EKS-ICT-00350
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00350
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src435.94.2E-131260509250
StatusUnreviewed
Ensembl ProteinENSSTOP00000004441
UniProt AccessionI3M562;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000004951ENSSTOP00000004441ENSSTOT00000004951
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length524
Protein Sequence
(FASTA)
GVSSCPSHST PQPAGTGPAC RMGCVKSKFL RNRGKASKSE SSTNLQSPGY MPDPTTPIKL 60
GPNYNGNPPG FVEAGSEDTV VVALYDYEAI HREDLSFQKG DQMVVLEEAG EWWRARSLAT 120
RKEGYIPSNY VARVNSLETE EWFFKGISRK DAERHLLAPG NVLGSFMIRD SETTKGSYSL 180
SVRDYEPHQG DTVKHYKIRT LDNGGFYISP RSTFSNLQDL VAHYKKGKDG LCQKLSVPCV 240
SPKPQKPWEK DAWEIPRESL ELEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF 300
LAEANLMKTL QHDKLVKLHA VVTQEPIFIV TEFMAKGSLL DFLKSGEGSK QPLPKLIDFS 360
AQIAEGMAFI EQRNYIHRDL RAANILVSAS LVCKIADFGL ARIIEDNEYT AREGAKFPIK 420
WTAPEAINFG SFTIKSDVWS FGILLMEIVT YGRIPYPGMS NPEVIRALEH GYRMPRPEHC 480
PEELYNIMTR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP 524
Nucleotide Sequence
(FASTA)
GGTGTGTCTT CCTGTCCTTC CCACTCAACT CCCCAGCCCG CTGGTACTGG ACCAGCCTGC 60
AGGATGGGGT GCGTGAAGTC CAAGTTCCTC CGGAATAGAG GCAAGGCCTC CAAGTCTGAG 120
TCCAGCACCA ACCTGCAGAG CCCTGGGTAC ATGCCAGATC CCACGACCCC GATCAAGTTG 180
GGGCCTAACT ACAATGGCAA CCCCCCAGGG TTTGTGGAGG CAGGCTCTGA GGACACTGTT 240
GTGGTCGCCC TGTACGATTA CGAGGCCATC CACCGTGAAG ACCTCAGCTT CCAGAAGGGG 300
GACCAGATGG TGGTCCTGGA GGAGGCTGGG GAGTGGTGGA GGGCGCGATC TCTGGCCACC 360
AGGAAAGAGG GCTACATCCC AAGCAACTAT GTGGCCCGCG TGAATTCCCT GGAGACGGAG 420
GAGTGGTTCT TCAAGGGCAT CAGCCGGAAG GACGCAGAGC GCCACCTCCT GGCTCCCGGC 480
AACGTGCTGG GCTCCTTCAT GATCCGGGAC AGCGAGACCA CAAAAGGGAG CTACTCTCTG 540
TCGGTGCGAG ACTACGAGCC CCACCAAGGA GACACGGTGA AGCACTATAA GATCCGGACC 600
CTGGACAACG GGGGCTTCTA CATTTCCCCG AGGAGCACCT TCAGCAACCT ACAGGATCTG 660
GTGGCCCACT ATAAGAAGGG GAAGGACGGG CTCTGCCAGA AGCTGTCAGT GCCCTGTGTG 720
TCCCCCAAGC CCCAGAAGCC GTGGGAGAAA GACGCCTGGG AGATCCCTCG GGAGTCCCTG 780
GAGCTGGAGA AGAAGCTGGG CGCTGGGCAG TTTGGGGAAG TCTGGATGGC CACCTACAAC 840
AAGCACACCA AGGTGGCGGT GAAGACGATG AAGCCGGGGA GTATGTCGGT GGAGGCCTTC 900
CTGGCCGAGG CCAACCTGAT GAAGACGCTG CAGCATGACA AGCTGGTGAA GCTGCACGCG 960
GTGGTCACCC AGGAGCCCAT CTTCATCGTC ACAGAGTTCA TGGCCAAAGG AAGCCTGCTG 1020
GACTTTTTGA AAAGTGGAGA AGGCAGCAAG CAGCCCTTGC CAAAACTCAT CGACTTCTCA 1080
GCCCAGATTG CAGAAGGCAT GGCCTTCATC GAGCAGAGAA ACTATATCCA TCGGGACCTC 1140
CGAGCCGCCA ACATCCTGGT CTCTGCATCC CTGGTGTGTA AGATTGCTGA CTTTGGCCTG 1200
GCACGGATCA TCGAGGACAA CGAGTACACG GCTCGGGAAG GGGCCAAGTT CCCCATCAAG 1260
TGGACAGCTC CTGAGGCCAT CAACTTCGGC TCCTTCACCA TCAAGTCGGA CGTCTGGTCC 1320
TTTGGAATCC TACTGATGGA AATTGTCACC TATGGCCGGA TCCCTTACCC AGGAATGTCA 1380
AACCCAGAGG TGATCAGGGC GCTGGAGCAC GGGTACCGGA TGCCTCGACC CGAGCACTGC 1440
CCCGAGGAGC TCTACAACAT CATGACCCGC TGCTGGAAAA ACCGCCCGGA AGAGCGGCCC 1500
ACCTTTGAAT ATATCCAGAG TGTGCTGGAT GATTTCTACA CGGCCACCGA GAGCCAGTAC 1560
CAACAACAGC CTTGA 1575
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 260   LELEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  319
         5799********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePi+ivte+makGslldflk+ eg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 320   AVVTQ-EPIFIVTEFMAKGSLLDFLKSGEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  378
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 379   DLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  438
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGm+n ev++++e+gyr+prpe+cpeely+++++cwk++pee
Q: 439   WSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPEHCPEELYNIMTRCWKNRPEE  498
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 499   RPTFEYIQSVL  509
         *******9976
Domain Sequence
(FASTA)
LELEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60
AVVTQEPIFI VTEFMAKGSL LDFLKSGEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARIIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM SNPEVIRALE HGYRMPRPEH CPEELYNIMT RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
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EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013