EKS-ICT-00105

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00105

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	464.9	5.6E-140	363	613	251

Status

Unreviewed

Ensembl Protein

ENSSTOP00000008275

UniProt Accession

I3MD63;

Protein Name

Protein Synonyms/Alias

Gene Name

ITK

Gene Synonyms/Alias

ITK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000009223	ENSSTOP00000008275	ENSSTOT00000009225

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MNNLILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FEDRHGKKRT LKGSIELSRI 60

KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVSKY 120

HPNFWMDGRW RCCSQLEKLA VGCAQYDPTK NASKKPLPPT PEDNRRSLQE PEETLVIALY 180

DYQTNDPQEL ALQRNEEYYL LDSSEIHWWR VQDKNGHEGY VPSSYLVEKS PNNLETYEWY 240

NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTLSVFTK AIVSENNPCI KHYHIKETND 300

NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCS WRQKAPVTAG LRYGKWVIHP 360

SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420

LHGVCLEQAP ICLVFEFMAH GCLSDYLRSQ RGLFAAGTLL GMCLDVCEGM AYLEKECVIH 480

RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540

VWSFGVLMWE VFSEGRIPYE NRSNSEVVED ISTGFRLYKP RLASSHIYQI MNHCWKERPE 600

DRPPFSRLFG QLAEIAESGL 620

Nucleotide Sequence
(FASTA)

ATGAACAACT TGATCCTCCT GGAAGAACAG CTGATCAAGA AATCACAACA AAAGAGAAGA 60

ACTTCTCCCT CTAATTTTAA GGTCCGCTTC TTTGTTTTAA CCAAAACCAG CCTGGCATAC 120

TTTGAGGATC GTCATGGGAA AAAGCGTACA TTGAAGGGCT CCATTGAACT CTCCCGAATC 180

AAATGTGTTG AGATTGTGAA AAGTGACATT AGCATCCCAT GCCACTATAA GTACCCGTTT 240

CAGGTTGTGC ATGACAACTA CCTACTGTAT GTGTTTGCTC CAGACCGTGA GAGTCGGCAG 300

CGCTGGGTGC TGGCCCTTAA AGAAGAAACG AGGAATAATA ATAGTTTGGT GTCCAAGTAT 360

CATCCTAATT TCTGGATGGA TGGGAGGTGG AGGTGCTGTT CTCAGCTGGA GAAGCTTGCA 420

GTAGGCTGTG CCCAGTATGA TCCAACTAAG AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480

CCTGAAGATA ACAGGCGATC CCTGCAGGAA CCTGAAGAAA CCCTGGTTAT TGCCCTGTAT 540

GACTACCAAA CCAACGATCC CCAGGAACTG GCCCTGCAGC GCAATGAAGA GTACTACCTA 600

CTGGACAGTT CTGAGATCCA CTGGTGGAGA GTTCAAGACA AGAATGGGCA TGAAGGATAT 660

GTACCAAGCA GTTATCTGGT GGAAAAATCT CCTAATAACC TGGAAACCTA TGAGTGGTAT 720

AACAAGAGCA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780

GCCTTCATGG TCCGAGATTC CAGGACTCCG GGAACATACA CGCTCTCTGT TTTCACCAAG 840

GCTATTGTGA GTGAGAACAA CCCCTGTATA AAGCATTATC ACATCAAAGA AACAAATGAC 900

AACCCCAAGC GGTACTATGT GGCTGAGAAG TACGTGTTTG ACTCCATCCC TCTCCTCATC 960

AATTATCACC AACACAACGG AGGAGGTCTG GTCACCCGAC TCCGGTATCC AGTTTGTTCC 1020

TGGAGGCAGA AAGCTCCTGT CACAGCAGGG CTGAGATATG GGAAATGGGT AATCCATCCC 1080

TCGGAGCTCA CTTTTGTGCA GGAGATTGGC AGTGGACAGT TTGGGTTGGT GCATCTTGGC 1140

TACTGGCTCA ACAAGGACAA GGTTGCTATC AAAACCATTC AGGAAGGGGC GATGTCAGAA 1200

GAGGACTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CCCACCCCAA ACTGGTCCAG 1260

CTCCATGGAG TGTGCCTGGA GCAGGCCCCC ATCTGCCTCG TGTTTGAGTT CATGGCGCAT 1320

GGCTGCCTGT CAGATTACTT GCGCAGCCAG AGGGGACTCT TTGCAGCAGG AACCTTGCTT 1380

GGCATGTGCC TGGATGTGTG TGAAGGCATG GCCTACCTGG AAAAGGAGTG TGTCATCCAC 1440

AGAGATTTGG CTGCCAGAAA TTGTTTGGTG GGAGAAAATC AAGTCATCAA GGTGTCCGAT 1500

TTTGGGATGA CAAGGTTTGT CCTTGATGAT CAATACACCA GTTCCACAGG CACCAAATTC 1560

CCGGTGAAGT GGGCATCTCC AGAAGTGTTT TCTTTCAGTC GCTATAGCAG CAAGTCAGAT 1620

GTGTGGTCAT TTGGTGTGCT GATGTGGGAA GTCTTCAGCG AAGGCAGAAT CCCATATGAA 1680

AACAGAAGCA ACTCAGAGGT AGTGGAAGAC ATCAGTACCG GATTTCGGTT ATACAAGCCC 1740

CGATTAGCCT CCTCCCACAT CTACCAGATC ATGAATCATT GCTGGAAAGA GAGACCAGAA 1800

GACCGGCCAC CCTTCTCCAG ACTCTTTGGT CAACTGGCTG AAATCGCAGA ATCAGGACTT 1860

TAG 1863

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvql+

Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLH  422

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvcl+q+pi++v+e++++gcl++ylr++++ +++ +ll mc dvcegm+yle++++ihrd

Q: 423   GVCLEQAPICLVFEFMAHGCLSDYLRSQRGLFAAGTLLGMCLDVCEGMAYLEKECVIHRD  482

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw

Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevfseg++pye++snsevve++s+g+rly+p+las+++y++m++cwke+pe+r

Q: 543   SFGVLMWEVFSEGRIPYENRSNSEVVEDISTGFRLYKPRLASSHIYQIMNHCWKERPEDR  602

         ************************************************************

S: 241   ptfkellsale  251

         p f++l+ +l+

Q: 603   PPFSRLFGQLA  613

         ******98875

Domain Sequence
(FASTA)

LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLH 60

GVCLEQAPIC LVFEFMAHGC LSDYLRSQRG LFAAGTLLGM CLDVCEGMAY LEKECVIHRD 120

LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180

SFGVLMWEVF SEGRIPYENR SNSEVVEDIS TGFRLYKPRL ASSHIYQIMN HCWKERPEDR 240

PPFSRLFGQL A 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013