EKS-ICT-00348

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00348

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	442.9	2.9E-133	247	497	251

Status

Unreviewed

Ensembl Protein

ENSSTOP00000006083

UniProt Accession

I3M8K4;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000006783	ENSSTOP00000006083	ENSSTOT00000006804

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCIKSKRKD NLNDDGIDMK TQPVRNTDRT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 60

PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLSTKRE GFIPSNYVAK 120

VNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSYSLSVR DYDPMHGDVI 180

KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW 240

EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300

KLVRLYAVVT KEEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360

KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420

TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPD ELYDIMKMCW 480

KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAAT AGATATGAAG 60

ACTCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120

CAGCAAAGGC CAGTTCCAGA ATCTCAGCTT TTACCAGGAC AGAGGTTTCA AACGAAAGAT 180

CCAGAGGAGC AAGGCGACAT TGTGGTGGCC TTGTACCCCT ATGATGGCAT ACACCCCGAT 240

GACCTGTCTT TCAAGAAAGG AGAGAAGATG AAAGTCCTGG AGGAGCATGG AGAATGGTGG 300

AAAGCTAAGT CCCTTTCAAC AAAGAGAGAG GGCTTCATCC CCAGCAACTA CGTGGCCAAA 360

GTCAACACCT TAGAAACAGA AGAGTGGTTT TTCAAGGATA TCACCAGGAA AGATGCGGAA 420

CGACAGCTTT TGGCACCCGG GAACAGCGCA GGAGCTTTTC TTATCAGAGA AAGTGAAACA 480

TTAAAAGGAA GCTACTCTCT TTCTGTCAGA GACTATGACC CCATGCATGG TGATGTTATC 540

AAGCACTACA AAATTAGAAG TCTGGATAAT GGAGGTTATT ACATCTCTCC ACGAATCACC 600

TTTCCCTGCA TCAGTGACAT GATTAAGCAT TACCAAAAGC AATCAGATGG CTTATGCAGA 660

AGATTGGAGA AGGCTTGTAT TAGTCCCAAA CCACAGAAGC CATGGGATAA AGATGCCTGG 720

GAAATCCCTC GAGAGTCCAT TAAGTTGGTG AAAAGGCTCG GCGCTGGACA GTTTGGGGAA 780

GTCTGGATGG GTTACTATAA CAACAGCACC AAGGTGGCTG TGAAGACCCT GAAGCCTGGC 840

ACCATGTCTG TGCAAGCATT CCTCGAAGAA GCAAACCTCA TGAAGACTCT TCAGCATGAC 900

AAACTGGTGA GACTCTACGC CGTGGTCACC AAGGAGGAGC CCATTTATAT CATCACCGAG 960

TACATGGCCA AAGGCAGTTT GCTGGATTTC CTCAAGAGTG ATGAAGGTGG CAAAGTGCTG 1020

CTCCCAAAGC TCATCGACTT TTCTGCTCAG ATTGCAGAGG GCATGGCTTA CATTGAGCGG 1080

AAGAACTACA TCCACCGTGA CCTGCGAGCA GCTAATGTCC TGGTATCTGA GTCACTCATG 1140

TGCAAGATTG CAGATTTTGG TCTTGCTAGA GTCATTGAAG ACAACGAGTA CACAGCAAGG 1200

GAAGGTGCTA AGTTTCCTAT TAAGTGGACA GCTCCAGAAG CAATCAACTT TGGATGTTTC 1260

ACTATCAAGT CTGATGTATG GTCCTTTGGA ATTCTCCTGT ACGAAATCGT CACCTACGGG 1320

AAGATTCCCT ACCCAGGGAG AACCAATGCT GATGTGATGA CTGCCCTGTC TCAGGGTTAC 1380

CGGATGCCCC GCATGGAGAA CTGCCCAGAT GAGCTCTATG ACATTATGAA GATGTGCTGG 1440

AAAGAAAAGG CAGAGGAGAG ACCAACGTTT GATTACTTAC AGAGTGTCCT GGATGATTTC 1500

TACACAGCCA CGGAAGGGCA GTATCAGCAG CAGCCTTAG 1539

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 307   AVVTKEEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr+e+cp+ely+++++cwk+++ee

Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMENCPDELYDIMKMCWKEKAEE  486

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 487   RPTFDYLQSVL  497

         ********986

Domain Sequence
(FASTA)

IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTKEEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180

WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRME NCPDELYDIM KMCWKEKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013