EKS-ICT-00250

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00250

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	473.1	4.3E-142	222	535	314

Status

Unreviewed

Ensembl Protein

ENSSTOP00000007103

UniProt Accession

I3MAP7;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000007947	ENSSTOP00000007103	ENSSTOT00000007936

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

601

Protein Sequence
(FASTA)

MLTRKPSAAA PAAYPTGRGG DSAVRQLQAS PGPGAGAPRS GVGTGPPSPI ALPPLRASNA 60

AAAAHTIGGS KHTMNDHLHV SSHSHGQIQV QQLFEDNSNK RTVLTTQPNG LTTMGKTGLP 120

VVPERQLENI HRRQGSSTSL KSMEGMGKVK ATPMTPEQAM KQYMQKLTAF EHHEIFSYPE 180

IYFLGPNAKK RQGMTGGPNN GGYDDDQGSY VQVPHDHVAY RYEVLKVIGK GSFGQVVKAY 240

DHKVHQHVAL KMVRNEKRFH RQAAEEIRIL EHLRKQDKDN TMNVIHMLEN FTFRNHICMT 300

FELLSMNLYE LIKKNKFQGF SLPLVRKFAH SILQCLDALH KNRIIHCDLK PENILLKQQG 360

RSSIKVIDFG SSCYEHQRVY TYIQSRFYRA PEVILGARYG MPIDMWSLGC ILAELLTGYP 420

LLPGEDEGDQ LACMIELLGM PSQKLLDASK RAKNFVSSKG YPRYCTVTTL SDGSVVLNGG 480

RSRRGKLRGP PESREWGNAL KGCDDPLFLD FLKQCLEWDP AVRMTPGQAL RHPWLRRRLP 540

KPPTGEKTSV KRISESTGAI TSISKLPPPS SSASKLRTNL AQMTDANGNI QQRTVLPKLV 600

S 601

Nucleotide Sequence
(FASTA)

ATGTTAACCA GGAAACCTTC GGCCGCCGCT CCCGCCGCCT ACCCGACCGG CCGAGGAGGG 60

GACAGCGCTG TTCGCCAGCT TCAGGCTTCC CCGGGGCCCG GTGCGGGGGC CCCTCGGAGC 120

GGAGTGGGGA CCGGCCCGCC CTCCCCCATC GCCCTGCCTC CTCTCCGGGC CAGCAACGCT 180

GCCGCCGCAG CCCACACGAT TGGTGGCAGT AAGCACACAA TGAATGATCA CCTGCATGTT 240

AGCAGCCACA GCCACGGACA GATTCAGGTT CAGCAGCTGT TTGAGGATAA CAGTAACAAG 300

CGGACAGTGC TCACAACACA ACCAAATGGG CTTACAACAA TGGGCAAAAC CGGCTTGCCA 360

GTGGTGCCTG AGCGGCAGCT GGAGAACATT CACAGACGGC AGGGGAGCTC CACCTCTCTG 420

AAGTCTATGG AAGGCATGGG GAAAGTAAAA GCCACGCCCA TGACTCCTGA ACAAGCAATG 480

AAGCAATACA TGCAAAAATT AACAGCCTTT GAACACCATG AGATTTTTAG CTACCCTGAA 540

ATATACTTCT TGGGTCCAAA TGCAAAGAAG CGCCAGGGTA TGACAGGTGG ACCCAACAAT 600

GGTGGCTATG ATGATGATCA GGGATCATAT GTGCAGGTGC CCCACGATCA TGTGGCTTAC 660

AGGTACGAGG TCCTCAAGGT CATTGGAAAG GGGAGCTTTG GTCAAGTGGT CAAGGCCTAT 720

GATCACAAAG TCCACCAGCA TGTGGCCCTG AAGATGGTGC GGAATGAGAA GCGCTTTCAC 780

CGACAGGCTG CAGAGGAGAT CCGAATCCTG GAACACCTGC GGAAACAGGA CAAGGATAAT 840

ACCATGAACG TCATACACAT GTTGGAGAAT TTTACCTTCC GCAACCACAT CTGCATGACA 900

TTTGAACTGC TGAGTATGAA CCTCTATGAG CTCATCAAGA AGAATAAATT CCAGGGCTTT 960

AGCCTGCCTT TGGTCCGCAA ATTTGCCCAC TCGATTCTGC AGTGCTTGGA TGCTTTGCAC 1020

AAAAACAGAA TAATTCACTG TGACCTTAAG CCCGAGAATA TTTTGTTAAA GCAGCAGGGT 1080

AGAAGCAGTA TTAAAGTGAT TGATTTCGGC TCCAGTTGTT ATGAGCATCA GCGTGTCTAC 1140

ACATATATCC AGTCACGTTT TTACCGGGCT CCAGAAGTGA TACTTGGGGC CAGGTACGGC 1200

ATGCCCATTG ATATGTGGAG CCTGGGCTGC ATTTTAGCAG AGCTCCTGAC AGGTTACCCC 1260

CTCCTGCCTG GGGAGGATGA AGGGGACCAG CTGGCCTGTA TGATTGAACT GTTGGGCATG 1320

CCTTCCCAGA AACTGTTGGA TGCATCCAAA CGAGCCAAAA ATTTTGTGAG CTCCAAGGGT 1380

TATCCCCGTT ACTGCACTGT CACGACTCTT TCAGATGGTT CTGTGGTCCT CAATGGAGGC 1440

CGTTCCCGGA GAGGGAAACT GAGGGGCCCA CCAGAGAGCC GAGAGTGGGG AAATGCACTG 1500

AAGGGATGTG ATGATCCCCT TTTCCTTGAC TTCTTAAAAC AGTGTTTAGA ATGGGATCCT 1560

GCAGTTCGCA TGACCCCAGG CCAGGCTTTA CGGCACCCCT GGCTAAGGAG GCGGTTGCCA 1620

AAGCCTCCCA CTGGGGAGAA GACTTCAGTG AAAAGGATAA GCGAGAGCAC TGGTGCTATC 1680

ACGTCCATTT CCAAGTTACC TCCACCTTCC AGCTCAGCTT CTAAACTGAG GACTAATTTG 1740

GCACAAATGA CAGATGCCAA TGGGAATATT CAGCAGAGGA CAGTGTTGCC AAAACTCGTT 1800

AGCTGA 1806

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 222   YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT  281

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 282   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK  341

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs++kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 342   NRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  400

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 401   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKG  460

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d lf d+lk++le+dp

Q: 461   YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDP  520

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp +al+hp++

Q: 521   AVRMTPGQALRHPWL  535

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKVHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDNT 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SSIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDASKR AKNFVSSKGY 240

PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGNALK GCDDPLFLDF LKQCLEWDPA 300

VRMTPGQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013