EKS-ICT-00412

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00412

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	468.1	5.1E-141	82	332	251

Status

Unreviewed

Ensembl Protein

ENSSTOP00000004828

UniProt Accession

I3M600;

Protein Name

Protein Synonyms/Alias

Gene Name

AURKB

Gene Synonyms/Alias

AURKB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000005405	ENSSTOP00000004828	ENSSTOT00000005396

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

345

Protein Sequence
(FASTA)

MAQKENAYPW PYGRQTSQSG LNTLPQRVLR KEPATPSALV LMSRPNGLPT AAHGQKVGEN 60

SIGARNSRGR KWGKQPLTIN DFEIGRPLGK GKFGNVYLAR EKKSHFIVAL KVLFKSQIEK 120

EGVEHQLRRE IEIQAHLQHP NILRLYNYFY DRRRIYLILE YAPRGELYKE LQKCRTFDEQ 180

RTATIMEELA DALIYCHGKK VIHRDIKPEN LLLGLQGELK IADFGWSVHA PSLRRKTMCG 240

TLDYLPPEMI EGRTHNEKVD LWCIGILCYE LLVGNPPFES ASHNETYRRI VKVDLKFPPS 300

MPAGAQDLIC KLLKHNPSER LPLAQVSAHP WVRAHSRRVL PPSAP 345

Nucleotide Sequence
(FASTA)

ATGGCCCAGA AGGAGAATGC CTACCCCTGG CCTTACGGCC GGCAGACGTC TCAATCGGGC 60

CTGAACACCC TACCCCAGAG GGTCCTCCGG AAGGAGCCTG CCACCCCATC TGCACTTGTC 120

CTCATGAGTC GCCCCAACGG CCTGCCCACA GCTGCCCATG GCCAGAAGGT GGGAGAAAAT 180

AGCATTGGCG CACGCAACTC CAGAGGCAGG AAATGGGGGA AACAGCCCCT CACAATCAAC 240

GACTTTGAGA TTGGGCGTCC TCTGGGCAAA GGCAAATTTG GAAATGTGTA CTTGGCTCGA 300

GAGAAGAAAA GTCATTTCAT TGTGGCACTC AAGGTCCTCT TCAAGTCCCA GATCGAGAAG 360

GAAGGTGTGG AACACCAGCT GCGCAGGGAG ATCGAGATCC AGGCCCATCT GCAGCATCCC 420

AACATCTTGC GGCTCTACAA CTATTTTTAT GATCGGAGGA GGATCTACTT GATTCTGGAG 480

TATGCCCCCC GGGGAGAGCT CTACAAGGAG CTACAGAAGT GCCGCACTTT TGATGAGCAA 540

CGAACAGCCA CGATCATGGA GGAGTTGGCG GATGCTCTGA TATACTGCCA TGGGAAAAAG 600

GTGATTCACA GAGATATAAA GCCAGAAAAT CTGCTTTTAG GGCTCCAAGG TGAGCTGAAG 660

ATTGCAGACT TTGGCTGGTC GGTGCACGCT CCCTCTCTGA GGAGGAAGAC AATGTGTGGT 720

ACCCTAGACT ACCTGCCCCC AGAGATGATT GAGGGGCGCA CACACAATGA GAAGGTAGAT 780

CTCTGGTGCA TCGGAATACT CTGCTATGAG CTGCTGGTGG GGAACCCACC CTTTGAGAGT 840

GCCTCACACA ATGAGACCTA TCGGAGGATC GTCAAGGTGG ACCTGAAGTT CCCTCCTTCT 900

ATGCCCGCAG GGGCCCAGGA CCTCATCTGC AAGCTGCTCA AACATAACCC CTCTGAAAGG 960

CTGCCCCTGG CCCAGGTCTC TGCTCACCCT TGGGTCCGGG CCCATTCGCG GAGGGTGCTG 1020

CCTCCCTCTG CCCCT 1035

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         feiGr+lGkGkfGnvylarekks+fivalkvlfk+q+ekegve+qlrreieiq+hl+hpn

Q: 82    FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLQHPN  141

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrly+yf+d++r+ylileyaprGelykelqk +++deqr+a+++eeladal y+h kkv

Q: 142   ILRLYNYFYDRRRIYLILEYAPRGELYKELQKCRTFDEQRTATIMEELADALIYCHGKKV  201

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllg++gelk+adfGwsvhaps +rkt+cGtldylppem+egr+++ekvdl

Q: 202   IHRDIKPENLLLGLQGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRTHNEKVDL  261

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl  240

         w++G+lcyellvG+ppfes+s++ety+ri+kvdlk+p s+++ga+dli kllk++p+erl

Q: 262   WCIGILCYELLVGNPPFESASHNETYRRIVKVDLKFPPSMPAGAQDLICKLLKHNPSERL  321

         ************************************************************

S: 241   tladvlahpwi  251

         +la+v+ahpw+

Q: 322   PLAQVSAHPWV  332

         **********8

Domain Sequence
(FASTA)

FEIGRPLGKG KFGNVYLARE KKSHFIVALK VLFKSQIEKE GVEHQLRREI EIQAHLQHPN 60

ILRLYNYFYD RRRIYLILEY APRGELYKEL QKCRTFDEQR TATIMEELAD ALIYCHGKKV 120

IHRDIKPENL LLGLQGELKI ADFGWSVHAP SLRRKTMCGT LDYLPPEMIE GRTHNEKVDL 180

WCIGILCYEL LVGNPPFESA SHNETYRRIV KVDLKFPPSM PAGAQDLICK LLKHNPSERL 240

PLAQVSAHPW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013