGGAGAG TGGAAATGGA AGATGCACAC 120

ACAGCTGTCG TAGGTATTCC TCATGGCTTG GAAGACTGGT CATTTTTTGC AGTTTATGAT 180

GGTCATGCTG GATCCCGAGT GGCAAATTAC TGTTCAACAC ATTTATTAGA ACACATCACT 240

ACTAATGAAG ACTTCAGGGC AGCTGGCAAA TCAGGATCAG CTGTTGCACC TTCAGTGGAA 300

AATGTCAAAA ATGGTATCAG AACTGGCTTT TTGAAAATAG ATGAATATAT GCGTAATTTT 360

TCAGACCTCA GAAACGGGAT GGACAGGAGC GGTTCAACTG CAGTGGGAGT TATGATCTCA 420

CCTACACATG TCTACTTTAT CAACTGTGGT GATTCACGTG CTGTTCTGTA TAGGAATGGA 480

GAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGTAATC CAAGGGAAAA GGAGCGAATC 540

CAAAATGCAG GAGGCAGCGT GATGATACAG CGTGTTAACG GTTCATTAGC AGTGTCTCGT 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAAG GCCCTACAGA ACAACTTGTT 660

TCTCCAGAGC CCGAGGTTTA TGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGT AATGAGGAGC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TGTCTGATGA CCTGGAAAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTTTTAGTTT GCTTTTCAAA TGCCCCCAAG 900

GTCTCAGAGG AAGCAGTGAA AAAAGATTCA GAGTTGGATA AGCACTTGGA ATCAAGGGTT 960

GAAGAAATTA TGGAAAAGTC TGGTGAGGAA GGAATGCCTG ATCTTGCCCA TGTCATGCGC 1020

ATTTTGTCTG CCGAAAATAT CCCAAATTTA CCTCCTGGAG GAGGTCTTGC TGGCAAGCGC 1080

AATATTATTG AAGCTGTTTA TAGTAGACTG AATCCACATA GAGAAAGTGA TGGGGCCTCC 1140

GATGAAGCAG AGGAAAGTGG ATCACAGGGA AAATTGGTGG AAGCTCTCAG GCAAATGAGA 1200

ATTAATCATA GGGGAAACTA CCGACAACTT CTGGAGGAGA TGCTGACTAG TTACAGGCTA 1260

GCTAAAGTAG AGGGAGAAGA AAGCCCTGCT GAACCAGCTG CTGCAGCTCC TTCTTCGAAC 1320

AGTGATGCTG GAAACCCAGT GACAATGCAG GAAAGCCATA CTGAATCAGA AAGTGGTCTT 1380

GCTGAATTAG ACAGCTGTAA TGAAGATGCA GGGACAAAGA TGAGTGGTGG AAAAATATGA 1440

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + +++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TTNEDfraagksgsAVAPSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99********9999*******************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPTHVYFINCGDSRAVLYRNGEVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITTN 60

EDFRAAGKSG SAVAPSVENV KNGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPT 120

HVYFINCGDS RAVLYRNGEV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013