EKS-ICT-00409

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00409

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	377.0	4.1E-113	298	568	271

Status

Unreviewed

Ensembl Protein

ENSSTOP00000008672

UniProt Accession

I3ME01;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000009661	ENSSTOP00000008672	ENSSTOT00000009667

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

645

Protein Sequence
(FASTA)

MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG EDSAFQEPDS 60

PLPPARSPTE PGPERRRSPG PAPGSPGELE EDMLLQDPCP SADAAGGGAE GDSWEEEGFG 120

SSSPVKSPAA AYFLGSSFSP VRCGGPGDAS PRGCGARQSG EGPCSPLPDH PGTPPHKTFR 180

KLRLFDTPHT PKSLLSKARG IDSSSVKLRG GSLFMDTEKS GKREFDTRQT PQVNINPFTP 240

DSVLLHSSGQ CRRRKRAYWN DSCEDIEGSD YELEDETRPA KRITITESNM KSRYTTEFHE 300

LEKIGSGEFG SVFKCVKRLD GCVYAIKRSK KPLAGSVDEQ NALREVYAHA VLGQHPHVVR 360

YFSAWAEDDH MLIQNEYCNG GSLADAISEN YRIMSYFTEV ELKDLLLQVA RGLRYIHSMS 420

LVHMDIKPSN IFISRTAIPN AASEDGDEDD WISNKVMFKI GDLGHVTRIS SPQVEEGDSR 480

FLANEVLQEN YTHLPKADIF ALALTVVCAA GAEPLPRNGD QWHEIRQGRL PRIPQVLSQE 540

FTELLKVMIH PDPERRPSAM ALIKHSVLLS ASRKSAQQLR IELDAEKFKN SLLQKELKKA 600

QLAKAAAEER ALFTDRMATR STTQSNRTSR LIGKKMNRSV SLTIY 645

Nucleotide Sequence
(FASTA)

ATGAGCTTCC TTAGCCGGCA GCAGCCGCCG CCGCCCCGCC GTGCCGGGGC CGCCTGCACT 60

TTGCGACAGA AGCTGATCTT CTCTCCCTGC AGCGACTGTG AGGAGGAGGA AGAAGAAGAG 120

GAGGAGGAGG GTAGTGGCCA CAGCACTGGA GAGGACTCGG CCTTTCAGGA GCCCGACTCG 180

CCGCTGCCGC CCGCGCGGAG CCCCACGGAG CCCGGGCCAG AGCGCCGCCG CTCGCCCGGC 240

CCGGCCCCCG GCAGCCCCGG GGAACTGGAG GAGGACATGC TGCTGCAGGA CCCCTGCCCG 300

AGCGCGGACG CGGCGGGCGG CGGGGCGGAG GGCGACTCGT GGGAGGAGGA GGGCTTTGGC 360

TCCTCTTCGC CGGTCAAGTC GCCCGCGGCC GCCTACTTCT TAGGCAGCTC TTTCTCGCCT 420

GTGCGCTGCG GCGGCCCGGG GGATGCGTCT CCGCGGGGTT GTGGGGCGCG CCAGTCCGGC 480

GAGGGCCCCT GCTCGCCGTT GCCCGACCAC CCGGGCACCC CGCCGCACAA GACTTTCCGC 540

AAGCTGCGGC TCTTCGACAC GCCGCACACG CCCAAGAGTT TGCTTTCCAA AGCTAGAGGA 600

ATTGATTCCA GCTCTGTGAA ACTCCGCGGT GGTTCTCTAT TCATGGACAC AGAAAAATCA 660

GGAAAGAGAG AATTTGACAC ACGACAGACT CCTCAAGTGA ATATTAATCC TTTTACTCCG 720

GATTCAGTTT TGCTTCATTC CTCAGGACAG TGTCGTAGAA GAAAGAGAGC GTATTGGAAT 780

GATTCCTGTG AAGATATTGA AGGCAGTGAT TATGAGCTTG AAGATGAAAC AAGACCCGCT 840

AAAAGAATTA CAATTACTGA AAGCAATATG AAGTCACGGT ATACGACAGA GTTTCATGAG 900

CTGGAAAAAA TTGGCTCTGG AGAGTTTGGT TCTGTGTTTA AGTGTGTGAA GAGGCTAGAT 960

GGATGCGTTT ATGCCATTAA GCGATCAAAA AAACCATTGG CCGGCTCTGT TGATGAGCAG 1020

AATGCTTTGA GAGAGGTATA TGCTCATGCA GTGCTTGGAC AGCATCCTCA TGTGGTTCGA 1080

TATTTCTCTG CCTGGGCAGA AGATGATCAT ATGCTTATTC AAAATGAATA TTGTAATGGT 1140

GGAAGTTTAG CTGATGCTAT AAGTGAAAAC TACAGAATCA TGAGTTACTT TACAGAAGTA 1200

GAGTTGAAGG ATCTCCTTTT GCAAGTTGCC CGGGGCTTGA GATATATTCA TTCAATGTCT 1260

TTGGTTCACA TGGATATAAA ACCTAGTAAT ATTTTCATAT CTCGAACTGC AATCCCAAAT 1320

GCTGCCTCTG AAGATGGAGA TGAAGATGAC TGGATATCCA ACAAAGTTAT GTTTAAAATA 1380

GGTGATCTTG GGCATGTAAC AAGAATCTCT AGTCCACAAG TTGAAGAAGG TGATAGTCGT 1440

TTTCTTGCAA ATGAAGTTTT ACAGGAGAAC TATACCCATC TACCAAAAGC GGATATTTTT 1500

GCCCTTGCCC TCACAGTGGT GTGTGCTGCT GGTGCTGAAC CTCTTCCCAG AAATGGAGAC 1560

CAATGGCATG AAATCAGACA GGGTAGATTA CCTCGAATTC CCCAAGTGCT TTCCCAGGAA 1620

TTTACAGAGT TGTTAAAAGT TATGATTCAT CCAGATCCAG AGAGAAGACC TTCAGCAATG 1680

GCACTGATAA AGCATTCAGT ATTATTGTCT GCATCTAGAA AGAGTGCCCA ACAATTACGA 1740

ATAGAATTGG ATGCTGAAAA GTTCAAAAAT TCACTTTTGC AGAAAGAACT CAAGAAAGCC 1800

CAGCTGGCAA AAGCTGCAGC TGAGGAAAGA GCACTCTTCA CTGACCGGAT GGCCACTAGG 1860

TCCACCACCC AGAGTAATAG AACCTCTCGA CTTATTGGAA AGAAAATGAA CCGCTCTGTC 1920

AGCCTTACTA TATACTGA 1938

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+e+ekiG+Gefg+vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 298   FHELEKIGSGEFGSVFKCVKRLDGCVYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPH  357

         99**********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++a++e+++++++++e elk++ll++ +glry+H

Q: 358   VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFTEVELKDLLLQVARGLRYIH  417

         ************************************************************

S: 121   ssslvHlDikpenifi...................tkevtlklgDlGlvtelnsedkskv  161

         s+slvH+Dikp+nifi                   +++v++k+gDlG+vt++   ++++v

Q: 418   SMSLVHMDIKPSNIFIsrtaipnaasedgdeddwiSNKVMFKIGDLGHVTRI---SSPQV  474

         ****************************************************...9****

S: 162   eEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdei  220

         eEGDsr+la+E+lqe+y++l kaDiF+l+lt++++a++++lP+nG++Wh++R+g+lp +i

Q: 475   EEGDSRFLANEVLQENYTHLpKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLP-RI  533

         *********************************************************.**

S: 221   lkelsedlrellklmlepdperRptaeellkhevl  255

          ++ls++++ellk+m++pdperRp+a++l+kh+vl

Q: 534   PQVLSQEFTELLKVMIHPDPERRPSAMALIKHSVL  568

         ********************************986

Domain Sequence
(FASTA)

FHELEKIGSG EFGSVFKCVK RLDGCVYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHPH 60

VVRYFSAWAE DDHMLIQNEY CNGGSLADAI SENYRIMSYF TEVELKDLLL QVARGLRYIH 120

SMSLVHMDIK PSNIFISRTA IPNAASEDGD EDDWISNKVM FKIGDLGHVT RISSPQVEEG 180

DSRFLANEVL QENYTHLPKA DIFALALTVV CAAGAEPLPR NGDQWHEIRQ GRLPRIPQVL 240

SQEFTELLKV MIHPDPERRP SAMALIKHSV L 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013