EKS-ICT-00371

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00371

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.8	2.4E-97	826	1090	265

Status

Unreviewed

Ensembl Protein

ENSSTOP00000006441

UniProt Accession

I3M9A6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007184	ENSSTOP00000006441	ENSSTOT00000007207

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1095

Protein Sequence
(FASTA)

MSNSHTLSSS STSTSSSENS IKDEEEQMCP ICLLGMLDEE SLTVCEDGCR NKLHHHCMSI 60

WAEECRRNRE PLICPLCRSK WRSHDFYSHE LSSPVDSPSS LRAAQQQTTQ QQPLAGSQRR 120

NQESNFNLTH YGTQQIPPAY KDLAEPWIQV FGMELVGCLF SRNWNVREMA LRRLSHDVSG 180

ALLLANGEST GNSGGSGGSS PNAGATSGSS QASISGDVVE ACCSVLSMVC ADPVYKVYVA 240

ALKTLRAMLV YTPCHSLAER IKLQRLLRPV VDTILVKCAD ANSRTSQLSI STLLELCKGQ 300

AGELAVGREI LKAGSIGIGG VDYVLNCILG NQTESNNWQE LLGRLCLIDR LLLEFPAEFY 360

PHIVSTDVSQ VEPVEIRYKK LLSLLTFALQ SIDNSHSMVG KLSRRIYLSS ARMVTAVPHV 420

FSKLLEMLNV SSSTHFTRMR RRLMAIADEV EIAEAIQLGI EDTLDGRQDS FLQASASNSY 480

PETTENSCLE RTVHLEKTGK GLCATKLSAS SEDISDRLAS ISVGLHSSTT TMEQPKPMVQ 540

TKGRPHSQCL NSSPLSHHSQ LMFPGSSTPS SSAPSVPAGS VTDASKNRPQ GFIPCKIPSA 600

SPQTQRKFSL QFQRNCSENK DSDKLSPIFT QSRPLPSSNI HRPKPSRPTP GNTSKQGDVS 660

KNSMTLDLNS TSKCDDSFGS SSNSSNAVIP SDETVFTPVE EKCRLDVNTE LNSSIEDLLE 720

ASMPSSDTTV TFKSEVAVLS PEKSESDDTY KDDVNHNQKC KEKMEAEEEE ALAIAMAMSA 780

SQDALPMVPQ LQVENGEDII IIQQDTPETL PGHTKAKQPY REDTEWLKGQ QIGLGAFSSC 840

YQAQDVGTGT LMAVKQVTYV RNTSSEQEEV VEALREEIRM MSHLNHPNII RMLGATCEKS 900

NYNLFIEWMA GGSVAHLLSK YGAFKESVVI NYTEQLLRGL SYLHENQIIH RDVKGANLLI 960

DSTGQRLRIA DFGAAARLAS KGTGAGEFQG QLLGTIAFMA PEVLRGQQYG RSCDVWSVGC 1020

AIIEMACAKP PWNAEKHSNH LALIFKIASA TTAPSIPSHL SPGLRDVALR CLELQPQDRP 1080

PSRELLKHPV FRTTW 1095

Nucleotide Sequence
(FASTA)

ATGTCAAATT CTCATACATT GTCATCATCT AGTACTTCTA CATCTAGTTC AGAAAACAGC 60

ATAAAGGATG AAGAAGAGCA AATGTGTCCT ATTTGCTTGT TGGGCATGCT TGACGAAGAA 120

AGTCTTACAG TGTGTGAAGA TGGCTGCCGG AACAAGCTGC ACCACCACTG CATGTCCATC 180

TGGGCAGAAG AATGTAGAAG AAATAGAGAA CCTTTAATAT GTCCCCTTTG TAGGTCTAAG 240

TGGAGATCCC ACGATTTCTA CAGCCATGAG TTGTCAAGTC CCGTGGATTC CCCTTCTTCC 300

CTGCGTGCTG CACAACAGCA AACCACACAG CAGCAGCCTT TGGCTGGATC ACAAAGAAGG 360

AATCAAGAGA GCAATTTTAA CCTTACTCAT TATGGAACTC AGCAGATCCC TCCTGCTTAT 420

AAGGATTTAG CTGAGCCATG GATTCAGGTG TTTGGAATGG AACTCGTTGG CTGCTTATTT 480

TCTAGAAACT GGAATGTAAG AGAGATGGCC CTCAGGCGTC TTTCCCATGA TGTTAGTGGG 540

GCCCTGCTGT TGGCCAATGG GGAGAGCACT GGAAATTCTG GGGGCAGTGG TGGAAGCAGC 600

CCAAATGCTG GAGCCACTAG CGGGTCTTCC CAGGCCAGCA TCTCAGGAGA TGTGGTGGAG 660

GCCTGCTGCA GCGTCTTATC AATGGTCTGT GCTGACCCTG TCTACAAAGT GTACGTTGCT 720

GCTTTAAAAA CTTTGAGAGC CATGCTGGTA TATACTCCTT GCCACAGTTT GGCAGAGAGA 780

ATCAAACTTC AGAGACTTCT CCGGCCAGTT GTAGACACCA TCCTAGTCAA GTGTGCAGAT 840

GCCAATAGCC GTACAAGTCA GCTGTCCATA TCAACACTGT TGGAATTGTG TAAAGGCCAA 900

GCAGGAGAGC TGGCAGTTGG TAGAGAAATA CTTAAAGCGG GATCCATTGG TATTGGTGGT 960

GTTGATTATG TCTTAAATTG TATTCTTGGA AACCAAACTG AATCGAACAA CTGGCAGGAA 1020

CTCCTGGGCC GTCTTTGTCT TATTGATAGA CTGTTATTGG AATTTCCTGC TGAATTTTAT 1080

CCTCATATTG TCAGTACTGA TGTTTCACAA GTTGAGCCTG TTGAAATCAG GTATAAGAAG 1140

CTGCTGTCCC TCTTAACCTT TGCCTTGCAG TCCATTGATA ATTCCCACTC AATGGTTGGT 1200

AAACTCTCTC GAAGGATATA TTTGAGTTCT GCAAGAATGG TTACCGCAGT ACCCCATGTG 1260

TTTTCAAAAC TGTTAGAAAT GCTGAATGTT TCCAGTTCTA CTCACTTCAC CAGGATGCGT 1320

CGTCGTTTGA TGGCTATTGC TGATGAGGTG GAAATTGCTG AGGCCATCCA GCTGGGCATA 1380

GAAGACACCT TGGATGGTCG ACAGGACAGC TTTTTGCAAG CATCTGCCTC TAATAGCTAT 1440

CCAGAAACCA CAGAGAACAG TTGCCTTGAG CGCACAGTAC ATTTAGAGAA AACTGGAAAA 1500

GGATTATGTG CTACAAAATT GAGTGCCAGT TCAGAGGACA TTTCTGACAG ACTGGCCAGC 1560

ATTTCAGTAG GACTTCACAG TTCCACTACA ACAATGGAGC AACCAAAGCC AATGGTTCAA 1620

ACAAAAGGCA GGCCCCACAG TCAATGTTTG AACTCCTCTC CTTTGTCTCA TCATTCCCAA 1680

TTAATGTTCC CAGGCTCATC GACCCCTTCT TCATCAGCCC CATCTGTACC AGCTGGCTCT 1740

GTAACAGATG CCTCCAAGAA TAGACCTCAG GGTTTTATTC CCTGCAAAAT ACCTTCTGCA 1800

TCTCCTCAAA CACAACGCAA GTTTTCTCTA CAATTCCAGA GAAACTGTTC TGAAAACAAA 1860

GACTCAGATA AACTTTCTCC AATCTTTACT CAGTCAAGAC CCTTACCCTC CAGTAACATA 1920

CACAGGCCAA AGCCATCTCG ACCCACCCCT GGTAATACAA GTAAACAGGG AGATGTTTCA 1980

AAAAATAGCA TGACACTTGA TCTAAACAGT ACTTCCAAAT GTGATGACAG CTTTGGCAGT 2040

AGCAGCAATA GTAGTAATGC TGTTATACCC AGTGACGAGA CAGTGTTCAC ACCAGTAGAG 2100

GAGAAATGCA GATTAGATGT CAATACAGAA CTCAATTCCA GTATTGAAGA CCTTCTTGAG 2160

GCATCTATGC CCTCAAGTGA CACAACAGTC ACTTTTAAGT CAGAAGTTGC TGTCCTCTCT 2220

CCTGAAAAGT CTGAAAGTGA TGATACCTAC AAAGATGATG TGAATCATAA TCAAAAGTGC 2280

AAAGAAAAAA TGGAAGCTGA AGAAGAAGAA GCTTTAGCAA TTGCCATGGC AATGTCAGCG 2340

TCTCAGGATG CCCTCCCCAT GGTTCCTCAA CTACAGGTTG AAAATGGAGA AGATATTATC 2400

ATTATTCAAC AGGATACACC AGAGACTCTA CCAGGACATA CCAAAGCAAA ACAACCTTAC 2460

AGAGAAGACA CTGAATGGCT GAAAGGTCAG CAGATAGGCC TTGGAGCATT TTCTTCTTGT 2520

TATCAGGCAC AAGATGTGGG TACTGGAACT TTAATGGCTG TTAAACAGGT GACATATGTC 2580

AGAAACACAT CTTCTGAACA AGAAGAAGTT GTTGAAGCAT TAAGAGAAGA GATAAGAATG 2640

ATGAGCCATC TGAATCATCC GAACATCATT AGGATGTTAG GAGCCACATG TGAGAAGAGC 2700

AATTACAATC TCTTTATCGA ATGGATGGCA GGAGGATCTG TGGCTCATCT GCTGAGTAAA 2760

TATGGAGCCT TCAAGGAATC AGTAGTCATT AACTACACTG AACAGTTACT TCGTGGCCTT 2820

TCTTACCTCC ATGAAAACCA GATCATTCAC AGAGATGTCA AAGGTGCCAA TTTGCTAATC 2880

GACAGCACAG GTCAGAGGCT CAGAATTGCA GATTTTGGAG CTGCAGCCAG GTTGGCTTCA 2940

AAAGGAACTG GTGCAGGAGA GTTTCAGGGA CAGTTATTGG GGACAATTGC ATTCATGGCA 3000

CCTGAGGTCC TGAGAGGTCA GCAGTATGGT AGGAGCTGTG ATGTATGGAG TGTTGGCTGT 3060

GCTATTATAG AAATGGCTTG TGCAAAACCA CCTTGGAATG CGGAAAAACA CTCCAATCAC 3120

CTTGCTTTGA TATTTAAGAT TGCTAGTGCA ACTACTGCCC CATCAATCCC TTCACATCTG 3180

TCTCCTGGCT TACGTGATGT GGCTCTTCGT TGTTTAGAAC TTCAACCTCA GGACAGACCT 3240

CCATCAAGAG AGCTACTGAA GCATCCAGTC TTCCGTACAA CATGGTAG 3288

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 826   WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  885

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 886   HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  945

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 946   NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1005

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1006  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1063

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1064  LRDVALRCLELQPQDRPPSRELLKHPV  1090

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.

Prints

Created Date

20-Feb-2013