EKS-ICT-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	508.8	2.4E-153	178	436	259

Status

Unreviewed

Ensembl Protein

ENSSTOP00000006573

UniProt Accession

I3M9K0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007346	ENSSTOP00000006573	ENSSTOT00000007357

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

LVNVKLWAID RQCFQTIMMR TGLIKHTEYM EFLKSVPTFQ SLPEEILSKL ADVLEETHYE 60

NGEYIIRQGA RGDTFFIISK GKVNVTREDS PSEDPVFLRT LGKGDWFGEK ALQGEDVRTA 120

NVIAAEAVTC LVIDRDSFKH LIGGLDDVSN KAYEDAEAKA KYEAEAAFFA NLKLSDFNII 180

DTLGVGGFGR VELVQLKSEE SKTFAMKILK KRHIVDTRQQ EHIRSEKHIM QGAHSDFIVR 240

LYRTFKDSKY LYMLMEVCLG GELWTILRDR GSFEDSTTRF YTACVVEAFA YLHSKGIIYR 300

DLKPENLILD HRGYAKLVDF GFAKKIGFGK KTWTFCGTPE YVAPEIILNK GHDISADYWS 360

LGILMYELLT GSPPFSGPDP MKTYNIILRG IDMIEFPKKI AKNAANLIKK LCRDNPSERL 420

GNLKNGVKDI QKHKWFEGFN WEGLRKGTLT PPIIPSVASP TDTSNFDSFP EDSDEPPPDD 480

NSGWDIDF 488

Nucleotide Sequence
(FASTA)

CTTGTAAATG TGAAACTTTG GGCCATTGAT CGACAATGTT TTCAAACAAT AATGATGAGG 60

ACAGGCCTCA TCAAGCATAC CGAGTACATG GAATTTTTAA AAAGTGTTCC AACATTCCAG 120

AGCCTTCCTG AAGAGATCCT TAGCAAGCTT GCTGATGTCC TTGAAGAGAC TCACTATGAA 180

AATGGGGAAT ATATTATCAG GCAAGGAGCA AGAGGGGACA CCTTCTTTAT CATCAGCAAA 240

GGAAAGGTGA ATGTTACTCG TGAAGACTCA CCTAGTGAAG ACCCAGTCTT TCTTAGGACT 300

TTAGGAAAAG GAGACTGGTT TGGAGAGAAA GCTTTGCAGG GGGAAGACGT GAGAACAGCA 360

AATGTCATTG CCGCAGAAGC TGTAACCTGC CTTGTGATTG ACAGAGACTC TTTCAAGCAT 420

TTGATTGGAG GGCTGGATGA TGTTTCTAAT AAAGCATATG AGGATGCAGA AGCAAAAGCA 480

AAATACGAAG CCGAAGCTGC TTTCTTCGCC AACCTGAAGC TGTCTGATTT CAACATTATT 540

GATACCCTTG GAGTTGGAGG TTTCGGACGA GTAGAACTGG TCCAGTTGAA GAGTGAAGAA 600

TCCAAAACAT TTGCAATGAA GATTCTCAAG AAACGCCACA TTGTGGATAC CAGACAGCAG 660

GAGCACATCC GCTCAGAGAA GCATATCATG CAGGGGGCTC ATTCCGACTT CATAGTGAGG 720

CTATACAGAA CATTTAAGGA CAGCAAATAT TTGTATATGT TGATGGAAGT TTGCCTAGGT 780

GGAGAGCTCT GGACCATTCT CAGGGATAGA GGTTCATTTG AAGATTCTAC AACCAGATTT 840

TACACAGCAT GTGTGGTGGA AGCTTTTGCC TATCTGCATT CCAAAGGAAT CATTTACAGG 900

GACCTCAAGC CAGAAAATCT CATCCTAGAT CATCGAGGTT ATGCCAAACT GGTTGATTTT 960

GGCTTTGCAA AGAAAATAGG ATTTGGAAAG AAAACATGGA CTTTTTGTGG GACTCCAGAG 1020

TATGTAGCCC CAGAGATCAT CTTAAACAAA GGTCATGACA TTTCAGCTGA CTATTGGTCA 1080

TTGGGAATTC TAATGTATGA ACTTCTGACT GGCAGCCCAC CTTTCTCAGG CCCAGATCCT 1140

ATGAAAACCT ATAACATCAT ATTGAGGGGG ATTGACATGA TAGAATTTCC AAAGAAGATT 1200

GCCAAAAATG CTGCTAACTT AATCAAAAAA CTATGCAGGG ACAACCCGTC GGAAAGATTA 1260

GGAAATTTGA AAAATGGAGT GAAAGATATT CAAAAGCACA AATGGTTTGA GGGCTTTAAC 1320

TGGGAAGGTC TGAGGAAGGG CACCTTGACT CCTCCCATCA TACCAAGCGT TGCATCACCC 1380

ACGGACACAA GCAATTTCGA CAGTTTTCCT GAGGACAGTG ACGAGCCACC ACCTGATGAC 1440

AACTCAGGCT GGGATATAGA CTTCTAA 1467

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 178   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKHIMQGAHSDF  237

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+e+clggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 238   IVRLYRTFKDSKYLYMLMEVCLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  297

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 298   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  357

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 358   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  417

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 418   ERLGNLKNGVKDIQKHKWF  436

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK HIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEV CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 1.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013