EKS-ICT-00252

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00252

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	456.9	3.7E-137	193	521	329

Status

Unreviewed

Ensembl Protein

ENSSTOP00000005333

UniProt Accession

I3M711;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK2

Gene Synonyms/Alias

HIPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000005957	ENSSTOP00000005333	ENSSTOT00000005963

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1192

Protein Sequence
(FASTA)

GMASHVQVFS PHTLQSSAFC SVKKLKVEPS STWDMTGYGS HSKVYNQSKN IPPSQPATTT 60

VSTSLPIPNP SLPYEQTIIF PGSTGHIVVT SASSTSVTGQ VLGGPHNLMR RSTVSLLDTY 120

QKCGLKRKSE EIENTSSVQI IEEHPPMIQN NASGATVATA TTSTATSKNS GSNSEGDYQL 180

VQHEVLCSMT NTYEVLEFLG RGTFGQVVKC WKRGTNEIVA IKILKNHPSY ARQGQIEVSI 240

LARLSTESAD DYNFVRAYEC FQHKNHTCLV FEMLEQNLYD FLKQNKFSPL PLKYIRPVLQ 300

QVATALMKLK SLGLIHADLK PENIMLVDPS RQPYRVKVID FGSASHVSKA VCSTYLQSRY 360

YRAPEIILGL PFCEAIDMWS LGCVIAELFL GWPLYPGASE YDQIRYISQT QGLPAEYLLS 420

AGTKTTRFFN RDTDSPYPLW RLKTPDDHEA ETGIKSKEAR KYIFNCLDDM AQVNMTTELE 480

GSDMLVEKAD RREFIDLLKK MLTIDADKRI TPIETLNHPF VTMTHLLDFP HSTHVKSCFQ 540

NMEICKRRVN MYDTVNQSKT PFITHVAPST STNLTMTFNN QLTTVHNQAP TSTSATISLA 600

NPEVSILNYQ STLYQPSAAS MAAVAQRSMP LQTGTAQICA RPDPFQQALI VCPPGFQGLQ 660

ASPSKHAGYS VRMENAVPIV TQAPGAQPLQ IQPGLLAQQA WPSGTQQILL PSAWQQLTGV 720

ATHTSVQHAT VIPETMAGTQ QLADWRNTHA HGSHYNPIMQ QPALLTGHVT LPAAQPLNVG 780

VAHVMRQQPT STTSSRKSKQ HQSSVRNVST CEVSSSQAIS SPQRSKRVKE NTPPRCAMVH 840

SSPACSTSVT CGWGDMASST TRERQRQTIV IPDTPSPTVS VITISSDTDE EEEQKHAPTS 900

TVSKQRKNVI SCVTVHDSPY SDSSSNTSPY SVQQRAGHNN TNTFDSKGTL ENHCTGNPRT 960

IIVPPLKTQA SEVLVECDSL GPAVNTSHHS SSYKSKSSSN VTSTSGHSSG SSSGAIAYRQ 1020

QRPGPHFQQQ QPLNLSQAQQ HMAADRTGSH RRQQAYIAPT MAQAPYTFPH NSPSHGTVHP 1080

HLAAAAAAHL PTQPHLYTYT APAALGSTGT VAHLVASQGS ARHTVQHTAY PASIVHQVPV 1140

SMGPRVLPSP TIHPSQYPAQ FAHQTYISAS PASTVYTGYP LSPAKVNQYP YI 1192

Nucleotide Sequence
(FASTA)

GGTATGGCCT CACATGTGCA AGTTTTCTCC CCTCACACCC TTCAATCAAG TGCCTTCTGT 60

AGTGTGAAGA AACTGAAAGT GGAGCCGAGT TCCACCTGGG ACATGACTGG GTACGGCTCC 120

CACAGCAAAG TGTATAACCA GAGCAAGAAC ATCCCGCCTT CTCAGCCAGC CACCACGACC 180

GTCAGCACCT CCTTGCCGAT CCCAAACCCA AGCCTACCTT ACGAGCAGAC CATCATCTTC 240

CCAGGAAGCA CCGGGCACAT AGTCGTAACA TCAGCAAGTA GCACTTCTGT CACGGGGCAA 300

GTCCTCGGCG GACCACACAA CCTAATGCGT CGAAGCACTG TGAGCCTTCT TGACACCTAC 360

CAAAAATGTG GACTCAAGCG CAAGAGTGAG GAGATTGAGA ACACAAGCAG CGTGCAGATC 420

ATCGAAGAGC ATCCACCCAT GATTCAGAAC AATGCCAGCG GGGCCACTGT AGCCACTGCC 480

ACCACGTCCA CTGCCACCTC CAAAAACAGT GGCTCCAACA GTGAAGGAGA TTATCAGCTG 540

GTGCAGCATG AAGTGCTGTG CTCCATGACT AATACCTACG AGGTCTTAGA GTTCCTGGGC 600

CGGGGGACGT TTGGGCAAGT GGTCAAATGC TGGAAACGGG GCACCAATGA AATTGTGGCC 660

ATCAAGATTC TGAAGAACCA CCCGTCCTAT GCCCGGCAGG GTCAGATCGA AGTGAGCATC 720

CTGGCCCGGC TGAGCACGGA GAGCGCCGAT GACTACAACT TTGTGCGGGC CTACGAGTGC 780

TTCCAGCACA AGAACCACAC GTGCTTGGTC TTTGAGATGT TGGAGCAGAA CCTCTATGAC 840

TTTCTGAAGC AGAACAAGTT TAGCCCCTTG CCCCTCAAGT ACATTCGCCC GGTCCTCCAG 900

CAGGTGGCCA CAGCCCTGAT GAAACTCAAA AGCCTAGGTC TTATCCATGC TGACCTCAAG 960

CCAGAGAACA TCATGCTGGT GGATCCATCC CGGCAGCCAT ACAGAGTCAA GGTCATCGAC 1020

TTCGGTTCAG CCAGTCACGT GTCCAAGGCT GTGTGCTCCA CCTACCTGCA GTCCCGATAC 1080

TACAGGGCCC CTGAGATCAT CCTTGGTTTA CCGTTTTGCG AGGCGATTGA CATGTGGTCC 1140

CTGGGCTGTG TCATTGCAGA GCTGTTCCTA GGTTGGCCAT TGTATCCAGG AGCTTCTGAG 1200

TATGATCAGA TTCGGTATAT TTCACAAACA CAGGGTTTGC CAGCTGAATA TTTATTAAGC 1260

GCAGGGACAA AGACAACCAG GTTTTTCAAC CGTGACACAG ACTCGCCGTA TCCTCTGTGG 1320

AGACTGAAGA CACCAGATGA CCATGAAGCA GAGACGGGGA TTAAGTCAAA AGAAGCAAGA 1380

AAGTACATTT TCAACTGTTT AGATGACATG GCCCAGGTGA ACATGACGAC AGAGTTGGAA 1440

GGGAGTGACA TGTTGGTGGA GAAGGCAGAC CGGCGGGAGT TCATTGACCT GTTGAAGAAG 1500

ATGCTGACCA TAGATGCTGA TAAGAGAATC ACGCCAATTG AAACCCTGAA CCACCCCTTT 1560

GTCACCATGA CACACCTACT CGATTTTCCC CATAGCACAC ATGTCAAATC GTGTTTCCAA 1620

AACATGGAGA TTTGCAAACG TCGGGTGAAC ATGTATGACA CAGTGAACCA GAGCAAAACC 1680

CCTTTCATCA CGCATGTGGC CCCCAGCACC TCTACCAACC TGACCATGAC CTTCAACAAC 1740

CAGCTGACCA CTGTCCACAA CCAGGCTCCC ACCTCCACCA GTGCCACTAT TTCCTTAGCC 1800

AATCCCGAAG TCTCCATACT AAACTACCAA TCTACACTCT ACCAGCCCTC AGCGGCATCC 1860

ATGGCTGCAG TGGCCCAGCG GAGCATGCCC CTGCAGACGG GAACAGCCCA GATTTGTGCC 1920

CGGCCTGACC CCTTCCAGCA AGCTCTCATC GTGTGTCCTC CTGGCTTCCA AGGCTTGCAG 1980

GCTTCCCCCT CGAAGCACGC TGGCTACTCA GTGCGAATGG AAAATGCGGT GCCTATTGTC 2040

ACTCAAGCGC CAGGAGCTCA GCCTCTTCAG ATCCAACCAG GTCTGCTTGC CCAGCAGGCC 2100

TGGCCGAGTG GGACCCAACA GATCCTGCTT CCTTCAGCAT GGCAGCAGCT GACTGGAGTG 2160

GCCACCCACA CATCAGTGCA GCATGCGACT GTAATTCCCG AGACCATGGC AGGCACCCAG 2220

CAGTTGGCCG ACTGGAGGAA CACGCATGCG CACGGCAGCC ATTACAATCC CATCATGCAG 2280

CAGCCCGCGC TATTGACTGG TCATGTGACC CTCCCAGCCG CCCAGCCCTT AAATGTGGGT 2340

GTGGCCCACG TGATGCGGCA GCAGCCAACC AGCACCACCT CCTCTCGGAA GAGTAAGCAG 2400

CACCAGTCAT CTGTGAGAAA CGTCTCCACC TGTGAAGTGT CCTCCTCCCA GGCCATCAGC 2460

TCCCCTCAGC GATCCAAACG TGTCAAGGAG AACACACCTC CCCGCTGCGC CATGGTGCAC 2520

AGCAGCCCAG CCTGCAGTAC CTCCGTCACA TGTGGGTGGG GCGACATGGC CTCCAGCACC 2580

ACCAGAGAGC GGCAGCGACA AACGATTGTC ATCCCCGATA CCCCCAGCCC CACTGTCAGC 2640

GTCATCACCA TCAGCAGCGA CACAGATGAG GAGGAGGAAC AAAAACATGC CCCCACCAGC 2700

ACTGTCTCCA AGCAAAGAAA AAATGTCATC AGCTGCGTCA CAGTCCACGA CTCTCCCTAC 2760

TCGGACTCCT CCAGCAACAC CAGCCCCTAC TCTGTGCAGC AGCGTGCCGG GCACAATAAC 2820

ACCAACACCT TTGACAGCAA GGGGACTCTG GAGAATCATT GCACTGGCAA CCCCCGAACC 2880

ATCATCGTGC CCCCCTTGAA GACCCAGGCC AGTGAGGTGT TGGTGGAATG CGACAGCCTG 2940

GGGCCAGCAG TCAACACCAG TCACCACTCG TCCTCCTACA AGTCCAAGTC CTCCAGCAAT 3000

GTGACCTCTA CCAGCGGTCA TTCTTCAGGG AGCTCGTCGG GAGCCATCGC CTACCGGCAG 3060

CAGCGGCCAG GCCCCCATTT CCAGCAGCAG CAGCCCCTCA ATCTCAGTCA GGCCCAGCAG 3120

CACATGGCCG CAGACCGCAC CGGGAGCCAT CGACGGCAGC AGGCCTACAT CGCTCCCACC 3180

ATGGCTCAGG CTCCGTACAC CTTCCCACAC AACAGCCCCA GCCACGGCAC TGTCCACCCG 3240

CACCTGGCTG CCGCTGCCGC CGCCCACCTC CCCACCCAGC CTCACCTCTA CACCTACACA 3300

GCGCCTGCAG CCCTGGGCTC CACTGGCACC GTGGCCCACC TGGTGGCCTC CCAAGGCTCG 3360

GCTCGCCACA CCGTGCAGCA CACTGCCTAC CCGGCCAGCA TCGTCCACCA GGTCCCCGTG 3420

AGCATGGGCC CCCGGGTCCT GCCCTCGCCC ACCATCCACC CAAGTCAGTA TCCAGCCCAG 3480

TTTGCCCACC AGACCTACAT CAGCGCCTCG CCAGCCTCCA CCGTCTACAC TGGATACCCA 3540

CTGAGCCCTG CCAAGGTCAA CCAGTACCCT TACATATAA 3579

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 193   YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ESADD  251

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr++e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+

Q: 252   YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS  311

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv+++r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 312   LGLIHADLKPENIMLVDPSRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  371

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff

Q: 372   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  431

         **********************************************************88

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

          t++ +p ++lkt          ks++++k+++n+ +++++++++++ e +++l ek+d+

Q: 432   dTDSPYPLWRLKTPddheaetgiKSKEARKYIFNCLDDMAQVNMTTELEGSDMLVEKADR  491

         87889999999999********************************************99

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + f+dllk+ml++d++kRitp e+l+hpfv

Q: 492   ReFIDLLKKMLTIDADKRITPIETLNHPFV  521

         99***************************7

Domain Sequence
(FASTA)

YEVLEFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTESADDY 60

NFVRAYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPVLQQV ATALMKLKSL 120

GLIHADLKPE NIMLVDPSRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240

TDSPYPLWRL KTPDDHEAET GIKSKEARKY IFNCLDDMAQ VNMTTELEGS DMLVEKADRR 300

EFIDLLKKML TIDADKRITP IETLNHPFV 329

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013