EKS-ICT-00327

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00327

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	394.7	1.7E-118	117	377	261

Status

Unreviewed

Ensembl Protein

ENSSTOP00000006865

UniProt Accession

I3MA72;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007672	ENSSTOP00000006865	ENSSTOT00000007676

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MLPEAGSLWL LRLLRDIQLA QFYRPILEEL NVTRPEHFDF VKPEDLDGIG MGRPAQRRLA 60

EALKRHRLGV KSKNWVYKIL GSFAPEQKET IRPSDSLTCL SEPEGRLKCL IPEDAVCRRE 120

LLGSGCFGVV YRGLWTLPSG QSIPVAVKSL RVGPEGPMGT ELGDFLREVS VMMKLEHPHV 180

LRLHGLVLGQ PLQMVMELAP LGSLHARLTE PAPTPPLPVP LLCLFLRQLA GAMAYLGARG 240

LVHRDLATRN LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRQGAF 300

SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEKDR ARLPRPPLCS RALYSLALRC 360

WAPHPADRPS FSCLEGLLQE AWPSEGRCVR SVTEPGALRM EPGDPITIIE GSFSSHTDST 420

TWKGQNGRTF KVGSFPASAV TLAELGGSPA TRPVHRGSPA RGEQHRGSID GDREKAKPRD 480

LPPAWGQRRK APLQRMKGIS KSLESVLSLG PRPTGGGSSP PELRHARAVP QGPPGLPPRL 540

PFTSNSSQPS QPPRERPPWP KREPPHNHRI GVPGASKATV SSGGLLLDPE WQRKITEMEL 600

NVHGVTHQEC QAALKATGGD VVSAIRNLKV DQLFHLSSRS RTDCWRILEH YQWDLSAASR 660

YVLARS 666

Nucleotide Sequence
(FASTA)

ATGCTTCCTG AGGCCGGTTC CCTGTGGCTA CTGCGGCTGC TCCGGGATAT CCAGCTGGCC 60

CAGTTTTATC GGCCCATCCT TGAGGAGCTT AATGTCACTC GGCCAGAGCA TTTTGACTTT 120

GTAAAGCCTG AGGACCTGGA TGGCATTGGC ATGGGCCGGC CTGCCCAGCG CAGACTGGCT 180

GAAGCTCTGA AGAGACACCG TTTGGGAGTC AAGTCTAAGA ACTGGGTTTA CAAGATTCTT 240

GGGAGTTTTG CCCCTGAGCA GAAAGAGACC ATCCGACCCT CAGATAGCCT TACATGCCTC 300

TCTGAGCCAG AAGGGAGACT CAAGTGTCTG ATCCCAGAGG ATGCTGTATG CAGAAGGGAG 360

CTGCTGGGCT CAGGCTGCTT TGGCGTGGTA TATCGAGGGC TGTGGACACT GCCCAGTGGC 420

CAGAGTATCC CAGTGGCTGT CAAGTCCCTC CGGGTAGGTC CGGAAGGTCC CATGGGCACA 480

GAGCTGGGAG ACTTCCTGCG AGAAGTATCT GTCATGATGA AATTGGAGCA CCCACATGTG 540

CTGCGTTTGC ATGGCCTTGT ACTGGGTCAG CCTCTGCAGA TGGTGATGGA GCTGGCACCA 600

TTGGGCTCCC TGCACGCGCG CCTGACTGAG CCGGCCCCAA CACCCCCGCT GCCAGTGCCC 660

CTGCTGTGTC TCTTTCTGCG GCAGTTAGCT GGGGCCATGG CGTACTTGGG AGCCCGTGGA 720

CTGGTGCACC GGGACCTTGC TACACGCAAC CTGCTGCTGG CCTCACCACG CACTATCAAG 780

GTGGCAGACT TCGGGCTGGT GCGGCCGCTG GGCGGGGCCC GGGGCCGCTA CGTCATGGGC 840

GGGCCCCGCC CTATCCCTTA TGCCTGGTGT GCCCCAGAGA GCCTGCGTCA GGGAGCCTTC 900

TCATCAGCCT CTGATGTGTG GATGTTTGGA GTGACCTTGT GGGAGATGTT CTCTGGGGGT 960

GAGGAACCCT GGGCTGGGGT TCCACCATAC CTCATCCTGC AGCGGCTGGA GAAGGACCGA 1020

GCTCGGCTTC CAAGGCCTCC CCTGTGCTCC AGGGCCCTCT ACTCCCTGGC CTTACGCTGC 1080

TGGGCCCCTC ACCCTGCGGA CCGGCCTAGC TTTTCCTGCC TGGAAGGGTT GCTGCAAGAG 1140

GCCTGGCCTT CTGAAGGACG CTGCGTGAGG AGTGTCACAG AGCCAGGAGC CCTGCGGATG 1200

GAGCCCGGTG ACCCCATTAC CATCATTGAG GGCAGCTTCT CTTCCCACAC AGATTCCACA 1260

ACCTGGAAGG GACAGAATGG ACGCACCTTT AAAGTGGGCA GTTTCCCAGC CTCAGCAGTG 1320

ACGCTGGCAG AATTGGGAGG CTCTCCAGCC ACCCGCCCAG TCCACAGAGG CTCTCCAGCC 1380

CGAGGAGAGC AACACAGGGG AAGCATAGAT GGGGACAGAG AGAAGGCAAA GCCTCGGGAT 1440

CTACCTCCAG CATGGGGCCA GAGAAGGAAG GCTCCCTTGC AGAGGATGAA AGGTATTTCC 1500

AAGAGTCTGG AGTCAGTTCT GTCCTTGGGC CCTCGCCCTA CAGGGGGTGG TTCAAGCCCC 1560

CCTGAACTTC GACATGCCAG AGCTGTGCCT CAAGGACCCC CAGGCCTGCC TCCACGCCTG 1620

CCTTTTACCT CCAACTCTTC TCAGCCCAGC CAGCCCCCTA GGGAACGGCC TCCTTGGCCC 1680

AAAAGAGAAC CCCCACACAA TCACCGCATT GGAGTGCCTG GAGCCAGTAA AGCCACTGTC 1740

TCCTCTGGAG GCCTCTTGCT TGACCCTGAG TGGCAGAGGA AGATTACAGA GATGGAGCTG 1800

AACGTGCATG GAGTCACTCA CCAGGAGTGC CAAGCAGCAC TAAAAGCCAC TGGGGGAGAT 1860

GTTGTTTCTG CCATCCGGAA CCTCAAGGTA GACCAGCTCT TCCACCTGAG TAGCCGGTCT 1920

AGAACGGACT GTTGGCGCAT CCTGGAGCAC TACCAGTGGG ACCTCTCTGC TGCCAGTCGT 1980

TATGTCCTGG CCCGGTCCTG A 2001

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkle  59

         ++ e+lG+G+fgvv rg W+ psg+s++vavk+l+  ++  ++tel+dflrevsv++kle

Q: 117   CRRELLGSGCFGVVYRGLWTLPSGQSIPVAVKSLRvgPEGPMGTELGDFLREVSVMMKLE  176

         67899*****************************9999**********************

S: 60    henlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayl  119

         h++++rl+G+vl+qpl++v+ela+lgsl++rl+++a +++l+v ll+ +++q+a ++ayl

Q: 177   HPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTEPAPTPPLPVPLLCLFLRQLAGAMAYL  236

         ************************************************************

S: 120   eskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslr  179

         +++ lvhrdla+rnlllas++++k++dfGlvr+lg ++++yv+  ++++P+aWcaPeslr

Q: 237   GARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLR  296

         ************************************************************

S: 180   trkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysl  239

         + +fssasdvW+fGvtlWemfs GeePW+g++++ il++++k+++rl++P++c++++ysl

Q: 297   QGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDRARLPRPPLCSRALYSL  356

         ************************************************************

S: 240   llkcWakkpadrpkfsalkek  260

         +l+cWa +padrp+fs l++

Q: 357   ALRCWAPHPADRPSFSCLEGL  377

         ****************99875

Domain Sequence
(FASTA)

CRRELLGSGC FGVVYRGLWT LPSGQSIPVA VKSLRVGPEG PMGTELGDFL REVSVMMKLE 60

HPHVLRLHGL VLGQPLQMVM ELAPLGSLHA RLTEPAPTPP LPVPLLCLFL RQLAGAMAYL 120

GARGLVHRDL ATRNLLLASP RTIKVADFGL VRPLGGARGR YVMGGPRPIP YAWCAPESLR 180

QGAFSSASDV WMFGVTLWEM FSGGEEPWAG VPPYLILQRL EKDRARLPRP PLCSRALYSL 240

ALRCWAPHPA DRPSFSCLEG L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013