EPS-ICT-00117

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ICT-00117

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	551.0	6.7E-166	122	455	334

Status

Unreviewed

Ensembl Protein

ENSSTOP00000019950

UniProt Accession

I3N6F4;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000005660	ENSSTOP00000019950	ENSSTOT00000027233
ENSSTOG00000005660	ENSSTOP00000005072	ENSSTOT00000005668

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

654

Protein Sequence
(FASTA)

VNCSCSGTVK RRKSTMLKAT LVIQNWYRGY RARLKARQHY ALAIFQSIEY ADEHGQMQLS 60

NFFTFMLENC SRARKEDPEL VSRLFESTFQ DIKDRQEYVG LIDVPDSYEG PRLEFPLTFT 120

DINHLLEAFK QQQILHAHYV LEVLFETRKL LKHMPNFTHV KTSPSKEITV CGDLHGKLDD 180

LFLIFYKNGL PSGNNPYVFN GDFVDRGSNS VEVLMILLVS FLVYPNDLHL NRGNHEDFMM 240

NMRYGFTREI LFKYKLHGKK ILQILEEVYT LLPIGTIIDN EILVIHGGIS ESTDLNLLHR 300

LERSKMRSVL MPPVSINRGH ATDSKKSKGD ITVTSSGKVK SNGFPSQQLS KHEWEQVVDI 360

LWSDPRGRKG CYPNTSRGGG CYFGPDVTSK ILNKYQLKML IRSHECKHDG YEICHDGKVI 420

TIFSASNYYE EGSNRGAYIR LSYGMNPRFF QYRVTSSTCM SPLHQRVHAM ETSAIRILKE 480

RIISRKTDLM HAFQLRDHSR SGKISIAQWA FSMESILGLN LPWRSLSLRL VNIDTNGNVD 540

YMSSFQDVHI EKPVKEVQST LIETLYRYRS DLQIIFNVID SDHSGLISME EFRAMWKLFR 600

THYSVDIDDS QVDELANIMD LNKDGSIDFN EFLKAFHVVH KYEKFHKPVI LNCG 654

Nucleotide Sequence
(FASTA)

GTAAACTGCT CATGCTCAGG TACAGTCAAA AGGAGGAAAA GTACAATGTT AAAAGCCACC 60

TTGGTCATCC AGAACTGGTA CCGAGGTTAC AGAGCTCGGC TGAAGGCCAG ACAACACTAT 120

GCCCTTGCCA TCTTCCAGTC CATCGAATAT GCTGATGAAC ATGGTCAAAT GCAGTTATCC 180

AATTTCTTTA CCTTCATGTT GGAAAACTGT TCACGAGCAC GTAAGGAAGA TCCAGAACTT 240

GTAAGTCGGC TTTTTGAAAG CACCTTCCAG GATATCAAGG ATAGACAGGA GTATGTAGGG 300

TTGATAGATG TACCAGACTC TTATGAAGGC CCTCGCCTGG AATTTCCTCT CACTTTTACT 360

GACATCAATC ACCTCCTTGA GGCCTTTAAG CAACAACAGA TACTTCATGC TCATTATGTC 420

TTAGAGGTGT TATTTGAAAC CAGGAAACTC CTGAAGCATA TGCCGAATTT CACTCATGTA 480

AAAACTTCTC CCTCCAAAGA GATAACAGTC TGTGGTGATT TACATGGGAA ACTGGATGAC 540

CTTTTTTTGA TCTTCTATAA GAATGGTCTC CCATCGGGGA ACAACCCATA TGTTTTTAAT 600

GGTGATTTTG TAGATCGAGG CAGTAACTCC GTAGAGGTCC TCATGATCCT GCTTGTGAGT 660

TTTCTTGTCT ACCCCAATGA CCTGCACTTG AACAGAGGGA ATCATGAGGA TTTTATGATG 720

AATATGAGGT ATGGCTTCAC AAGAGAAATC TTGTTTAAAT ACAAGCTGCA TGGAAAAAAA 780

ATCTTGCAAA TCTTGGAAGA AGTCTATACC TTGCTCCCAA TTGGTACAAT TATTGACAAT 840

GAAATTCTGG TGATACATGG CGGGATATCA GAGTCCACAG ATTTGAATTT ACTCCACCGC 900

CTAGAGAGAA GCAAAATGAG ATCTGTGCTG ATGCCACCAG TGTCAATAAA TAGAGGCCAT 960

GCCACCGACT CTAAGAAAAG TAAAGGGGAC ATTACTGTTA CTTCATCAGG AAAAGTCAAA 1020

TCAAATGGTT TCCCTTCTCA ACAGTTATCA AAGCATGAAT GGGAGCAGGT TGTTGACATT 1080

CTGTGGAGTG ACCCCAGAGG AAGAAAAGGC TGTTATCCAA ACACAAGTCG AGGAGGAGGC 1140

TGCTATTTTG GACCAGACGT TACCTCTAAG ATTCTCAATA AATACCAGTT GAAGATGCTC 1200

ATTAGGTCTC ATGAATGTAA GCATGATGGG TATGAAATCT GCCATGATGG GAAGGTTATT 1260

ACCATATTTT CTGCTTCTAA TTATTACGAA GAAGGCAGCA ATCGTGGAGC TTACATCAGA 1320

CTGAGTTATG GTATGAACCC ACGATTTTTC CAGTACCGAG TAACTAGTTC AACATGCATG 1380

AGCCCTCTTC ACCAAAGGGT ACATGCTATG GAAACTAGTG CCATCAGGAT ATTAAAAGAG 1440

AGAATAATTT CACGAAAAAC TGACCTCATG CATGCTTTCC AACTTCGAGA CCACAGTCGA 1500

TCAGGAAAAA TTTCAATAGC CCAATGGGCT TTTTCTATGG AGAGCATTTT GGGGCTGAAC 1560

TTACCATGGA GATCTCTGAG TTTGCGTCTG GTAAACATAG ACACAAATGG AAATGTTGAC 1620

TACATGTCCA GCTTCCAGGA TGTCCACATT GAAAAACCTG TGAAAGAGGT CCAATCTACT 1680

CTAATTGAAA CTCTGTACAG ATACCGATCT GATCTGCAAA TCATATTTAA TGTCATTGAC 1740

TCTGATCACT CAGGCCTGAT CTCCATGGAA GAATTTCGGG CCATGTGGAA ACTTTTCAGG 1800

ACTCACTACA GCGTTGATAT TGATGATTCC CAAGTTGATG AACTTGCCAA TATAATGGAC 1860

TTAAACAAAG ATGGAAGCAT TGACTTTAAT GAGTTTTTAA AGGCTTTCCA TGTAGTGCAT 1920

AAATATGAGA AATTCCATAA ACCAGTGATC CTTAATTGTG GG 1962

Domain Profile

S: 1     idlllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddl  60

         i+ lle+fk+++ilha+yvlevlfe++k lk +pn++hv+t++ske+tv+GdlhGklddl

Q: 122   INHLLEAFKQQQILHAHYVLEVLFETRKLLKHMPNFTHVKTSPSKEITVCGDLHGKLDDL  181

         5779********************************************************

S: 61    llvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmn  120

         +l+++knGlPs +npyvfnGdfvdrG +++evl++ll++flv+Pn+++lnrGnhed++mn

Q: 182   FLIFYKNGLPSGNNPYVFNGDFVDRGSNSVEVLMILLVSFLVYPNDLHLNRGNHEDFMMN  241

         ************************************************************

S: 121   aryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksv  180

         +ryGf++e+l kyk +gk+il+ileevy+ lP+g+i+d+++lv+hGG+sest+l+ll+++

Q: 242   MRYGFTREILFKYKLHGKKILQILEEVYTLLPIGTIIDNEILVIHGGISESTDLNLLHRL  301

         ************************************************************

S: 181   erkkrksvllpPeessrd................lgrldtdgepreslteteweqiidil  224

         er k++svl+pP   +r                  g+++ +g p+++l ++eweq++dil

Q: 302   ERSKMRSVLMPPVSINRGhatdskkskgditvtsSGKVKSNGFPSQQLSKHEWEQVVDIL  361

         *************9999899****************************************

S: 225   wsdPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvt  284

         wsdPr+++G++Pnt rG+G+yfGPdvt+++l+ky+lk++irsheck +gyei+hdgkv+t

Q: 362   WSDPRGRKGCYPNTSRGGGCYFGPDVTSKILNKYQLKMLIRSHECKHDGYEICHDGKVIT  421

         ************************************************************

S: 285   ifsasnyyeegsnkgayiklnsqltprfvqyiva  318

         ifsasnyyeegsn+gayi+l+ ++ prf+qy v+

Q: 422   IFSASNYYEEGSNRGAYIRLSYGMNPRFFQYRVT  455

         *******************************997

Domain Sequence
(FASTA)

INHLLEAFKQ QQILHAHYVL EVLFETRKLL KHMPNFTHVK TSPSKEITVC GDLHGKLDDL 60

FLIFYKNGLP SGNNPYVFNG DFVDRGSNSV EVLMILLVSF LVYPNDLHLN RGNHEDFMMN 120

MRYGFTREIL FKYKLHGKKI LQILEEVYTL LPIGTIIDNE ILVIHGGISE STDLNLLHRL 180

ERSKMRSVLM PPVSINRGHA TDSKKSKGDI TVTSSGKVKS NGFPSQQLSK HEWEQVVDIL 240

WSDPRGRKGC YPNTSRGGGC YFGPDVTSKI LNKYQLKMLI RSHECKHDGY EICHDGKVIT 300

IFSASNYYEE GSNRGAYIRL SYGMNPRFFQ YRVT 334

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013