EKS-ICT-00291

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00291

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	514.8	4.6E-155	498	767	270

Status

Unreviewed

Ensembl Protein

ENSSTOP00000007522

UniProt Accession

I3MBK0;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

LTK

Gene Synonyms/Alias

LTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000008387	ENSSTOP00000007522	ENSSTOT00000008393

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

852

Protein Sequence
(FASTA)

SGAILCCSAG SQAPFLPSSP LPRPIPSPWD SKVAAPPNRL EPDSPTNSPG IEGPWLFSTC 60

GASGRWGPTQ TQCDWAYEGT SVMVTVGAEG PLKGVQLWRA PGTGQYLISA YGAAGGKGAK 120

NHLSRAHGVF VSGIFSLGRG EQLYILVGQQ GEDACPGGSP ESQLVCLGES QSTEEHTAAA 180

DETERVRGSQ HWAGGGGGGG GATYVFRVRA AGPIATRRRA GAAAGGCLRR QDRARTQAAP 240

EKLENRSAAP GSGGRGGAAG GGGGWTSQAR SPQFGRSLKE GAEGGQGCAE ARATLGWAAV 300

GGFGGGGGAC TAGGGGGGYR GGDASETDIF WADGEDGVSF IHPSSELYLQ PLAVIENHGE 360

VEIRRHHNCS HCSLKDCQWQ AELHLTECMC PEGMELAVDN ITCRDLPTPS SPLVLMVAVV 420

VTLILSLLMV CGVLILVNQK KWQGLWGSRR PDPELELSKL RTSAIRTAPN PYYCQVGLGL 480

TQSWPLPPGL TEVSPANVTL LRALGHGAFG EVYEGLVIGL PGDSSPLQVA IKTLPDLCSH 540

QDELDFLMEA LIISKFSHQN IVRCVGLSLR AVPRLILLEL MSGGDMKSFL RQSRPNLGQP 600

SPLAMQDLLQ LAQDIAQGCH YLEENRFIHR DIAARNCLLS CTGPSRVAKI GDFGMARDIY 660

RANYYRKAGQ ALLPVKWMPP EALLEGIFTS KTDSWSFGVL LWEIFSLGYM PYPGHTNQEV 720

LDFIIAGSRM DPPQGCPGPV YRIMTQCWQH QPELRPNFAS ILERLQYCTQ DPDVLNSPLP 780

IELKPTLEDE GASDLGNRSL EGLRSPQPQD LSPENLKNWG RRPLVPHLSS GLKPLKSRGL 840

QPQNLWNPTY GS 852

Nucleotide Sequence
(FASTA)

TCAGGCGCCA TTCTCTGCTG CAGCGCCGGG TCCCAGGCGC CTTTTCTTCC ATCCTCGCCC 60

TTGCCGCGAC CAATTCCAAG CCCCTGGGAC TCGAAGGTGG CCGCCCCGCC TAACAGATTA 120

GAGCCAGATT CCCCCACAAA TTCTCCAGGC ATCGAAGGTC CTTGGCTGTT CTCCACCTGC 180

GGGGCCAGCG GCCGATGGGG CCCCACACAA ACACAATGTG ATTGGGCATA CGAGGGGACC 240

AGCGTGATGG TGACCGTGGG GGCCGAAGGG CCTCTGAAAG GAGTGCAGCT GTGGCGGGCG 300

CCAGGCACCG GCCAGTATCT GATCTCAGCC TACGGAGCCG CAGGCGGCAA GGGCGCCAAG 360

AACCACCTGT CGCGGGCGCA TGGCGTCTTC GTCTCAGGGA TCTTCTCCCT AGGTCGTGGG 420

GAGCAGCTGT ATATCCTAGT GGGGCAGCAG GGAGAGGACG CCTGTCCAGG AGGTAGCCCG 480

GAGAGCCAAC TCGTCTGTCT TGGAGAGTCT CAGTCCACTG AAGAGCACAC GGCGGCGGCC 540

GATGAAACCG AAAGAGTCCG GGGGTCGCAG CACTGGGCGG GAGGTGGTGG GGGTGGAGGG 600

GGCGCCACCT ACGTCTTCCG GGTACGCGCT GCTGGCCCCA TAGCTACGCG CCGGCGAGCT 660

GGAGCCGCTG CTGGTGGCTG CCTGAGGCGG CAGGACCGAG CCCGGACTCA GGCCGCCCCA 720

GAGAAACTGG AAAACCGGTC GGCGGCGCCA GGGAGCGGCG GGAGAGGAGG GGCGGCAGGT 780

GGAGGGGGCG GCTGGACGTC ACAGGCCCGC TCTCCGCAGT TTGGCCGCTC ACTGAAGGAA 840

GGGGCAGAGG GCGGCCAGGG ATGTGCCGAG GCCAGGGCTA CACTCGGCTG GGCCGCAGTC 900

GGCGGCTTCG GGGGCGGTGG CGGAGCCTGC ACTGCTGGTG GAGGAGGCGG TGGCTACCGG 960

GGGGGTGATG CCTCAGAGAC TGACATCTTC TGGGCTGATG GGGAAGATGG GGTATCTTTC 1020

ATACACCCCA GCAGTGAACT CTACCTGCAG CCTCTGGCAG TCATAGAGAA CCATGGAGAG 1080

GTGGAAATCC GAAGGCACCA CAATTGCAGT CATTGTTCTT TGAAAGACTG CCAGTGGCAG 1140

GCTGAGCTTC ATTTGACTGA ATGCATGTGC CCAGAAGGCA TGGAGCTAGC TGTGGATAAC 1200

ATCACTTGCA GAGACCTGCC AACCCCCTCA AGCCCACTGG TTCTGATGGT GGCTGTAGTG 1260

GTGACCTTGA TACTGAGCCT CCTTATGGTG TGTGGGGTCC TGATTTTGGT GAACCAGAAG 1320

AAGTGGCAGG GCCTATGGGG GTCCAGGCGG CCAGATCCTG AGCTTGAGCT GAGCAAGCTT 1380

CGAACCTCTG CCATCAGGAC AGCCCCCAAT CCCTATTACT GCCAGGTAGG GCTTGGTCTG 1440

ACCCAGTCGT GGCCTCTGCC CCCAGGGCTC ACCGAGGTTT CCCCAGCCAA TGTCACTCTG 1500

CTCAGAGCCC TGGGCCACGG TGCCTTTGGG GAAGTGTATG AGGGATTGGT AATTGGCCTT 1560

CCTGGGGACT CCAGCCCCCT ACAGGTGGCA ATCAAGACTC TGCCAGATCT CTGTTCTCAT 1620

CAGGATGAGT TGGATTTTCT CATGGAGGCG CTCATCATCA GTAAGTTCAG CCATCAGAAC 1680

ATCGTGCGCT GTGTGGGGCT CAGCCTCAGG GCTGTGCCTC GCCTCATTCT GCTGGAACTG 1740

ATGTCTGGAG GGGACATGAA GAGTTTCCTG AGGCAGAGTC GTCCCAACCT GGGTCAGCCA 1800

TCACCTCTGG CCATGCAGGA CCTGCTGCAG CTGGCCCAGG ACATAGCCCA GGGCTGCCAC 1860

TACCTTGAGG AAAATCGCTT CATCCACAGG GACATTGCCG CCAGGAACTG TCTGCTGAGC 1920

TGCACTGGGC CCAGTCGTGT TGCCAAGATT GGGGACTTTG GGATGGCAAG AGATATCTAC 1980

CGGGCCAATT ATTATCGTAA GGCAGGGCAG GCCTTGCTCC CAGTCAAATG GATGCCCCCA 2040

GAGGCCCTTC TAGAGGGGAT CTTCACGTCA AAGACAGACT CCTGGTCTTT TGGGGTACTG 2100

CTCTGGGAGA TCTTCTCACT GGGTTACATG CCCTACCCTG GGCATACCAA CCAAGAGGTG 2160

CTGGACTTCA TCATTGCAGG GAGCCGGATG GACCCTCCTC AGGGCTGTCC AGGACCTGTG 2220

TACCGCATCA TGACCCAGTG TTGGCAGCAT CAACCTGAAC TCCGCCCCAA CTTTGCCAGC 2280

ATCTTGGAGC GCCTTCAATA CTGTACTCAG GACCCTGATG TGCTTAATTC ACCACTGCCA 2340

ATAGAACTGA AGCCCACTCT GGAGGATGAA GGGGCTTCTG ACCTGGGGAA CAGGTCCTTG 2400

GAGGGCCTAA GATCCCCACA ACCCCAGGAC CTGAGCCCAG AGAATTTGAA AAACTGGGGA 2460

AGGAGGCCTC TTGTCCCTCA CCTGTCCTCT GGCCTCAAGC CCCTCAAATC CCGAGGTCTC 2520

CAACCTCAGA ATCTTTGGAA TCCCACCTAT GGCTCT 2556

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         ++l+ralG+GafGevyeglv+glpgd+s+l+va+ktlp+ +s+qdeldfl+ealiiskf+

Q: 498   VTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPDLCSHQDELDFLMEALIISKFS  557

         689*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr++G+sl+++prlillel++GGd+ksflr+srp+  q+s+lam+dll++a+d+a+

Q: 558   HQNIVRCVGLSLRAVPRLILLELMSGGDMKSFLRQSRPNLGQPSPLAMQDLLQLAQDIAQ  617

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+lls++Gpsrvaki+dfGmardiyra+yyrk+g+allpvkw

Q: 618   GCHYLEENRFIHRDIAARNCLLSCTGPSRVAKIGDFGMARDIYRANYYRKAGQALLPVKW  677

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppea+leGiftsktd+wsfGvllwe+fslG++pypg++nqevl++++ G+r+d+p+++p

Q: 678   MPPEALLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIIAGSRMDPPQGCP  737

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pe rp+f+silerlq+

Q: 738   GPVYRIMTQCWQHQPELRPNFASILERLQY  767

         ****************************97

Domain Sequence
(FASTA)

VTLLRALGHG AFGEVYEGLV IGLPGDSSPL QVAIKTLPDL CSHQDELDFL MEALIISKFS 60

HQNIVRCVGL SLRAVPRLIL LELMSGGDMK SFLRQSRPNL GQPSPLAMQD LLQLAQDIAQ 120

GCHYLEENRF IHRDIAARNC LLSCTGPSRV AKIGDFGMAR DIYRANYYRK AGQALLPVKW 180

MPPEALLEGI FTSKTDSWSF GVLLWEIFSL GYMPYPGHTN QEVLDFIIAG SRMDPPQGCP 240

GPVYRIMTQC WQHQPELRPN FASILERLQY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR026984	; LTK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013