EKS-ICT-00391

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00391

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Trk	534.7	3.7E-161	513	782	270

Status

Unreviewed

Ensembl Protein

ENSSTOP00000007027

UniProt Accession

I3MAJ9;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

NTRK1

Gene Synonyms/Alias

NTRK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007842	ENSSTOP00000007027	ENSSTOT00000007853

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

799

Protein Sequence
(FASTA)

MLRGGPRGQL GWHRQATGPG SLLAWLMLAS AGAASCPDVC CRFGPSGLRC SKAGTLYSLR 60

QLPTAENLTE LYVENQQHLH SLELGDLQGL GQLRNLTIVK SGLRFVAPDA FHLTPRLSRL 120

NLSFNALESL SWKTLQGLSL QELVLSGNPL RCSCGLHWLQ RWEEEGLGGL RAQRLQCSGP 180

RGQPLALGHN TSCGVPTLKV QMPNASVEVG DDVLLQCHVE GQGLQQAGWI LTELEGSATV 240

TKSGDLPSLG LTLANVTSDL NRKNVTCWAE NDVGRAEVSV QVNVSFPASV QLATAVEMHH 300

WCIPFSVDGQ PAPSLRWLFN GSVLNETSFI FTEFLEPALA NETVRHGCLR LNQPTHVNNG 360

NYTLLATNPY GQAADYVMAA FMDNPFEFNP EDPIPVSFSP VDTNSTSKDP VEKKDETPFG 420

VSVAVGLAVF ACLFLSALLL VLNKCGQRNK FGINRPAVLA PEDGLAMSLH FMTLSGSSLS 480

PTDGKGSGLQ GHVIENPQYF SDACVHHIKR RDIVLKWELG EGAFGKVFLA ECHGLLPEQD 540

KMLVAVKALK EVSESARQDF QREAELLTML QHQHIVRFFG VCTEGRPLLM VFEYMRHGDL 600

NRFLRSHGPD AKLLAGGEDV APGPLGLGQL LAIASQVAAG MVYLASLHFV HRDLATRNCL 660

VGQGLVVKIG DFGMSRDIYS TDYYRVGGRT MLPIRWMPPE SILYRKFTTE SDVWSFGVVL 720

WEIFTYGKQP WYQLSNTEAI ECITQGRELE RPRACPPEVY AIMRGCWQRE PQHRHSIKDV 780

HARLQALAQA PPVYLDVLG 799

Nucleotide Sequence
(FASTA)

ATGCTGCGGG GCGGACCGCG CGGGCAGCTG GGCTGGCACC GCCAGGCTAC GGGCCCGGGC 60

AGCCTGCTGG CTTGGCTGAT GCTGGCCTCC GCGGGCGCTG CCTCTTGCCC CGATGTCTGC 120

TGCCGCTTTG GCCCCTCGGG GCTGCGTTGT TCCAAGGCTG GGACCCTCTA TAGCCTCCGC 180

CAACTGCCGA CCGCCGAGAA CCTGACAGAG CTCTATGTGG AGAATCAGCA GCATCTACAC 240

AGCCTGGAGC TCGGTGACCT GCAGGGCCTG GGGCAGCTGC GCAACCTCAC CATCGTGAAG 300

AGTGGCCTCC GTTTTGTGGC GCCAGATGCC TTCCATCTGA CTCCTCGGCT CAGTCGCCTG 360

AATCTCTCCT TCAACGCCCT GGAGTCTCTG TCCTGGAAGA CCCTGCAGGG CCTGTCCTTA 420

CAGGAACTGG TTCTGTCGGG AAACCCTCTG CGCTGTTCCT GTGGCTTGCA CTGGCTGCAG 480

CGCTGGGAGG AGGAGGGGCT GGGCGGCCTG CGCGCTCAGA GGCTGCAGTG CTCTGGCCCC 540

CGGGGGCAGC CCCTGGCCCT CGGCCACAAC ACCAGCTGCG GGGTGCCCAC GCTCAAGGTC 600

CAGATGCCCA ATGCCTCGGT GGAAGTCGGG GACGATGTGT TGCTGCAGTG CCACGTGGAG 660

GGACAGGGCC TTCAGCAGGC TGGCTGGATC CTCACGGAGC TGGAGGGGTC AGCCACGGTG 720

ACGAAATCTG GGGATCTGCC ATCCCTGGGG CTGACCCTCG CCAATGTCAC CAGTGACCTG 780

AACAGGAAGA ATGTGACGTG TTGGGCAGAG AATGATGTGG GCCGGGCTGA GGTCTCTGTC 840

CAGGTCAACG TCTCCTTCCC GGCCAGTGTG CAGCTGGCCA CCGCGGTGGA GATGCACCAC 900

TGGTGCATCC CCTTCTCGGT GGACGGGCAG CCCGCGCCGT CCCTGCGCTG GCTCTTCAAT 960

GGCTCCGTGC TCAACGAGAC CAGCTTCATC TTCACCGAGT TCCTGGAGCC CGCCCTGGCC 1020

AACGAGACCG TGCGGCACGG CTGCCTGCGC CTCAACCAGC CCACCCACGT CAACAACGGC 1080

AACTACACGC TGCTGGCCAC CAATCCCTAC GGCCAGGCCG CCGACTACGT CATGGCTGCC 1140

TTCATGGACA ACCCTTTCGA GTTCAACCCC GAGGACCCCA TCCCTGTCTC CTTCTCCCCA 1200

GTGGACACTA ACAGCACCTC CAAGGACCCA GTGGAGAAGA AGGATGAAAC ACCTTTTGGG 1260

GTCTCGGTGG CCGTGGGCCT GGCCGTCTTC GCCTGCCTCT TCCTTTCCGC GCTGCTCCTC 1320

GTGCTCAACA AATGCGGACA GAGAAACAAG TTTGGGATCA ACCGCCCTGC GGTGCTGGCT 1380

CCAGAGGATG GGCTGGCCAT GTCTCTGCAT TTCATGACAC TCAGTGGCAG CTCTCTGTCC 1440

CCTACTGATG GCAAAGGCTC CGGGCTCCAG GGCCACGTCA TTGAGAATCC ACAATACTTC 1500

AGTGATGCTT GTGTCCACCA CATCAAGCGC CGGGACATCG TGCTCAAGTG GGAGCTGGGC 1560

GAGGGTGCCT TTGGGAAGGT CTTCCTGGCC GAGTGCCACG GCCTGCTGCC CGAGCAGGAC 1620

AAGATGCTGG TGGCTGTCAA GGCGCTGAAG GAGGTGTCCG AGAGTGCCCG GCAGGACTTC 1680

CAGCGCGAGG CGGAGCTGCT GACCATGCTG CAGCACCAGC ACATCGTGCG CTTCTTCGGG 1740

GTCTGCACCG AGGGCCGGCC CCTGCTCATG GTCTTCGAGT ACATGCGGCA CGGGGACCTC 1800

AACCGCTTCC TCCGGTCCCA CGGGCCTGAT GCCAAGCTGC TTGCTGGCGG CGAGGACGTG 1860

GCTCCAGGTC CCCTGGGCCT TGGGCAGCTG CTGGCCATCG CTAGCCAGGT GGCCGCAGGG 1920

ATGGTGTACC TGGCCAGTTT GCATTTCGTG CACCGGGACC TGGCCACGCG CAACTGCCTG 1980

GTGGGTCAGG GCCTGGTGGT CAAGATCGGG GACTTCGGCA TGAGCAGGGA CATCTACAGC 2040

ACGGATTATT ACCGAGTGGG AGGCCGCACC ATGCTGCCCA TCCGCTGGAT GCCGCCCGAG 2100

AGCATCCTCT ACCGCAAGTT CACTACCGAG AGCGACGTGT GGAGCTTCGG GGTGGTCCTC 2160

TGGGAGATCT TCACCTACGG CAAGCAGCCC TGGTACCAGC TGTCCAACAC CGAGGCGATC 2220

GAGTGCATCA CGCAGGGCCG GGAGCTGGAG CGGCCGCGAG CCTGTCCCCC TGAGGTCTAT 2280

GCCATCATGC GGGGCTGCTG GCAGCGGGAG CCCCAGCACC GCCACAGCAT CAAGGACGTG 2340

CACGCCCGGC TGCAAGCCCT GGCCCAGGCG CCACCTGTCT ACCTGGACGT CCTGGGCTAG 2400

Domain Profile

S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60

         ivlk+elgegafgkvflaec+ llpe+dk+lvavkalk+ se+ar+df+reaellt+lqh

Q: 513   IVLKWELGEGAFGKVFLAECHGLLPEQDKMLVAVKALKEVSESARQDFQREAELLTMLQH  572

         89**********************************************************

S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118

         +hiv+++Gvcteg+pll+vfeym+hGdln+flr+hgpdakll++ge+  +g+lgl+qlla

Q: 573   QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDvaPGPLGLGQLLA  632

         ***********************************************999**********

S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178

         ia+q+aaG+vylas+hfvhrdlatrnclvg++l+vkigdfgmsrd+ystdyyrvggrtml

Q: 633   IASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML  692

         ************************************************************

S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238

         pirw+ppesilyrkfttesdvws+Gvvlwei+tyGkqp+yqlsnte+iecitqGr+lerp

Q: 693   PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERP  752

         ************************************************************

S: 239   racpkevydlmlgcwqrepqkrlnikeiya  268

         racp+evy++m+gcwqrepq+r++ik+++a

Q: 753   RACPPEVYAIMRGCWQREPQHRHSIKDVHA  782

         ****************************97

Domain Sequence
(FASTA)

IVLKWELGEG AFGKVFLAEC HGLLPEQDKM LVAVKALKEV SESARQDFQR EAELLTMLQH 60

QHIVRFFGVC TEGRPLLMVF EYMRHGDLNR FLRSHGPDAK LLAGGEDVAP GPLGLGQLLA 120

IASQVAAGMV YLASLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML 180

PIRWMPPESI LYRKFTTESD VWSFGVVLWE IFTYGKQPWY QLSNTEAIEC ITQGRELERP 240

RACPPEVYAI MRGCWQREPQ HRHSIKDVHA 270

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005030	; F:neurotrophin receptor activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000483	; Cys-rich_flank_reg_C.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR020461	; Tyr_kinase_neurotrophic_rcpt_1.
IPR020777	; Tyr_kinase_NGF_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00082	; LRRCT; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR01939	; NTKRECEPTOR.
PR01940	; NTKRECEPTOR1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013