EKS-ICT-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	300.6	1.1E-89	522	778	257

Status

Unreviewed

Ensembl Protein

ENSSTOP00000006957

UniProt Accession

I3MAE0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK3

Gene Synonyms/Alias

JAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007752	ENSSTOP00000006957	ENSSTOT00000007771

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1103

Protein Sequence
(FASTA)

MAPPSEETPL ISQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSFGDHSA EELCVRAAKA 60

SGILPVYHSL FALATEDLSC WFPPSHVFSV EDAGTQVLVY RLRFYFPNWF GLEKCHRFGL 120

RKDLASAILD LPVLEHLFAQ HRSDLLSGRL HVGLSLQEQG ECLSLAVLDV ARMACEQGQR 180

PAQLLKTVSY KACLPPGLRD LIQGLSFVTR RRIRTTVRCA LRRVAACQAD RHSLMAKYIM 240

DLERLDPSGT TETFRVGLSG AAGGQDGQGL LRVAGGSGIS WSPAAQEVFQ PFCDFPEIVD 300

ISIKQAPRVG PAGEHRLVTI TRTDNQILEA EFPGLPEALS FLALVDGYFR LICDSRHFFC 360

KEVAPPRLLE EVAEQCYGPI TLDFAINKLK AGGSLPGSYV LRRSPQDFDS FLLTVCVQTP 420

LGPDYKGCLI RRDPGGGTVS LVGLGRPHSS LRELLAACWD GGLHVDGVAL QLSSCCTPRP 480

KEKTNLTVVR RGCGPPSTSP VQPQSQHKLN QMTFHKIPAD SLEWHENLGH GSFTKIYRGC 540

RHEAVDGEAR ATEVLLKVMD AKHRNCMESF LEAASLMSQV SYPHLVLLHG VCMAGDSIMV 600

QEFVLLGAID TYLRKHGHLV PASWKLQVVK QLAYALNYLE DKGLPHGNVS ARKVLLAREG 660

ADGSSPFIKL SDPGVSPTVL SLEMLTDRIP WVAPECLQET QTLGLEADKW GFGATVWEVF 720

SGIPMPLINL DPPKKLKFYE DRQQLPAPKW TELALLIQQC MAYEPGQRPS FRAVIRDLNS 780

LITSDYELLS DPTPGTLAPR DGLWSGAQLY ACQDPTIFEE RHLKYISQLG KGNFGNVELC 840

RYDPLGDNTG ALVAVKQLQH SGPDQQRDFQ REIQILKAMH SDFIVKYRGV SYGPGRQSLR 900

LVMEYLPSGC LRDFLQRHRA RLDSSRLLLY ASQICKGMEY LGSRRCVHRD LAARNILVEN 960

EAHVKIADFG LAKLLPLDKD YYVVREPGQS PIFCAHQNLS LLISKMGIVR SPGEGGLDWA 1020

APKEPSCSPA RARFRSDGDS RGLRPCVRSP SLGTDGRRDP SVPTAEVGVH ELMKLCWALS 1080

PQDRPTFSVL GPQLDALWSG NRG 1103

Nucleotide Sequence
(FASTA)

ATGGCACCTC CAAGTGAGGA GACGCCCCTG ATCTCCCAGC GCTCCTGCAG CCTCTCCTCC 60

TCGGAGGCTG GTGCGCTCCA CGTGCTGCTG CCTCCTCGGG GTCCGGGGCC TCCACAGAGG 120

CTGTCTTTCT CCTTTGGGGA CCACTCGGCT GAGGAACTGT GTGTGAGGGC TGCCAAGGCC 180

AGCGGCATCC TGCCCGTGTA CCACTCACTC TTTGCCTTGG CCACGGAGGA CTTGTCTTGC 240

TGGTTCCCTC CGAGCCACGT CTTCTCTGTG GAAGATGCGG GCACCCAAGT CCTAGTCTAC 300

AGACTGCGCT TTTACTTTCC CAACTGGTTT GGGCTGGAGA AGTGCCACCG CTTTGGGCTA 360

CGCAAGGACT TGGCCAGTGC CATCCTGGAC CTGCCTGTCC TGGAACACCT CTTTGCCCAG 420

CACCGCAGTG ACCTGCTGAG TGGGCGCCTG CACGTGGGTC TCAGCCTCCA GGAGCAGGGC 480

GAGTGTCTCA GCCTGGCCGT GCTGGACGTG GCCCGCATGG CCTGTGAGCA GGGCCAGCGG 540

CCTGCCCAGC TCCTGAAGAC CGTCAGCTAC AAGGCCTGCC TGCCGCCTGG CCTGCGCGAC 600

CTGATCCAGG GTCTGAGCTT CGTGACCCGG AGACGTATTC GGACCACGGT GCGCTGCGCC 660

TTGCGCCGTG TGGCGGCCTG CCAGGCGGAC AGGCACTCGC TCATGGCCAA GTACATCATG 720

GACCTGGAGC GGCTGGACCC TTCTGGGACC ACTGAGACCT TCCGCGTCGG TCTGTCCGGG 780

GCCGCGGGTG GCCAGGATGG GCAGGGGTTG CTCCGCGTGG CTGGCGGCAG CGGCATCTCC 840

TGGAGTCCCG CAGCACAGGA GGTCTTCCAG CCCTTCTGTG ACTTTCCAGA AATCGTGGAC 900

ATCAGCATCA AGCAAGCCCC ACGGGTTGGC CCGGCTGGGG AGCACCGCCT GGTCACTATC 960

ACCAGGACGG ACAACCAGAT CCTGGAGGCC GAGTTCCCGG GGCTGCCCGA GGCGCTGTCC 1020

TTCTTGGCTC TGGTGGACGG TTACTTCCGC CTGATTTGTG ACTCCCGCCA CTTCTTCTGC 1080

AAGGAGGTGG CACCGCCACG GCTGCTGGAG GAAGTGGCCG AGCAGTGCTA TGGCCCCATC 1140

ACCCTGGACT TTGCCATCAA CAAGCTCAAG GCGGGGGGCT CACTTCCCGG CTCCTACGTT 1200

CTCCGTCGCA GCCCCCAGGA CTTCGACAGC TTCCTCCTCA CTGTGTGTGT GCAGACACCC 1260

CTCGGGCCCG ACTACAAGGG CTGCCTCATC CGGCGGGACC CCGGAGGAGG AACCGTGTCG 1320

CTGGTCGGCC TCGGCCGTCC TCACAGCAGC CTTCGGGAGC TGCTGGCAGC CTGCTGGGAC 1380

GGCGGGCTTC ACGTGGATGG AGTTGCCCTG CAGCTTAGCT CCTGCTGTAC CCCCAGACCC 1440

AAAGAAAAGA CCAACTTGAC TGTGGTCCGG AGGGGCTGCG GCCCACCCTC CACCTCCCCT 1500

GTCCAGCCCC AGTCCCAACA TAAGCTGAAT CAGATGACGT TCCACAAGAT CCCTGCCGAC 1560

AGCCTGGAGT GGCATGAGAA CCTGGGCCAC GGGTCCTTCA CCAAGATTTA CCGGGGATGT 1620

CGCCACGAGG CTGTGGACGG GGAGGCCCGG GCGACGGAGG TGCTCCTGAA GGTCATGGAC 1680

GCCAAGCACA GGAACTGCAT GGAGTCCTTC CTGGAAGCTG CCAGCTTGAT GAGTCAGGTG 1740

TCCTACCCGC ATCTGGTGCT GCTCCACGGC GTGTGCATGG CTGGAGACAG CATCATGGTG 1800

CAGGAATTCG TCCTCCTGGG AGCCATAGAC ACCTACCTGC GCAAGCATGG CCACCTGGTG 1860

CCAGCCAGCT GGAAGCTGCA GGTGGTCAAA CAGCTGGCCT ACGCCCTCAA CTACCTGGAG 1920

GACAAAGGCC TCCCTCATGG CAACGTCTCA GCCCGGAAGG TGCTGCTGGC TCGGGAGGGG 1980

GCTGATGGGA GCTCGCCTTT CATCAAGCTG AGCGACCCTG GTGTCAGCCC CACTGTGCTA 2040

AGCCTGGAAA TGCTCACCGA CAGGATCCCC TGGGTGGCCC CCGAGTGTCT CCAGGAGACG 2100

CAGACGCTTG GCTTGGAAGC TGACAAGTGG GGGTTTGGTG CCACAGTCTG GGAGGTGTTC 2160

AGCGGGATCC CGATGCCCCT CATCAACCTG GACCCCCCCA AGAAACTCAA GTTTTATGAG 2220

GACCGGCAGC AGCTGCCGGC CCCCAAGTGG ACAGAGCTGG CCCTGCTGAT CCAGCAGTGC 2280

ATGGCCTACG AGCCAGGCCA GAGGCCCTCC TTCCGAGCTG TCATCCGGGA CCTCAACAGC 2340

CTCATCACTT CAGACTATGA GCTCCTCTCA GACCCAACCC CTGGCACCCT GGCGCCCCGA 2400

GACGGGCTGT GGAGTGGTGC CCAGCTCTAT GCCTGCCAGG ACCCCACGAT CTTTGAGGAA 2460

AGACACCTCA AGTACATCTC ACAGCTGGGA AAGGGCAACT TTGGCAATGT GGAGTTGTGC 2520

CGCTATGACC CGCTGGGTGA CAACACGGGC GCCCTGGTGG CTGTGAAGCA GCTGCAGCAC 2580

AGTGGGCCAG ATCAGCAGAG GGACTTCCAG CGGGAGATCC AGATCCTCAA AGCCATGCAC 2640

AGTGACTTTA TTGTGAAGTA CCGTGGTGTC AGCTATGGCC CCGGTCGCCA GAGCTTGCGG 2700

CTGGTCATGG AGTACCTGCC CAGCGGATGC CTGCGTGACT TTCTGCAGCG GCACCGCGCA 2760

CGCCTGGACT CGAGCCGCCT CCTCCTCTAC GCCTCGCAGA TCTGCAAGGG CATGGAGTAC 2820

CTGGGCTCCC GCCGCTGCGT GCATCGCGAC CTGGCGGCCC GGAACATCCT GGTGGAGAAC 2880

GAGGCTCACG TCAAGATCGC CGACTTCGGC TTGGCCAAGC TGCTGCCGCT CGACAAGGAC 2940

TACTACGTGG TTCGCGAGCC CGGCCAGAGC CCCATCTTTT GCGCTCATCA GAACCTCAGT 3000

TTGCTCATTT CCAAAATGGG GATAGTAAGG TCTCCTGGGG AGGGAGGATT AGACTGGGCA 3060

GCGCCTAAAG AGCCCAGCTG CAGCCCTGCC CGTGCGCGCT TCAGAAGTGA TGGTGATTCT 3120

CGCGGCTTAC GACCTTGTGT GAGAAGCCCA TCCCTGGGTA CAGATGGGAG AAGGGATCCC 3180

AGTGTACCTA CAGCAGAGGT AGGAGTTCAT GAACTTATGA AGCTGTGCTG GGCCTTGAGC 3240

CCACAGGACC GGCCGACCTT CAGTGTCCTG GGTCCGCAGC TGGACGCGCT GTGGAGTGGA 3300

AACCGGGGGT AG 3312

Domain Profile

S: 1     lkqiesLgkgtftkvfevred..aegdsteeevalkvLkesgedisrdfkreaeilsqls  58

         l+++e+Lg+g+ftk+++++++   +g+++ +ev+lkv++ ++++++++f ++a+++sq+s

Q: 522   LEWHENLGHGSFTKIYRGCRHeaVDGEARATEVLLKVMDAKHRNCMESFLEAASLMSQVS  581

         689****************98789************************************

S: 59    hehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         ++h+v l+gvc+a+++ ++V+e+v  G++d+yLrk+ + +++s++l+v+kqla+a++YLe

Q: 582   YPHLVLLHGVCMAGDS-IMVQEFVLLGAIDTYLRKHGHLVPASWKLQVVKQLAYALNYLE  640

         ***************9.7******************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqdeYylvreerdsripwlap  178

         dk l h++v+ar+vL++re+ +g++pf+klsdpg++ +v      l+ e+ ++ripw+ap

Q: 641   DKGLPHGNVSARKVLLAREGADGSSPFIKLSDPGVSPTV------LSLEMLTDRIPWVAP  694

         ***************************************......***************

S: 179   eclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpkcpa  238

         ecl+e ++l +++d+W+Fg+t++e+  +s   +pl + ++ +kl+++e++++lp+pk++

Q: 695   ECLQETQTLGLEADKWGFGATVWEV--FSGIPMPLINLDPPKKLKFYEDRQQLPAPKWT-  751

         *************************..99******************************.

S: 239   elaelmtnclsyepsqrpsFrailedl  265

         ela l+++c++yep qrpsFra+++dl

Q: 752   ELALLIQQCMAYEPGQRPSFRAVIRDL  778

         *************************98

Domain Sequence
(FASTA)

LEWHENLGHG SFTKIYRGCR HEAVDGEARA TEVLLKVMDA KHRNCMESFL EAASLMSQVS 60

YPHLVLLHGV CMAGDSIMVQ EFVLLGAIDT YLRKHGHLVP ASWKLQVVKQ LAYALNYLED 120

KGLPHGNVSA RKVLLAREGA DGSSPFIKLS DPGVSPTVLS LEMLTDRIPW VAPECLQETQ 180

TLGLEADKWG FGATVWEVFS GIPMPLINLD PPKKLKFYED RQQLPAPKWT ELALLIQQCM 240

AYEPGQRPSF RAVIRDL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775	; Tyr_kinase_non-rcpt_Jak3.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01826	; JANUSKINASE3.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013