EKS-ICT-00324

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00324

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	363.2	9.1E-109	167	583	417

Status

Unreviewed

Ensembl Protein

ENSSTOP00000008324

UniProt Accession

I3MD92;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK1

Gene Synonyms/Alias

EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000009274	ENSSTOP00000008324	ENSSTOT00000009278

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

622

Protein Sequence
(FASTA)

MLGGGSGARE DKAEGARAGA IASPPAIDFP AEGSDPKYDE SDVPAELQVL KEPLQQPTFP 60

FAVANQLLLV SLLEHLSHVH EPNVPRSKQV FKLLCETFIK MGLLSSFTCS DEFSSLRLHH 120

NRAITHLMRS AKERVRQDPC EDNSYMQKIR SREIAFEAQT SRYLNEFEEI AILGKGGYGR 180

VYKVRNKLDG QHYAIKKILI KGATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVV 240

QPQAGRVPIQ LPSLEVLSDY FSSRDQYGVK DNESSSSSII FAEFTSEKEK PFGECDIENQ 300

NNKLVNYTTD LVIRDSNELE SSINLQENGL ADLSDRSIVK HQLPVRHNSD LEGNFTSTEE 360

SSEENFNLLG QTEVQYHLML HIQMQLCELS LFDWIAERNK RNQECVDEAA CPYVMASVAT 420

KIFQELVEGV FYIHDMGIVH RDLKPRNIFL HGPDQQVKIG DFGLACTDII QKNSDWTNRN 480

GKGTPTHTSR VGTCLYASPE QLEGSEYDAK SDMYSLGVIL LELFQPFGTE MERAAVLTGV 540

RTGHIPESLS KRCPVQTKYI QHLTRRNASQ RPSALQLLQS ELFQTSGNVN LTLQMKIIEQ 600

EKEIEELKKQ LSLLSQDRGL KD 622

Nucleotide Sequence
(FASTA)

ATGCTGGGGG GCGGCTCTGG TGCTCGGGAG GACAAAGCCG AGGGCGCCCG GGCGGGAGCT 60

ATAGCCTCGC CGCCCGCTAT CGACTTTCCG GCCGAGGGCT CGGATCCCAA GTATGATGAA 120

TCTGATGTGC CAGCAGAACT CCAGGTGTTA AAAGAACCCC TACAACAGCC AACTTTCCCT 180

TTTGCAGTTG CAAACCAGCT ACTGCTTGTT TCTTTGCTGG AACACTTGAG TCATGTGCAT 240

GAACCAAACG TACCTCGATC AAAACAGGTG TTTAAATTAC TTTGTGAGAC CTTTATCAAA 300

ATGGGGCTGC TGTCTTCTTT CACCTGCAGT GATGAGTTTA GCTCATTGAG ACTACATCAC 360

AACAGAGCTA TTACTCATTT AATGAGGTCT GCCAAAGAGA GAGTTCGCCA GGATCCTTGT 420

GAGGATAATT CTTATATGCA GAAGATCAGA TCCAGGGAAA TAGCCTTTGA AGCACAAACT 480

TCACGTTACT TGAATGAATT TGAAGAAATT GCCATCTTAG GAAAAGGTGG ATATGGAAGA 540

GTATACAAGG TCAGGAATAA ATTAGATGGC CAGCATTATG CAATTAAGAA AATTCTGATT 600

AAGGGTGCAA CTAAGACTGA CTGCATGAAG GTACTACGGG AAGTAAAGGT GCTGGCAGGT 660

CTTCAACACC CTAATATTGT AGGCTATCAT ACTGCATGGA TAGAACATGT TCATGTGGTC 720

CAGCCCCAAG CAGGCAGAGT TCCTATTCAG TTGCCCTCTC TTGAAGTGCT CTCTGATTAT 780

TTTTCCTCCA GGGATCAATA TGGTGTTAAA GACAATGAAA GTAGCAGCTC GTCAATCATC 840

TTTGCTGAGT TTACCTCAGA AAAAGAAAAA CCCTTTGGAG AATGTGACAT CGAAAATCAG 900

AATAACAAAT TGGTGAACTA CACCACAGAT TTAGTTATAA GGGACAGCAA TGAACTTGAG 960

TCATCCATTA ATCTCCAGGA AAATGGCTTG GCTGATTTGT CTGACAGATC GATTGTCAAA 1020

CATCAGCTGC CAGTCAGGCA TAATTCAGAC TTGGAAGGGA ATTTCACATC CACTGAAGAG 1080

TCTTCTGAAG AAAACTTTAA CTTGTTGGGA CAGACAGAGG TGCAGTACCA CCTGATGTTG 1140

CATATCCAAA TGCAGCTGTG TGAGCTCTCC CTGTTTGACT GGATAGCCGA GAGGAACAAG 1200

CGGAACCAAG AGTGTGTGGA TGAAGCTGCC TGTCCTTATG TTATGGCCAG TGTTGCAACA 1260

AAAATTTTTC AAGAATTGGT GGAAGGTGTA TTTTACATAC ATGACATGGG AATTGTACAC 1320

AGAGATCTGA AGCCTAGAAA TATTTTTCTT CATGGTCCTG ATCAGCAAGT TAAAATAGGA 1380

GACTTTGGCC TGGCCTGCAC AGACATCATA CAGAAGAATT CAGATTGGAC CAATAGAAAT 1440

GGGAAGGGTA CACCAACACA TACTTCCAGA GTGGGTACTT GTCTGTACGC CTCACCTGAG 1500

CAATTGGAAG GATCTGAGTA CGATGCCAAG TCAGATATGT ACAGCTTGGG TGTGATCCTG 1560

CTTGAACTCT TTCAGCCCTT TGGGACAGAA ATGGAGCGAG CAGCAGTTTT AACAGGAGTA 1620

AGAACTGGTC ACATACCTGA ATCCCTTAGT AAAAGGTGTC CAGTACAAAC CAAGTATATC 1680

CAGCACTTAA CTCGGAGGAA TGCATCTCAG AGACCATCTG CTCTTCAGCT GCTGCAGAGT 1740

GAACTTTTCC AAACTTCTGG AAATGTTAAT CTCACCCTAC AGATGAAGAT AATAGAGCAA 1800

GAAAAAGAAA TTGAAGAACT AAAGAAACAG CTAAGCCTTC TTTCTCAAGA CAGAGGTCTT 1860

AAGGAT 1866

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         feei++lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni

Q: 167   FEEIAILGKGGYGRVYKVRNKLDGQHYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  226

         89**********************************************************

S: 60    vrYfaawleekeesl.................................tdsseveaeael  86

         v Y++aw+e+ +  +                                 ++ss ++ae+++

Q: 227   VGYHTAWIEHVHVVQpqagrvpiqlpslevlsdyfssrdqygvkdnesSSSSIIFAEFTS  286

         ************999*******************************95449999999***

S: 87    eesesseesdtk................................................  98

         e+++ + e d +

Q: 287   EKEKPFGECDIEnqnnklvnyttdlvirdsnelessinlqengladlsdrsivkhqlpvr  346

         *99999999999999*********************************************

S: 99    ................................llyiqmelceketLkdwiderk......  120

                                         +l+iqm+lce  +L+dwi er+

Q: 347   hnsdlegnftsteesseenfnllgqtevqyhlMLHIQMQLCE-LSLFDWIAERNkrnqec  405

         ******************************************.********999888888

S: 121   llesrselvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLa  174

         ++e+++ +vm     ++f++l+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa

Q: 406   VDEAACPYVMasvatKIFQELVEGVFYIHDMGIVHRDLKPRNIFLHgPDQQVKIGDFGLA  465

         8899999999************************************99************

S: 175   talaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLly  234

         ++++ +++ d+++++ +++++ht++vgt+ly+sPeqle+s+Y++k+D++sLG+il+eL++

Q: 466   CTDIIQKNSDWTNRNGKGTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQ  525

         ************************************************************

S: 235   pfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292

         pf temer+ +lt +r+g+ipe++++++p++ k++q+l++r++++Rpsa +ll+sel+

Q: 526   PFGTEMERAAVLTGVRTGHIPESLSKRCPVQTKYIQHLTRRNASQRPSALQLLQSELF  583

         *******************************************************986

Domain Sequence
(FASTA)

FEEIAILGKG GYGRVYKVRN KLDGQHYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60

VGYHTAWIEH VHVVQPQAGR VPIQLPSLEV LSDYFSSRDQ YGVKDNESSS SSIIFAEFTS 120

EKEKPFGECD IENQNNKLVN YTTDLVIRDS NELESSINLQ ENGLADLSDR SIVKHQLPVR 180

HNSDLEGNFT STEESSEENF NLLGQTEVQY HLMLHIQMQL CELSLFDWIA ERNKRNQECV 240

DEAACPYVMA SVATKIFQEL VEGVFYIHDM GIVHRDLKPR NIFLHGPDQQ VKIGDFGLAC 300

TDIIQKNSDW TNRNGKGTPT HTSRVGTCLY ASPEQLEGSE YDAKSDMYSL GVILLELFQP 360

FGTEMERAAV LTGVRTGHIP ESLSKRCPVQ TKYIQHLTRR NASQRPSALQ LLQSELF 417

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013