EKS-ICT-00280
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00280
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR498.24.5E-150710967258
StatusUnreviewed
Ensembl ProteinENSSTOP00000006038
UniProt AccessionI3M8G8;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000006716ENSSTOP00000006038ENSSTOT00000006753
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length1199
Protein Sequence
(FASTA)
MRPSRTAGAA LLVLLAALVW ASCALEEKKV CQGTSNKLTQ LGTCEDHFLS LQRMFNNCEV 60
VLGNLEITYV QKNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN VLYENTYALA 120
VLSNYGENRT GLRELPMRNL QEILHGAVRF SNNPVLCNME SIQWQDIVDN DFMSNMSMDL 180
QNRLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC 240
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300
VTDHGSCVRA CGPDSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360
NCTSISGDLH ILPVAFKGDS YTRTPPLDPK ELDILKTVKE ITGFLLIQAW PENKTDLHAF 420
ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 480
FGTSSQKTKI INNRDEKDCK NRGHFCNPLC SSEGCWGPEP RDCVSCQNVS RGKECVEKCN 540
VLEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGAQAVC GELKVHPLPS GMSAPVHEHN 600
LHITFLYQES KVMTCLLCSI PCTKKCAGPG LQGCTINGPK IPSIATGIVG GLFLLVIVAL 660
GIGLFMRRRH IVRKRTLRRL LQERELVEPL TPSGEAPNQA LLRILKETEF KKIKVLGSGA 720
FGTVYKGLWI PEGEKVKIPV AIKELREATS PKANKEILDE AYVMASVDNP HVCRLLGICL 780
TSTVQLITQL MPFGCLLDYV REHKDNIGSQ YLLNWCVQIA KGMNYLEDRR LVHRDLAARN 840
VLVKTPQHVK ITDFGLAKLL GAEEKEYHAE GGKVPIKWMA LESILHRIYT HQSDVWSYGV 900
TVWELMTFGS KPYDGIPASE ISSILEKGER LPQPPICTID VYMIMVKCWM IDADSRPKFR 960
ELIVEFSKMA RDPQRYLVIQ GDERMHLPSP TDSNFYRALM DEDDMEDVVD ADEYLIPQQG 1020
FFNSPSTSRT PLLSSLSATS NNSTVACINR NGSCPTKEDS FLQRYSSDPT GALTEDSIDD 1080
TFLPAPEYIN QSIPKRPAGS VQNPVYHNQP LHPAAGRDPH YQNPHSNAVG NPEYLNTTQP 1140
ICVNSAFDSS AHWAQKGNHQ ISLDNPDYQQ DFLPKESKPN GIFKGPTAEN AEYLRVAPP 1199
Nucleotide Sequence
(FASTA)
ATGCGACCCT CCAGGACCGC CGGAGCCGCG CTGCTGGTGC TGCTAGCTGC GCTGGTATGG 60
GCGAGTTGTG CGTTGGAGGA AAAGAAAGTT TGCCAAGGCA CAAGTAACAA GCTCACCCAG 120
TTGGGCACTT GTGAAGATCA CTTTCTGAGC CTCCAGAGGA TGTTCAATAA CTGTGAAGTG 180
GTCCTGGGGA ACTTGGAAAT TACCTACGTG CAAAAGAATT ATGACCTTTC CTTCTTAAAG 240
ACCATCCAGG AAGTTGCTGG TTATGTACTC ATTGCCCTCA ACACAGTGGA GAGGATTCCT 300
TTGGAAAACC TGCAGATCAT CAGAGGAAAT GTGCTCTATG AAAATACTTA TGCCTTAGCA 360
GTCCTGTCTA ACTATGGTGA AAATAGAACT GGACTAAGGG AGCTGCCCAT GAGAAACTTA 420
CAGGAAATCC TGCATGGTGC TGTGCGGTTC AGCAATAACC CTGTCCTCTG CAACATGGAA 480
AGCATCCAGT GGCAGGATAT CGTCGACAAT GACTTTATGA GCAATATGTC AATGGACTTG 540
CAGAACCGCC TGGGCAGCTG CCAAAAGTGT GATCCAAGCT GTCCCAATGG AAGCTGCTGG 600
GGGGCAGGAG AGGAAAACTG CCAGAAATTG ACCAAGATCA TCTGTGCCCA GCAGTGCTCA 660
GGGCGCTGCC GTGGCAAGTC CCCCAGTGAC TGCTGTCATA ACCAGTGTGC AGCTGGCTGC 720
ACGGGGCCCC GGGAGAGCGA CTGCCTGGTC TGCCGCAAGT TCCGAGATGA AGCAACATGC 780
AAGGACACCT GTCCACCACT CATGCTGTAC AACCCCACCA CATACCAGAT GGATGTCAAC 840
CCCGAGGGGA AGTATAGCTT CGGTGCCACC TGTGTGAAGA AGTGTCCCCG GAACTATGTG 900
GTGACAGACC ATGGCTCCTG TGTCCGCGCC TGTGGTCCTG ATAGCTATGA GATGGAGGAG 960
GATGGTGTTC GCAAGTGTAA GAAGTGTGAA GGGCCGTGTC GCAAAGTTTG TAACGGAATA 1020
GGAATTGGTG AATTTAAAGA CACACTTTCC ATAAATGCTA CAAACATAAA GCACTTCAAA 1080
AACTGTACTT CTATCAGTGG AGATCTTCAT ATCCTGCCAG TAGCATTTAA GGGGGACTCC 1140
TACACACGTA CTCCTCCTCT AGATCCAAAG GAACTGGATA TTCTAAAAAC CGTAAAGGAA 1200
ATAACAGGGT TTTTGCTGAT TCAAGCGTGG CCTGAAAACA AGACTGACCT CCATGCTTTT 1260
GAGAACCTAG AAATCATACG TGGCAGGACA AAGCAACATG GTCAGTTTTC TCTAGCAGTT 1320
GTTGGCCTGA ACATAACATC CTTGGGATTA CGCTCCCTGA AGGAGATAAG TGATGGAGAT 1380
GTGATAATTT CAGGAAACCG AAATTTGTGC TATGCAAACA CAATAAACTG GAAAAAACTA 1440
TTTGGGACTT CCAGTCAGAA AACCAAAATT ATAAACAACA GAGATGAAAA AGACTGCAAG 1500
AACAGAGGCC ACTTCTGTAA TCCCTTGTGC TCATCTGAGG GCTGCTGGGG CCCTGAGCCC 1560
AGAGACTGTG TCTCCTGCCA AAATGTCAGC CGAGGCAAGG AGTGTGTGGA GAAGTGCAAC 1620
GTTCTGGAGG GGGAGCCCAG GGAGTTTGTG GAGAATTCCG AGTGCATCCA GTGCCATCCG 1680
GAATGTCTGC CCCAGACCAT GAACATAACC TGCACAGGCC GGGGAGCCCA GGCAGTTTGT 1740
GGAGAATTAA AAGTGCATCC ATTGCCTTCC GGAATGTCTG CCCCAGTCCA TGAACATAAT 1800
TTGCACATAA CCTTTTTATA TCAGGAATCA AAAGTAATGA CCTGTCTGCT TTGTTCAATT 1860
CCCTGTACAA AGAAATGTGC TGGACCAGGG CTTCAAGGCT GTACAATAAA TGGACCCAAG 1920
ATCCCATCCA TTGCCACTGG GATTGTGGGT GGTCTCTTCT TGCTGGTGAT AGTGGCCCTT 1980
GGGATTGGCC TTTTCATGAG AAGGCGTCAC ATTGTCAGGA AGCGCACGCT GCGTAGACTG 2040
CTGCAGGAGA GAGAGCTTGT GGAGCCTCTG ACGCCCAGTG GAGAAGCCCC CAACCAAGCT 2100
CTCCTGAGGA TCTTAAAGGA AACAGAATTC AAAAAGATAA AAGTACTGGG CTCAGGAGCA 2160
TTTGGCACTG TGTATAAGGG ACTCTGGATT CCAGAAGGTG AGAAAGTTAA AATTCCGGTA 2220
GCAATCAAAG AATTAAGAGA AGCCACGTCT CCAAAAGCCA ACAAGGAAAT TCTTGACGAA 2280
GCCTATGTGA TGGCCAGTGT GGACAATCCT CATGTGTGCC GCCTCCTGGG TATCTGTCTG 2340
ACCTCCACCG TCCAGCTTAT CACTCAGCTC ATGCCCTTTG GTTGCCTCCT GGACTATGTC 2400
CGAGAACACA AGGACAACAT CGGTTCCCAG TACCTACTCA ACTGGTGTGT GCAGATTGCA 2460
AAGGGCATGA ACTACCTGGA AGACCGGCGC TTGGTGCATC GTGACCTGGC AGCCAGGAAT 2520
GTCCTAGTGA AGACACCACA GCATGTCAAG ATCACAGATT TTGGACTGGC CAAACTGCTT 2580
GGGGCTGAGG AGAAAGAATA CCATGCAGAG GGAGGAAAGG TGCCTATCAA GTGGATGGCT 2640
TTGGAATCAA TTTTACACCG AATTTATACC CACCAAAGTG ATGTCTGGAG CTATGGAGTC 2700
ACTGTTTGGG AGTTGATGAC TTTTGGGTCC AAGCCTTATG ATGGAATCCC TGCAAGTGAG 2760
ATCTCATCCA TCCTAGAAAA AGGAGAGCGC CTTCCACAGC CTCCCATCTG CACCATTGAT 2820
GTCTACATGA TCATGGTCAA GTGCTGGATG ATAGATGCAG ACAGTCGCCC AAAGTTCCGG 2880
GAGTTGATCG TGGAATTCTC CAAAATGGCT CGAGATCCCC AGCGCTATCT TGTCATACAG 2940
GGGGATGAAA GAATGCATTT GCCAAGCCCT ACAGACTCCA ATTTTTATCG TGCCCTGATG 3000
GATGAAGATG ACATGGAAGA TGTGGTGGAT GCTGATGAGT ACCTCATTCC ACAACAGGGC 3060
TTCTTCAACA GCCCATCTAC ATCTCGGACT CCCCTCTTAA GTTCTCTGAG TGCAACCAGC 3120
AACAATTCCA CTGTGGCTTG CATTAACAGA AATGGGAGTT GTCCCACAAA GGAGGACAGC 3180
TTCTTGCAGC GGTACAGCTC AGACCCAACT GGTGCCTTGA CAGAGGACAG CATAGATGAT 3240
ACATTCCTCC CAGCACCTGA ATATATAAAC CAGTCTATTC CTAAGAGGCC TGCAGGATCT 3300
GTGCAGAACC CTGTCTATCA CAATCAACCC TTGCATCCAG CAGCTGGCAG AGACCCACAC 3360
TACCAAAATC CCCACAGTAA CGCCGTGGGC AACCCTGAAT ATCTCAACAC CACCCAGCCT 3420
ATTTGTGTCA ACAGTGCATT TGACAGCTCT GCCCACTGGG CCCAGAAAGG CAACCACCAA 3480
ATTAGCCTGG ACAACCCTGA CTACCAACAG GACTTCTTGC CCAAGGAATC CAAGCCAAAT 3540
GGCATCTTTA AGGGTCCCAC AGCTGAAAAT GCAGAATACC TACGAGTAGC ACCACCA 3597
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 710   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  769
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++
Q: 770   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR  829
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y
Q: 830   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  889
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw
Q: 890   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  949
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el+ efs
Q: 950   MIDADSRPKFRELIVEFS  967
         ****************96
Domain Sequence
(FASTA)
FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QYLLNWCVQI AKGMNYLEDR 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELIVEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00290
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CIS-00072
EKS-EQC-00289
EKS-FEC-00283
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORN-00386
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-PEM-00164
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013