EKS-ICT-00455

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00455

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK2	583.2	5.6E-176	13	271	259

Status

Unreviewed

Ensembl Protein

ENSSTOP00000008004

UniProt Accession

I3MCL2;

Protein Name

Protein Synonyms/Alias

Gene Name

CAMK2A

Gene Synonyms/Alias

CAMK2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000008932	ENSSTOP00000008004	ENSSTOT00000008931

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 60

ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 120

EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 180

SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 240

TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 300

GAILTTMLAT RNFSGGKSGG NKKNDGVKKR KSSSSVQLME SSESTNTTIE DEDTKVRKQE 360

IIKVTEQLIE AISNGDFESY TKMCDPGMTA FEPEALGNLV EGLDFHRFYF ENLWSRNSKP 420

VHTTILNPHI HLMGDESACI AYIRITQYLD AGGIPRTAQS EETRVWHRRD GKWQIVHFHR 480

SGAPSVLPH 489

Nucleotide Sequence
(FASTA)

ATGGCCACCA TCACCTGCAC CCGCTTCACA GAAGAGTATC AGCTCTTCGA GGAACTGGGA 60

AAGGGAGCCT TCTCGGTCGT GCGCAGGTGT GTGAAGGTGC TGGCTGGCCA GGAGTATGCT 120

GCTAAGATCA TCAACACCAA GAAGCTCTCA GCCAGAGACC ATCAGAAGCT GGAGCGCGAA 180

GCCCGCATCT GCCGCCTGCT GAAGCACCCC AACATCGTCC GGCTCCACGA CAGCATCTCT 240

GAGGAGGGAC ACCATTACCT GATCTTCGAC CTGGTCACTG GCGGGGAGCT GTTTGAAGAC 300

ATCGTGGCCC GGGAGTATTA CAGTGAGGCT GATGCCAGTC ACTGTATCCA GCAGATCCTG 360

GAGGCCGTGC TGCACTGCCA CCAGATGGGG GTGGTGCACC GGGACCTGAA GCCGGAGAAC 420

CTGTTGCTGG CCTCCAAGCT CAAGGGCGCT GCCGTGAAGC TGGCGGACTT TGGCCTGGCC 480

ATAGAGGTGG AGGGGGAGCA GCAGGCATGG TTTGGGTTTG CAGGGACACC TGGATACCTC 540

TCCCCAGAAG TGCTGCGGAA GGACCCATAC GGGAAGCCTG TGGACCTGTG GGCCTGCGGG 600

GTCATCCTGT ACATCCTGCT GGTTGGATAC CCCCCATTCT GGGATGAGGA CCAGCACCGC 660

CTGTACCAGC AGATCAAAGC CGGTGCCTAT GATTTCCCAT CACCAGAATG GGACACCGTC 720

ACCCCAGAAG CCAAGGATCT GATCAATAAG ATGCTGACCA TCAACCCATC CAAACGCATC 780

ACAGCTGCAG AGGCCCTCAA GCACCCCTGG ATCTCGCACC GGTCCACTGT GGCCTCCTGC 840

ATGCACAGAC AGGAGACCGT GGACTGCCTG AAGAAGTTCA ATGCCAGGAG GAAACTGAAG 900

GGAGCCATTC TGACCACAAT GCTGGCCACC AGGAACTTCT CTGGAGGGAA GAGTGGAGGG 960

AACAAGAAGA ACGATGGTGT GAAGAAAAGA AAGTCCAGTT CCAGCGTTCA GTTAATGGAG 1020

TCTTCTGAGA GCACCAACAC CACCATTGAA GATGAAGACA CCAAAGTGCG GAAACAGGAA 1080

ATTATAAAAG TGACAGAGCA GCTGATTGAA GCCATAAGCA ATGGAGATTT TGAGTCCTAC 1140

ACGAAGATGT GCGACCCCGG GATGACGGCC TTCGAACCCG AGGCCCTGGG GAACCTGGTC 1200

GAGGGCCTGG ACTTCCATCG ATTCTATTTT GAAAACCTGT GGTCCCGGAA CAGCAAGCCC 1260

GTGCACACCA CCATCCTGAA CCCCCACATC CACCTGATGG GGGACGAGTC CGCCTGCATC 1320

GCCTACATCC GCATCACGCA GTATCTGGAT GCGGGCGGCA TTCCCCGCAC CGCCCAGTCA 1380

GAGGAGACCC GCGTCTGGCA CCGCAGGGAT GGCAAATGGC AGATTGTCCA CTTCCACAGA 1440

TCCGGGGCGC CCTCCGTCCT GCCCCATTGA 1470

Domain Profile

S: 1     yqlfeelgkgafsvvrrcvkvttgqeyaakiintkklsardhqklerearicrllkhpni  60

         yqlfeelgkgafsvvrrcvkv +gqeyaakiintkklsardhqklerearicrllkhpni

Q: 13    YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI  72

         9***********************************************************

S: 61    vrlhdsiseegfhylvfdlvtggelfedivareyyseadashciqqilesvlhihqngvv  120

         vrlhdsiseeg+hyl+fdlvtggelfedivareyyseadashciqqile+vlh+hq+gvv

Q: 73    VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV  132

         ************************************************************

S: 121   hrdlkpenlllaskakgaavkladfglaievqgdqqawfgfagtpgylspevlrkdpygk  180

         hrdlkpenlllask+kgaavkladfglaiev+g+qqawfgfagtpgylspevlrkdpygk

Q: 133   HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK  192

         ************************************************************

S: 181   pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml  240

         pvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdlinkml

Q: 193   PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML  252

         ************************************************************

S: 241   tinpakritadealkhpwi  259

         tinp+krita+ealkhpwi

Q: 253   TINPSKRITAAEALKHPWI  271

         ******************8

Domain Sequence
(FASTA)

YQLFEELGKG AFSVVRRCVK VLAGQEYAAK IINTKKLSAR DHQKLEREAR ICRLLKHPNI 60

VRLHDSISEE GHHYLIFDLV TGGELFEDIV AREYYSEADA SHCIQQILEA VLHCHQMGVV 120

HRDLKPENLL LASKLKGAAV KLADFGLAIE VEGEQQAWFG FAGTPGYLSP EVLRKDPYGK 180

PVDLWACGVI LYILLVGYPP FWDEDQHRLY QQIKAGAYDF PSPEWDTVTP EAKDLINKML 240

TINPSKRITA AEALKHPWI 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004683	; F:calmodulin-dependent protein kinase activity

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543	; Ca/CaM-dep_prot_kinase-assoc.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08332	; CaMKII_AD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013