EPS-ICT-00118

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ICT-00118

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	279.4	3.2E-83	131	329	199

Status

Unreviewed

Ensembl Protein

ENSSTOP00000008671

UniProt Accession

I3ME00;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2

Gene Synonyms/Alias

PPEF2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000009657	ENSSTOP00000008671	ENSSTOT00000009665

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

752

Protein Sequence
(FASTA)

MGSSTSIHHH FAFQNAEKAF KAAILIQRWY RRYVARLEMR RQCTWSIFQS IEYAGQQDQV 60

KLHDFFSYLM DHFTPDSHHE KEFLDRMFTE ERFPQEAEME KYSDYESIEV PDSYTGPHLS 120

FPLLPDHATA LVEAFRLKQQ LHARYVLNLL YEARKHLAQL PNINRLSTCY SEEITVCGDL 180

HGQLDDLIFI FYKNGLPSPE RAYVFNGDFV DRGKDSIEIL MVLFAFMLVY PKEFHLNRGN 240

HEDHLMNLRY GFTKEVMQKY KVHGKKILRI LQDVFCWLPL ATLIDEKVLI LHGGVSDRTD 300

LELLAKLDRH KIVSTLRYKI RKENDRQTEE KRKAHQTSSA QTSTPWFLPQ SRSPPSLPFH 360

LGSDKAHKAS LSSSVPCSAL LEHTELAWLG RRSVDQELER CQQRASFPGI WEKEEPLPQT 420

SEAHTVPGEL PEPTLQEWRQ VVDILWSDPM MQEGCKANTV RGGGCYFGPD VTEQLLQKYN 480

LQFLIRSHEC KPEGYEFCHN RKVLTIFSAS NYYEVGSNRG AYVKLGPSLS PYIVQYQANK 540

ATHMLTMRQR ISRVEESALR ALREKLFAHS SDLLDEFKKH DADKTGLITL TDWATAVESV 600

LHLGLPWRML RPQLVNSSMN NTLEYRSWLK DLAKEQLSRE NIQSSLLETL YRNRSNLETI 660

FRIIDSDHSG FISLDEFRQT WKLFSSHMNI DITDDCICDL ARSIDFNKDG HIDINEFLEA 720

FRLVEQSSSE GQAADCPQST NANDSGCSSS GA 752

Nucleotide Sequence
(FASTA)

ATGGGGAGCA GCACCTCTAT CCATCATCAT TTTGCTTTTC AGAATGCAGA GAAAGCCTTC 60

AAGGCAGCGA TCCTAATCCA GAGATGGTAC CGGCGCTACG TGGCCCGCCT GGAGATGAGA 120

CGGCAGTGCA CCTGGAGCAT CTTCCAGTCT ATAGAGTATG CTGGGCAGCA AGACCAGGTC 180

AAGCTCCATG ATTTCTTCAG TTACCTTATG GATCACTTCA CCCCAGACAG CCACCATGAG 240

AAGGAGTTCC TGGACCGCAT GTTCACTGAG GAGAGATTCC CCCAGGAGGC CGAGATGGAG 300

AAATACAGTG ACTACGAATC CATCGAGGTG CCGGACAGTT ACACAGGACC ACATCTCTCC 360

TTCCCGCTCC TCCCTGACCA CGCCACTGCC CTGGTGGAAG CTTTCAGACT GAAACAACAG 420

CTCCATGCTA GATACGTCTT GAATCTTTTG TATGAGGCCA GGAAACACCT GGCGCAGCTG 480

CCCAACATCA ACCGACTCTC CACCTGTTAC AGCGAGGAGA TCACAGTGTG TGGAGATTTA 540

CATGGCCAGT TAGATGACTT AATATTTATA TTTTATAAGA ATGGCCTCCC GTCACCAGAG 600

CGAGCATACG TGTTCAATGG TGACTTCGTG GATCGGGGCA AGGATTCGAT AGAGATCCTG 660

ATGGTTCTTT TTGCCTTCAT GTTGGTTTAC CCCAAAGAGT TCCATCTTAA CCGAGGAAAC 720

CACGAGGACC ATTTGATGAA CTTACGATAT GGCTTCACCA AGGAAGTGAT GCAAAAATAT 780

AAGGTGCATG GAAAGAAAAT ATTAAGAATT CTTCAAGATG TGTTCTGTTG GCTTCCATTG 840

GCCACTCTGA TTGATGAGAA AGTCCTGATT CTTCACGGTG GAGTATCAGA CAGGACTGAC 900

CTGGAGCTTT TGGCTAAACT AGACAGGCAC AAGATCGTTT CCACGCTGAG GTACAAGATA 960

AGAAAGGAAA ATGACAGACA GACAGAGGAG AAGAGAAAAG CACACCAGAC AAGCTCTGCG 1020

CAGACGTCCA CCCCGTGGTT TCTTCCCCAA AGCCGCTCTC CCCCTTCTCT ACCCTTTCAC 1080

CTGGGCTCAG ACAAGGCCCA CAAAGCCAGC CTGTCCTCCA GCGTCCCCTG CAGCGCCCTT 1140

CTTGAGCACA CAGAGCTGGC CTGGCTGGGA CGGCGCTCGG TGGACCAGGA GCTGGAGCGG 1200

TGCCAGCAGC GAGCCAGCTT CCCGGGGATC TGGGAGAAGG AGGAGCCCTT GCCCCAGACC 1260

TCGGAAGCCC ACACCGTCCC TGGAGAGCTG CCAGAGCCCA CTCTGCAGGA GTGGAGGCAG 1320

GTTGTCGACA TCCTGTGGAG TGATCCCATG ATGCAGGAGG GCTGCAAAGC AAACACCGTT 1380

AGAGGAGGAG GCTGTTACTT TGGGCCTGAT GTGACAGAAC AGTTGTTACA GAAATACAAC 1440

CTGCAGTTTC TGATCCGTTC CCATGAATGC AAACCTGAAG GCTATGAGTT CTGCCACAAC 1500

CGCAAAGTGT TAACCATCTT TTCTGCCTCC AACTACTATG AAGTTGGCAG TAACAGAGGG 1560

GCCTATGTCA AACTGGGGCC ATCCCTGAGC CCATATATTG TGCAGTATCA AGCTAACAAG 1620

GCAACCCACA TGCTCACCAT GAGGCAAAGG ATTAGCAGAG TAGAGGAATC AGCTCTGAGA 1680

GCTCTGCGGG AAAAGCTATT TGCTCATTCC TCAGACCTCC TTGATGAATT TAAGAAGCAC 1740

GATGCAGATA AAACTGGTTT AATCACCCTG ACTGACTGGG CGACAGCTGT GGAGTCCGTG 1800

TTGCATCTGG GATTGCCATG GCGGATGCTG AGGCCACAGC TGGTGAACAG CTCAATGAAC 1860

AACACACTGG AGTACAGGTC CTGGTTGAAG GACTTGGCCA AAGAACAGCT GAGCCGTGAG 1920

AATATACAGT CAAGTTTGCT GGAAACCCTG TATCGAAACC GATCCAACCT GGAGACTATT 1980

TTTAGGATCA TAGACAGCGA TCACTCAGGG TTCATCTCCC TGGATGAGTT CAGGCAGACA 2040

TGGAAGCTAT TCAGCTCTCA CATGAACATC GACATCACAG ATGACTGCAT CTGTGACCTT 2100

GCCCGGAGCA TTGATTTCAA CAAGGATGGC CACATCGATA TCAATGAGTT CCTGGAGGCC 2160

TTTCGCCTTG TGGAGCAATC CTCCTCAGAG GGCCAAGCCG CAGACTGCCC ACAGTCCACA 2220

AATGCTAATG ACAGTGGCTG CAGTAGTTCA GGTGCC 2256

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         l+e+f+ k++lha+yvl++l+ea+k l qlpni+++st+ s+e+tv+GdlhG+lddl+++

Q: 131   LVEAFRLKQQLHARYVLNLLYEARKHLAQLPNINRLSTCYSEEITVCGDLHGQLDDLIFI  190

         89**********************************************************

S: 64    lkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnary  123

         ++knGlPs +++yvfnGdfvdrGk ++e+l+vl +++lv+P++ +lnrGnhed++mn+ry

Q: 191   FYKNGLPSPERAYVFNGDFVDRGKDSIEILMVLFAFMLVYPKEFHLNRGNHEDHLMNLRY  250

         ************************************************************

S: 124   GfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksverk  183

         Gf+kev++kyk +gk+ilril++v+ wlPl++++d++vl++hGG+s+ t+l+ll +++r+

Q: 251   GFTKEVMQKYKVHGKKILRILQDVFCWLPLATLIDEKVLILHGGVSDRTDLELLAKLDRH  310

         ************************************************************

S: 184   krksvllpPeessrdlgrl  202

         k +s l+     + d+ +

Q: 311   KIVSTLRYKIRKENDRQTE  329

         ******9877655554333

Domain Sequence
(FASTA)

LVEAFRLKQQ LHARYVLNLL YEARKHLAQL PNINRLSTCY SEEITVCGDL HGQLDDLIFI 60

FYKNGLPSPE RAYVFNGDFV DRGKDSIEIL MVLFAFMLVY PKEFHLNRGN HEDHLMNLRY 120

GFTKEVMQKY KVHGKKILRI LQDVFCWLPL ATLIDEKVLI LHGGVSDRTD LELLAKLDRH 180

KIVSTLRYKI RKENDRQTE 199

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00612	; IQ; 1.
PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013