EKS-ICT-00255

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00255

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	437.4	3.2E-131	219	515	297

Status

Unreviewed

Ensembl Protein

ENSSTOP00000005796

UniProt Accession

I3M7Z9;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000006481	ENSSTOP00000005796	ENSSTOT00000006482

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

545

Protein Sequence
(FASTA)

MQLLPPLTLT RTQTQMDDKK PRKPSLTSFP ILKAKKKQNF TSVKVENKPL AQVQKPPSKI 60

KNLKMTRLLH KNTNITSLPF MDTKEKKNVI NLPHISNKIL LKPGVLSREI QTHSHKLASE 120

YKALEAPFHP SMKTHEHKVE EKPPKKHKVP LMAAEALKNF KSKLSPYEQS EILGYTELWF 180

LGLDAEKLNV APEKFSKTSF DDEHGSYLKV LHDHIAYRYE VLEMIGKGSF GQVAKCLDHK 240

NNELVALKII RNKKRFHHQA LVELRILEAL RRKDKDNKYN VVHMKDFFYF RNHLCITFEL 300

LGINLYELMK SNSFQGFSLS VVRRFTLSVL KCLQMLYVEK IIHCDLKPEN IVLYQKGQIT 360

VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYNMAI DMWSLGCILA ELYTGYPLFP 420

GENEVEQLAC IMEVLGLPPA HFIQTASRRQ TFFDSKGFPK TITNNRGKKR YPDSKDLTMV 480

LKTYDTSFLD FLRRCLVWEP SLRMTPDQAL KHAWIHEPRN LKPRPRPQAL RKPNVTLPSE 540

ISKNK 545

Nucleotide Sequence
(FASTA)

ATGCAGCTCC TCCCACCTCT TACCCTCACC CGGACCCAGA CTCAAATGGA CGATAAAAAG 60

CCAAGGAAAC CGAGTTTGAC TTCCTTCCCA ATTTTGAAAG CAAAAAAGAA GCAAAATTTC 120

ACCTCTGTGA AGGTTGAAAA TAAGCCTTTG GCTCAAGTCC AGAAGCCACC CTCCAAGATC 180

AAGAACCTCA AAATGACCCG ACTTTTGCAT AAAAACACCA ACATTACTTC ACTCCCTTTT 240

ATGGATACCA AGGAGAAGAA GAATGTGATC AACCTCCCAC ACATCAGCAA CAAAATTCTG 300

CTGAAGCCAG GTGTGCTGTC CCGGGAAATT CAAACACACA GTCATAAGCT GGCCTCTGAG 360

TACAAGGCTT TAGAAGCACC TTTCCACCCT AGCATGAAGA CTCATGAACA CAAGGTAGAA 420

GAGAAACCAC CAAAGAAGCA CAAGGTGCCT CTGATGGCAG CAGAAGCCCT AAAGAATTTT 480

AAGAGTAAGC TGTCTCCTTA TGAGCAAAGT GAAATCCTGG GCTACACAGA GCTATGGTTC 540

CTGGGGCTTG ATGCTGAGAA ACTCAATGTG GCTCCAGAGA AATTCAGCAA GACAAGTTTT 600

GATGATGAAC ATGGCTCCTA TCTGAAGGTC CTGCATGACC ACATTGCCTA CCGCTACGAG 660

GTTCTGGAGA TGATTGGAAA AGGGTCCTTT GGACAGGTGG CCAAGTGCTT GGATCACAAA 720

AACAATGAGT TGGTGGCCCT GAAAATCATC AGGAACAAAA AGAGATTTCA CCACCAGGCC 780

CTGGTGGAGC TGAGGATCCT GGAAGCCCTC AGAAGGAAGG ATAAAGACAA CAAGTACAAT 840

GTGGTACACA TGAAGGACTT TTTCTACTTC CGAAATCACC TCTGCATCAC CTTTGAACTT 900

TTGGGAATCA ACTTGTATGA GTTGATGAAG AGTAATAGCT TTCAAGGTTT TAGTCTATCG 960

GTAGTTCGGC GCTTCACCCT CTCTGTCTTG AAGTGCTTGC AAATGCTTTA CGTAGAGAAA 1020

ATCATCCACT GTGATCTCAA GCCTGAAAAT ATAGTGCTAT ACCAAAAGGG CCAAATCACA 1080

GTTAAAGTTA TTGACTTTGG GTCCAGTTGT TATGAGCACC AGAAAGTATA CACCTATATC 1140

CAAAGCCGGT TCTACCGATC CCCTGAAGTG ATTCTGGGTC ACCCCTACAA TATGGCCATT 1200

GATATGTGGA GCCTGGGCTG CATCTTGGCA GAGCTGTACA CGGGTTACCC TCTGTTCCCA 1260

GGGGAGAATG AGGTGGAGCA GCTGGCCTGC ATCATGGAGG TGCTGGGTCT GCCGCCAGCC 1320

CACTTCATTC AGACGGCCTC CAGGAGACAG ACGTTCTTTG ATTCCAAAGG TTTTCCTAAA 1380

ACTATAACCA ACAACAGGGG GAAAAAAAGA TACCCGGATT CCAAGGATCT CACGATGGTG 1440

CTGAAAACCT ATGACACCAG CTTCCTGGAC TTTCTCAGAA GGTGTTTGGT ATGGGAACCT 1500

TCTCTTCGTA TGACCCCTGA TCAGGCCCTC AAGCATGCTT GGATTCATGA GCCACGGAAC 1560

CTCAAACCAC GGCCCAGGCC CCAGGCCCTG AGGAAACCCA ATGTCACTCT TCCTTCTGAG 1620

ATAAGCAAGA ACAAG 1635

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle+igkGsfgqV+k+ld+k++e va+kii+nkkrf++qa  E++iLe+l++kdk++k

Q: 219   YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELRILEALRRKDKDNK  278

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         ynvv+++++f+frnhlc++fell +nLyel+k n+f+g+sl++vr+++ ++lk+L++L+

Q: 279   YNVVHMKDFFYFRNHLCITFELLGINLYELMKSNSFQGFSLSVVRRFTLSVLKCLQMLYV  338

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNi+l++k++ +vkviDFGss++++qk +ytyiqsrfYr+PE+ilg++y+

Q: 339   EKIIHCDLKPENIVLYQKGQITVKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHPYN  397

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         +aiDmWSlGc+laEl+tG+pLfpGenev+qla+i+evlglpp++++++a+++++ff++k+

Q: 398   MAIDMWSLGCILAELYTGYPLFPGENEVEQLACIMEVLGLPPAHFIQTASRRQTFFDSKG  457

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +pk i++                +  k+++p sk+l+++lk+++++ f d+l+r+l ++p

Q: 458   FPKTITN----------------NRGKKRYPDSKDLTMVLKTYDTS-FLDFLRRCLVWEP  500

         **97773................34467899999**9999998877.*************

S: 301   akRitpkealkhpfv  315

         + R+tp++alkh ++

Q: 501   SLRMTPDQALKHAWI  515

         *************97

Domain Sequence
(FASTA)

YEVLEMIGKG SFGQVAKCLD HKNNELVALK IIRNKKRFHH QALVELRILE ALRRKDKDNK 60

YNVVHMKDFF YFRNHLCITF ELLGINLYEL MKSNSFQGFS LSVVRRFTLS VLKCLQMLYV 120

EKIIHCDLKP ENIVLYQKGQ ITVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYNM 180

AIDMWSLGCI LAELYTGYPL FPGENEVEQL ACIMEVLGLP PAHFIQTASR RQTFFDSKGF 240

PKTITNNRGK KRYPDSKDLT MVLKTYDTSF LDFLRRCLVW EPSLRMTPDQ ALKHAWI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013