EKS-ICT-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	416.1	5.2E-125	62	314	253

Status

Unreviewed

Ensembl Protein

ENSSTOP00000005707

UniProt Accession

I3M7T9;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK3

Gene Synonyms/Alias

PLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000006358	ENSSTOP00000005707	ENSSTOT00000006383

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

646

Protein Sequence
(FASTA)

MEPAAGFLSP RPFPRAAAPP APPARPGPPP SALPRSEQEM LAGPPAPDPG RLITDPSSGR 60

TYFKGRLLGK GGFARCYEAT DTETRSAYAV KVIPQSRVAK PHQREKILNE IELHRDLQHR 120

HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRG 180

ILHRDLKLGN FFITDNMELK VGDFGLAARL EPPEQRKKTI CGTPNYVAPE VLLRQGHGPE 240

ADVWSLGCVM YTLLCGTPPF ETADLKETYR CIKQVHYTLP ASLSLSARQL LAAILRASPR 300

DRPSIDQILR HDFFTKGYTP DRLPVSSCIT VPDLTPPNPA RSLFAKVTKS LFGRKKKNKN 360

HPEEQDEVSC LVKGLMRTSI GHPDARPEAP ATSGPAPVSL VETAAEDSSP RGTLASSGDG 420

FEEGLTVATV VESALCALRN CVAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 480

SSRRVAVLFN DGTHMALSAN RKTVHYNPTS TKHFSFSVGA VPRALQPQLG ILRYFASYME 540

QHLMKGGDLP SVEEVEVPGP PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWEP 600

LLVTFVARNR SACTYLASHL RQLGCSPDLK QRLRYALRLL RDRSPA 646

Nucleotide Sequence
(FASTA)

ATGGAGCCCG CCGCGGGCTT CCTGTCCCCG CGCCCTTTCC CGCGTGCTGC CGCCCCGCCC 60

GCACCCCCCG CTCGACCGGG GCCGCCTCCG AGTGCCTTGC CCAGATCTGA GCAGGAGATG 120

CTGGCTGGGC CGCCGGCGCC AGATCCTGGG CGCCTCATCA CGGACCCGAG CAGCGGTCGC 180

ACCTACTTCA AAGGCCGGTT GTTGGGCAAG GGGGGCTTCG CCCGCTGTTA CGAGGCCACT 240

GACACAGAGA CCCGCAGCGC CTATGCGGTC AAAGTCATCC CGCAGAGCCG CGTCGCCAAG 300

CCGCATCAAC GCGAGAAGAT CCTAAATGAG ATTGAGCTGC ACCGAGACCT GCAGCACCGC 360

CATATCGTTC GTTTTTCTCA CCACTTCGAG GATGCTGACA ACATATACAT TTTCCTGGAG 420

CTCTGCAGCA GAAAGTCCCT AGCCCACATC TGGAAGGCAC GGCACACCCT GTTGGAACCA 480

GAGGTGCGCT ACTACCTGCG GCAGATCCTT TCTGGCCTCA AGTACTTGCA CCAGCGGGGC 540

ATCTTGCACC GGGACCTCAA GCTAGGAAAT TTTTTCATCA CAGATAACAT GGAATTGAAG 600

GTGGGGGATT TTGGGCTGGC AGCTCGCTTA GAGCCCCCAG AGCAGAGGAA GAAAACCATC 660

TGTGGCACCC CCAACTATGT GGCTCCAGAA GTGCTACTGA GACAGGGCCA TGGCCCTGAG 720

GCGGATGTGT GGTCACTGGG TTGTGTCATG TACACACTGC TCTGTGGGAC TCCCCCCTTT 780

GAGACTGCTG ACCTGAAAGA AACGTACCGC TGCATCAAGC AGGTTCACTA CACGCTGCCT 840

GCCAGCCTCT CATTGTCTGC CCGGCAGCTC CTGGCCGCCA TTCTTCGAGC CTCACCCCGA 900

GACCGTCCCT CTATTGACCA AATCTTGCGC CATGACTTCT TTACCAAGGG CTACACCCCT 960

GACCGGCTTC CTGTCAGCAG TTGCATAACA GTCCCGGACT TGACACCCCC TAACCCAGCA 1020

AGGAGTCTGT TTGCCAAAGT TACCAAGAGC CTGTTTGGAA GGAAGAAGAA GAATAAAAAC 1080

CATCCTGAGG AGCAGGACGA GGTCTCCTGT TTGGTGAAAG GCCTCATGCG CACGTCTATT 1140

GGCCATCCAG ATGCCAGGCC CGAGGCTCCA GCAACTTCTG GTCCAGCCCC TGTCAGCCTG 1200

GTAGAGACAG CTGCTGAAGA CAGCTCACCC CGTGGGACGC TGGCAAGCAG TGGAGATGGA 1260

TTTGAAGAAG GTCTAACTGT GGCCACTGTG GTAGAGTCAG CCCTCTGTGC TCTGAGAAAC 1320

TGTGTGGCCT TCATGCCCCC AGCGGAACAG AACCCAGCCC CTCTGGCACA GCCAGAGCCT 1380

CTGGTGTGGG TCAGCAAGTG GGTTGATTAC TCCAACAAAT TTGGCTTTGG GTATCAACTG 1440

TCCAGCCGCC GGGTAGCAGT GCTTTTCAAT GATGGCACAC ACATGGCCTT GTCAGCCAAC 1500

AGGAAGACTG TGCACTACAA CCCCACCAGC ACAAAGCACT TCTCTTTCTC TGTGGGTGCT 1560

GTACCTCGAG CTCTGCAACC TCAGCTGGGC ATCCTACGAT ATTTTGCCTC CTACATGGAG 1620

CAGCACCTCA TGAAGGGTGG AGATCTGCCC AGTGTGGAAG AGGTGGAGGT GCCTGGCCCA 1680

CCCTTGCTGC TGCAGTGGGT CAAGACTGAT CAGGCCCTCC TCATGCTATT TAGTGATGGC 1740

ACTGTCCAGG TGAACTTCTA TGGGGACCAC ACCAAGCTGA TCCTCAGCGG CTGGGAGCCC 1800

CTCCTTGTGA CTTTTGTGGC CCGAAATCGC AGTGCTTGTA CTTACCTCGC TTCCCACCTC 1860

CGGCAGCTGG GCTGCTCCCC GGACCTGAAG CAGCGACTCC GATATGCTCT GCGGCTGCTC 1920

AGGGACCGTA GTCCAGCCTA G 1941

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y +g+llGkGgfa+cye++d+et++++avkv+p+s++ak++qrek+ +eie+hr+l+h++

Q: 62    YFKGRLLGKGGFARCYEATDTETRSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH  121

         789*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv+++++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh++ i

Q: 122   IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI  181

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+++++e+k+gdfGla+rle++e+rkkt+cGtPny+aPevl ++gh+ e+

Q: 182   LHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA  241

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytll+G+PPfet++lkety++ik+ +y+lP+sls +a++l+a++l+++P++

Q: 242   DVWSLGCVMYTLLCGTPPFETADLKETYRCIKQVHYTLPASLSLSARQLLAAILRASPRD  301

         ************************************************************

S: 241   rpsleevlkdefl  253

         rps++++l+++f+

Q: 302   RPSIDQILRHDFF  314

         ************8

Domain Sequence
(FASTA)

YFKGRLLGKG GFARCYEATD TETRSAYAVK VIPQSRVAKP HQREKILNEI ELHRDLQHRH 60

IVRFSHHFED ADNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRGI 120

LHRDLKLGNF FITDNMELKV GDFGLAARLE PPEQRKKTIC GTPNYVAPEV LLRQGHGPEA 180

DVWSLGCVMY TLLCGTPPFE TADLKETYRC IKQVHYTLPA SLSLSARQLL AAILRASPRD 240

RPSIDQILRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013