EKS-ICT-00354

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00354

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	390.1	3.9E-117	214	458	245

Status

Unreviewed

Ensembl Protein

ENSSTOP00000007008

UniProt Accession

I3MAI3;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007835	ENSSTOP00000007008	ENSSTOT00000007831

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

458

Protein Sequence
(FASTA)

PAQRPSPRPA QRPSPPPAQR PSPRQSPELR SAPPAQLFHA LYDFTARRPE ELSVTRGDRL 60

YALKEEGDYI FARRLSSPPS TGLVPINYVA KATPEMLSDQ PWYFCEINRT QAQQLLLSPA 120

NAPGAFLIRP SESSLGDYSL SVRAQAKVCH YRISTAPGGS LYLQEGRLFP SLQSLLAYYK 180

ANWKLIQNPL LQPCVPQRPP AQDKWERPRS EFVLGKKLGE GYFGQVWEGL WQGSVPVAVK 240

TIKSANMKMA DLAKEIEVLK TLRHERLIRL YAVCSDGEPV YIVTELMCKG SLQSYLGSPE 300

GQALSLPLLL SFTCQVAEGM GYLEEQRVVH RDLAARNVLV GNDLTCKVAD FGLARLLKDD 360

IYSPSSGFKI PVKWTAPEAA NYRVFTQKSD IWSFGILLYE IFTFGQCPYE GMSNQETLRR 420

ISRGYRLPCP AACPAEVYTL MLRCWKDSPE ERPTFAML 458

Nucleotide Sequence
(FASTA)

CCAGCTCAGC GACCGAGCCC CCGGCCAGCC CAGCGCCCTA GCCCACCGCC GGCTCAGCGA 60

CCGAGTCCCC GGCAGAGCCC TGAGTTGCGC TCTGCGCCCC CCGCGCAGCT CTTTCATGCG 120

CTCTACGACT TCACCGCGCG GCGCCCGGAG GAGCTGAGCG TCACTCGCGG GGACAGGCTC 180

TACGCCCTTA AGGAGGAGGG CGACTATATC TTCGCCCGAA GGCTCTCCAG CCCGCCCAGC 240

ACCGGGCTGG TGCCCATCAA CTACGTGGCC AAAGCCACCC CTGAGATGCT CTCAGACCAA 300

CCCTGGTACT TCTGCGAGAT CAACAGGACC CAGGCCCAGC AACTGCTCTT GTCCCCTGCT 360

AACGCCCCAG GGGCCTTCCT CATCCGGCCC AGTGAGAGCA GCCTTGGAGA CTACTCACTG 420

TCAGTCCGGG CCCAGGCCAA AGTCTGCCAC TACCGCATCA GTACAGCCCC GGGAGGCAGC 480

CTCTACCTGC AGGAGGGCCG GCTCTTCCCC AGCCTGCAGT CTCTGCTTGC CTACTACAAG 540

GCCAACTGGA AGCTGATCCA GAACCCACTG CTGCAGCCCT GCGTGCCCCA GAGGCCCCCA 600

GCACAGGACA AGTGGGAGCG ACCTCGCTCA GAATTTGTCC TTGGGAAGAA GCTGGGTGAA 660

GGCTACTTCG GGCAAGTGTG GGAAGGCCTG TGGCAGGGCT CTGTGCCCGT GGCAGTCAAG 720

ACCATTAAGT CAGCCAACAT GAAGATGGCT GACCTGGCCA AGGAGATCGA GGTGCTGAAG 780

ACCCTGAGGC ACGAGCGGCT CATCCGGCTG TATGCGGTGT GCTCGGATGG AGAGCCTGTG 840

TACATTGTCA CGGAGCTCAT GTGCAAGGGC AGTCTGCAGT CCTATCTGGG CAGCCCCGAG 900

GGCCAGGCCC TGAGCCTGCC GCTCTTGCTG AGCTTCACCT GCCAGGTGGC CGAGGGCATG 960

GGCTACCTGG AGGAGCAGCG TGTGGTCCAC CGGGACCTGG CTGCCAGGAA CGTGCTCGTG 1020

GGCAATGACC TCACTTGCAA GGTGGCCGAC TTTGGCCTGG CCCGGCTGCT CAAGGATGAT 1080

ATCTACTCCC CAAGCAGTGG CTTCAAGATC CCTGTCAAAT GGACGGCACC TGAGGCCGCC 1140

AACTACCGTG TCTTCACCCA GAAGTCAGAC ATCTGGTCCT TTGGCATCTT GCTCTACGAG 1200

ATCTTCACCT TCGGCCAGTG TCCCTATGAA GGAATGTCTA ACCAGGAGAC ACTGCGGCGG 1260

ATCAGCCGAG GATACCGGCT GCCGTGCCCA GCCGCCTGCC CAGCGGAGGT CTACACACTC 1320

ATGTTGAGGT GCTGGAAGGA CAGCCCTGAG GAGCGGCCCA CTTTTGCCAT GCTG 1374

Domain Profile

S: 3     lvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklyav  62

         l kklGeG+fG+vw+g+w+gsv+vavkt+k+++++ +++ +e+++lk+lrhe+l++lyav

Q: 214   LGKKLGEGYFGQVWEGLWQGSVPVAVKTIKSANMKMADLAKEIEVLKTLRHERLIRLYAV  273

         789*********************************************************

S: 63    vseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrdl  122

         +s +eP+yivtelm kGsl+++l + eg++l+lp l+ +++qvaeGm ylee++++hrdl

Q: 274   CSDGEPVYIVTELMCKGSLQSYLGSPEGQALSLPLLLSFTCQVAEGMGYLEEQRVVHRDL  333

         ************************************************************

S: 123   aarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvWs  182

         aarnvlvg++l++kvadfGlarl++dd+y++++g k+P+kWtaPea+++++ft+ksd+Ws

Q: 334   AARNVLVGNDLTCKVADFGLARLLKDDIYSPSSGFKIPVKWTAPEAANYRVFTQKSDIWS  393

         ************************************************************

S: 183   fGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeerP  242

         fGill+ei+t G++Py+Gm+n+e+l++++rgyrlp+p++cp+e+y+l+l+cwk +peerP

Q: 394   FGILLYEIFTFGQCPYEGMSNQETLRRISRGYRLPCPAACPAEVYTLMLRCWKDSPEERP  453

         ************************************************************

S: 243   tfetl  247

         tf +l

Q: 454   TFAML  458

         **976

Domain Sequence
(FASTA)

LGKKLGEGYF GQVWEGLWQG SVPVAVKTIK SANMKMADLA KEIEVLKTLR HERLIRLYAV 60

CSDGEPVYIV TELMCKGSLQ SYLGSPEGQA LSLPLLLSFT CQVAEGMGYL EEQRVVHRDL 120

AARNVLVGND LTCKVADFGL ARLLKDDIYS PSSGFKIPVK WTAPEAANYR VFTQKSDIWS 180

FGILLYEIFT FGQCPYEGMS NQETLRRISR GYRLPCPAAC PAEVYTLMLR CWKDSPEERP 240

TFAML 245

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013