EKS-ICT-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	374.7	4.0E-112	11	347	337

Status

Unreviewed

Ensembl Protein

ENSSTOP00000005137

UniProt Accession

I3M6L8;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK4

Gene Synonyms/Alias

HIPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000005746	ENSSTOP00000005137	ENSSTOT00000005744

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

616

Protein Sequence
(FASTA)

MATIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRSR IIKNELKLLR 60

CMRGLDPDEA HIIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV 120

LRALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF 180

YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH 240

ASRKAHHFFK RNPHPDATNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAA 300

SRLTFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRSAHETTR 360

YYQLSLRGCR LSLQVEGKPP PPVMATTEDG PPYYRLAEEE EAVGMGNVAG SGPFFREEKA 420

PAVQRAIDQL DDLSLQEAGR GLWGETRADV VSDMLAPLKA ATTGRRVPDS GPEPILAFYG 480

SRLAGRHKAR KPPAGSKSDS NFSNLIRLSQ ASPEDDGPCR GSGWEEGECQ GASAEPPAIP 540

QREGDGPNIK DMTMDAERSG PELFDPSSCP GEWLSEPDWT LEGVRGPRAQ GLPPRHPHPH 600

GPPRATSFLQ HVGGHH 616

Nucleotide Sequence
(FASTA)

ATGGCCACCA TCCAGTCGGA GACCGACTGT TACGACATCA TTGAGGTGCT GGGCAAGGGC 60

ACCTTTGGGG AAGTGGCCAA GGGATGGCGG CGAAGCACGG GTGAGATGGT GGCCATCAAG 120

ATCCTCAAGA ACGACGCCTA CCGCAGCCGC ATCATCAAGA ACGAGCTGAA GCTGCTCCGC 180

TGTATGCGGG GCCTGGACCC CGACGAGGCC CACATCATCC GCTTCCTCGA GTTCTTCCAC 240

GACGCCCTCA AGTTCTACCT GGTCTTCGAG CTGCTGGAGC AAAACCTCTT TGAGTTCCAG 300

AAGGAGAACA ACTTCGCACC CCTCCCGGCC CGTCACATCC GGACGGTCAC CCTGCAGGTG 360

CTCAGAGCCC TGGCCCGGCT CAAGGAGCTG GCCATCATCC ACGCCGACCT CAAACCCGAG 420

AACATCATGC TGGTGGATCA GACCCGCTGT CCCTTCAGGG TCAAGGTGAT TGACTTTGGC 480

TCAGCCAGTA TTTTCAGTGA GGTGCGCTAT GTGAAAGAGC CGTACATCCA GTCTCGCTTC 540

TACCGGGCCC CTGAGATTCT GCTGGGGCTC CCCTTCTGTG AGAAGGTGGA TGTGTGGTCG 600

CTGGGCTGTG TCATGGCTGA ACTGCACCTG GGCTGGCCCC TCTACCCCGG CAACAACGAG 660

TATGACCAGG TGCGCTACAT CTGTGAGACC CAGGGCCTGC CCAAGCCACA CCTGCTGCAC 720

GCCTCCCGCA AGGCCCACCA CTTCTTCAAG CGTAACCCCC ACCCTGATGC CACCAATCCC 780

TGGCAGCTCA AGTCCTCAGC TGACTACCTG GCTGAGACCA AGGTGCGTCC CCTGGAGCGT 840

CGCAAGTACA TGCTCAAGTC CTTGGACCAG ATCGAGACGG TGAATGGTGG CGGGGCTGCC 900

AGCCGGCTGA CCTTCCCGGA CCGGGAGGCA CTGGCCGAGC ACGCGGACCT CAAGAGCATG 960

GTGGAGCTGA TCAAGCGCAT GCTGACGTGG GAGTCCCACG AGCGCATCAG CCCCAGCGCG 1020

GCCCTGCGCC ACCCCTTCGT GTCCATGCAG CAGCTGCGCA GTGCACACGA GACCACGCGG 1080

TACTACCAGC TGTCCCTGCG CGGCTGCCGC CTCTCGCTGC AGGTGGAGGG CAAGCCACCC 1140

CCGCCTGTCA TGGCCACCAC AGAAGATGGG CCCCCTTACT ACCGGCTGGC CGAGGAGGAG 1200

GAGGCCGTGG GCATGGGCAA CGTGGCGGGC AGCGGGCCCT TCTTCCGGGA GGAGAAGGCT 1260

CCGGCCGTGC AGAGAGCCAT CGACCAGCTG GACGACCTGA GCCTGCAGGA GGCCGGCCGC 1320

GGGCTCTGGG GGGAGACCCG GGCCGATGTG GTCTCCGACA TGCTGGCCCC TCTCAAGGCG 1380

GCCACCACGG GCCGCCGGGT CCCCGACTCT GGCCCAGAGC CCATCCTGGC CTTCTATGGC 1440

AGCCGCCTAG CAGGACGCCA CAAGGCCCGC AAGCCGCCCG CGGGCTCCAA GTCCGACTCC 1500

AACTTCAGCA ACCTCATCCG GCTGAGCCAG GCCTCGCCCG AGGACGATGG GCCCTGCCGG 1560

GGGAGTGGCT GGGAGGAAGG CGAGTGCCAA GGGGCCTCCG CGGAGCCGCC TGCCATCCCA 1620

CAGCGGGAGG GAGATGGACC CAACATCAAG GACATGACCA TGGACGCTGA GAGGTCAGGC 1680

CCTGAGCTCT TCGACCCCAG CAGCTGTCCT GGAGAGTGGC TGAGTGAGCC CGACTGGACC 1740

CTGGAGGGAG TCAGGGGGCC ACGGGCTCAG GGGCTCCCAC CCCGCCACCC CCACCCACAT 1800

GGTCCGCCCC GGGCCACCAG CTTTCTGCAG CACGTTGGCG GGCACCACTG A 1851

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         y+++ev+gkG+fg+V+k+++++t e+vaiki+kn++   r +++E+++L++++  d++e+

Q: 11    YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKNELKLLRCMRGLDPDEA  70

         99*******************************************************988

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

          +++r+le+f+   +++lvfell+qnL+e+ k+n+f++l+ +++r+++ q+l+aL+ Lke

Q: 71    -HIIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKE  129

         .9**********************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqk..eiytyiqsrfYraPEiilg  176

         l+iiHaDlKPeNi+lv+++r++  vkviDFGs+s +s+   + ++yiqsrfYraPEi+lg

Q: 130   LAIIHADLKPENIMLVDQTRCPfrVKVIDFGSASIFSEVryVKEPYIQSRFYRAPEILLG  189

         *********************999**********99987447899***************

S: 177   lkydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff  236

         l+++e++D+WSlGcv+aEl++G+pL+pG+ne+dq+++i+e++glp+++ll++++ka++ff

Q: 190   LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHASRKAHHFF  249

         ************************************************************

S: 237   tkkeapkyilktk.............ksdrkkklvlnvkkaakkrkaplske.....lge  278

         +++ +p  +  ++                +++k++l+  +++++++  ++++      +e

Q: 250   KRNPHPDATNPWQlkssadylaetkvRPLERRKYMLKSLDQIETVNGGGAASrltfpDRE  309

         888888777666667779999988886667778888888888777655444311111578

S: 279   alkekedkl.fkdllkrmleldpakRitpkealkhpfv  315

         al+e++d + +++l+krml++++++Ri+p++al+hpfv

Q: 310   ALAEHADLKsMVELIKRMLTWESHERISPSAALRHPFV  347

         8888889888***************************7

Domain Sequence
(FASTA)

YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRSR IIKNELKLLR CMRGLDPDEA 60

HIIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV LRALARLKEL 120

AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF YRAPEILLGL 180

PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH ASRKAHHFFK 240

RNPHPDATNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAA SRLTFPDREA 300

LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFV 337

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013