EKS-ICT-00355

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00355

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	379.4	7.2E-114	191	439	249

Status

Unreviewed

Ensembl Protein

ENSSTOP00000006996

UniProt Accession

I3MAH2;

Protein Name

Protein Synonyms/Alias

Gene Name

PTK6

Gene Synonyms/Alias

PTK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007821	ENSSTOP00000006996	ENSSTOT00000007817

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

448

Protein Sequence
(FASTA)

MVSRDQVHLG PKYVGLWDFE ARTDEELSFR QGDIFHVTRK EEQWWWATLL DSAGAALAEG 60

YVPCNYLAEE EAGESEPWFF GQISRSEAVH QLQAEGNPTG AFLIRVSGKL GADYVLSVRD 120

AQVVRHYRIW RRSGRLHLNE VVSFLSLPEL LDYHKAQSLS HGLRLTVPCC KHESEPLPHW 180

ANWERPREEF TLCRKLGAGY FGEVFEGLWK DQVRVAIKVI SRDNLLHQNT FQREIQAMKQ 240

LRHRHILALY AVASLGDPVY IITELMPKGS LLQLLRDSDK QALPISELVD LASQVAEGMC 300

YLESQNYVHR DLAARNILVG ENNICKVGDF GLARLIKEDI YLSHDHSIPY KWTAPEALSL 360

GYYSIRSDVW SFGVLLHEIF SRGQTPYPGM SNHEAFLRVD AGYRMPCPLE CPPPVYGLMC 420

SCWSRDPEQR PCFQALWERL SGFTRYEN 448

Nucleotide Sequence
(FASTA)

ATGGTGTCCC GGGACCAGGT CCACCTAGGC CCCAAGTATG TGGGCCTCTG GGACTTTGAG 60

GCACGGACAG ATGAGGAGCT GAGCTTCCGG CAGGGGGACA TCTTCCACGT GACCAGGAAG 120

GAGGAGCAGT GGTGGTGGGC CACCCTGCTG GACTCTGCAG GTGCGGCCCT TGCTGAGGGC 180

TATGTGCCCT GCAACTACCT GGCAGAGGAG GAGGCCGGGG AGTCCGAGCC GTGGTTCTTT 240

GGCCAAATCT CCCGCTCAGA GGCCGTGCAC CAGCTACAGG CGGAGGGCAA CCCCACTGGT 300

GCCTTCCTGA TCCGGGTCAG CGGGAAGCTG GGAGCAGACT ACGTTCTCTC TGTGCGGGAT 360

GCTCAGGTCG TGCGGCACTA CAGGATCTGG CGGCGCTCTG GCCGGCTACA CTTGAACGAG 420

GTAGTGTCCT TTCTCAGTCT GCCTGAGCTC CTGGACTACC ACAAGGCCCA GAGCCTGTCC 480

CATGGCCTGC GGCTGACCGT GCCCTGCTGT AAGCATGAGT CGGAGCCCCT GCCCCACTGG 540

GCCAACTGGG AGAGGCCACG GGAGGAGTTC ACGCTCTGCC GGAAGCTGGG CGCTGGCTAT 600

TTTGGGGAGG TCTTTGAAGG GCTCTGGAAA GACCAGGTCC GAGTGGCCAT CAAGGTGATT 660

TCCCGAGACA ACCTCCTGCA CCAGAACACC TTCCAGCGGG AGATCCAGGC CATGAAGCAG 720

CTGCGGCACA GGCACATCCT GGCGCTGTAC GCCGTGGCGT CCCTAGGGGA CCCCGTCTAC 780

ATCATCACGG AGCTCATGCC CAAGGGGAGC CTGCTGCAGC TGCTGCGGGA CTCTGATAAG 840

CAAGCCCTGC CCATCTCGGA GCTGGTGGAC CTTGCATCGC AGGTGGCAGA GGGCATGTGC 900

TACTTGGAGT CACAGAACTA TGTTCATCGG GACCTGGCTG CCAGGAACAT CCTCGTGGGG 960

GAGAACAATA TCTGCAAAGT GGGGGATTTT GGGCTGGCCA GGCTCATCAA GGAGGACATC 1020

TACCTCTCCC ATGACCACAG CATCCCCTAC AAGTGGACAG CCCCTGAGGC ACTCTCCCTA 1080

GGGTATTATT CCATCAGATC TGATGTCTGG TCCTTCGGGG TCCTCCTCCA CGAGATCTTC 1140

AGCAGGGGTC AGACACCTTA CCCAGGCATG TCCAACCACG AAGCCTTCCT GAGGGTGGAC 1200

GCTGGCTACC GCATGCCTTG CCCCCTGGAG TGCCCACCTC CCGTGTACGG GCTGATGTGC 1260

TCCTGCTGGA GCAGGGACCC AGAGCAGAGG CCTTGCTTCC AAGCCCTGTG GGAGAGACTC 1320

TCTGGCTTCA CCAGGTACGA GAAC 1344

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60

         +l++klG+G+fGev++g+wk++v+va+k++++++ l++++f++e+q++k+lrh+++++ly

Q: 191   TLCRKLGAGYFGEVFEGLWKDQVRVAIKVISRDNlLHQNTFQREIQAMKQLRHRHILALY  250

         799******************************9899***********************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av+s ++P+yi+telm kGsll++l+++++++l++++lvdla+qvaeGm+yle++n++hr

Q: 251   AVASLGDPVYIITELMPKGSLLQLLRDSDKQALPISELVDLASQVAEGMCYLESQNYVHR  310

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dlaarn+lvge++++kv+dfGlarli++d+y +++ + +P+kWtaPea++lg ++i+sdv

Q: 311   DLAARNILVGENNICKVGDFGLARLIKEDIYLSHD-HSIPYKWTAPEALSLGYYSIRSDV  369

         *******************************9876.99**********************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+ei+++G++PypGm+n+e++ +v++gyr+p+p ecp  +y l+++cw++dpe+

Q: 370   WSFGVLLHEIFSRGQTPYPGMSNHEAFLRVDAGYRMPCPLECPPPVYGLMCSCWSRDPEQ  429

         ************************************************************

S: 241   rPtfetlqev  250

         rP+f++l e

Q: 430   RPCFQALWER  439

         *****99765

Domain Sequence
(FASTA)

TLCRKLGAGY FGEVFEGLWK DQVRVAIKVI SRDNLLHQNT FQREIQAMKQ LRHRHILALY 60

AVASLGDPVY IITELMPKGS LLQLLRDSDK QALPISELVD LASQVAEGMC YLESQNYVHR 120

DLAARNILVG ENNICKVGDF GLARLIKEDI YLSHDHSIPY KWTAPEALSL GYYSIRSDVW 180

SFGVLLHEIF SRGQTPYPGM SNHEAFLRVD AGYRMPCPLE CPPPVYGLMC SCWSRDPEQR 240

PCFQALWER 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013