EKS-ICT-00360

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00360

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	314.5	5.1E-94	36	283	248

Status

Unreviewed

Ensembl Protein

ENSSTOP00000008961

UniProt Accession

I3MEL7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K7

Gene Synonyms/Alias

MAP3K7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000009986	ENSSTOP00000008961	ENSSTOT00000009990

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

580

Protein Sequence
(FASTA)

MSTASAASSS SSSSASEMIE TPSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 60

AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 120

PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 180

DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 240

WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 300

PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 360

SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTEGNGQPR RRSIQDLTVT 420

GTEPGQVSSR SSSPSVRMIT TSGPTSEKPT RSHPWTPDDS TDTNGSDNSI PMAYLTLDHQ 480

LQPLAPCPNS KESMAVFEQH CKMAQEYMKV QTEIALLLQR KQELVAELDQ DEKDQQNTSR 540

LVQEHKKLLD ENKSLSTYYQ QCKKQLEVIR SQQQKRQGTS 580

Nucleotide Sequence
(FASTA)

ATGTCTACAG CCTCCGCCGC CTCCTCCTCC TCCTCGTCTT CGGCCAGTGA GATGATCGAG 60

ACCCCTTCCC AGGTCCTTAA CTTTGAAGAG ATCGACTACA AGGAAATCGA GGTGGAAGAG 120

GTTGTTGGAA GAGGAGCATT TGGAGTAGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 180

GCTATTAAAC AAATAGAAAG TGAATCTGAG AGGAAAGCTT TTATTGTAGA GCTTCGGCAG 240

TTATCCCGTG TGAACCATCC TAATATTGTA AAGTTGTATG GAGCCTGCTT GAATCCAGTG 300

TGTCTTGTGA TGGAATATGC TGAAGGAGGC TCTTTATATA ATGTGCTTCA TGGTGCTGAA 360

CCATTGCCAT ATTACACTGC TGCCCATGCA ATGAGTTGGT GTTTACAGTG TTCCCAAGGA 420

GTGGCTTATC TACACAGCAT GCAACCCAAA GCTCTAATTC ACAGGGACCT GAAACCTCCA 480

AACTTGCTGC TGGTTGCAGG GGGGACAGTT CTAAAAATCT GTGATTTTGG TACAGCCTGT 540

GACATTCAGA CACACATGAC CAATAACAAG GGAAGTGCTG CTTGGATGGC ACCTGAAGTT 600

TTTGAAGGTA GCAATTACAG TGAAAAATGT GATGTCTTCA GCTGGGGTAT TATTCTTTGG 660

GAAGTGATAA CACGTCGGAA ACCTTTTGAT GAGATTGGTG GCCCAGCTTT CCGAATTATG 720

TGGGCTGTTC ATAATGGTAC TCGACCACCA CTGATCAAAA ATTTACCTAA GCCCATTGAA 780

AGCCTGATGA CTCGTTGTTG GTCTAAAGAT CCTTCTCAGC GCCCTTCCAT GGAGGAAATT 840

GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CAGATGAGCC ATTACAGTAT 900

CCTTGTCAGT ATTCAGATGA AGGACAGAGC AACTCTGCCA CTAGTACAGG CTCATTCATG 960

GACATTGCTT CTACAAATAC TAGTAATAAA AGTGACACTA ATATGGAGCA AGTTCCTGCC 1020

ACAAATGATA CTATTAAACG CTTAGAATCA AAATTATTGA AAAATCAAGC AAAGCAACAG 1080

AGTGAATCTG GACGTTTAAG CCTGGGAGCC TCCCGTGGGA GCAGTGTGGA GAGTTTGCCC 1140

CCAACCTCCG AGGGCAAGAG GATGAGTGCT GACATGTCGG AAATAGAAGC CAGGATTGCT 1200

GCCACCACAG AAGGCAACGG GCAACCAAGA CGTAGATCCA TCCAAGACTT GACTGTTACT 1260

GGAACAGAGC CTGGTCAGGT GAGCAGTAGG TCATCCAGTC CTAGTGTCAG AATGATCACT 1320

ACCTCAGGAC CAACCTCAGA AAAGCCAACT CGAAGTCATC CATGGACCCC TGATGATTCC 1380

ACAGATACCA ATGGATCAGA TAACTCCATC CCAATGGCTT ATCTTACACT GGATCACCAA 1440

CTACAGCCTC TAGCACCATG CCCAAACTCC AAAGAATCCA TGGCAGTGTT TGAACAGCAT 1500

TGTAAAATGG CACAAGAATA TATGAAAGTT CAAACAGAAA TTGCATTGTT ATTACAGAGA 1560

AAGCAAGAAC TAGTTGCAGA ATTGGACCAG GATGAAAAGG ACCAGCAAAA TACGTCTCGC 1620

CTGGTACAGG AACATAAAAA GCTTTTAGAT GAAAACAAAA GCCTTTCTAC TTACTACCAG 1680

CAATGCAAAA AACAACTAGA GGTCATCAGA AGTCAACAGC AAAAACGACA AGGCACTTCA 1740

TGA 1743

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+gafg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++

Q: 36    IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVK  91

         5789****************************9888....********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G+cl++  ++lvmey+eggsL+nvlh+ +  + ++ ++++sw+lq+++G+aYLhs++p

Q: 92    LYGACLNP--VCLVMEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP  149

         *******9..89*****************778899*************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 150   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  208

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw

Q: 209   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCW  267

         **********************9987447889999.99**********************

S: 238   nedpekRpsfseivks  253

         ++dp++Rps++eivk+

Q: 268   SKDPSQRPSMEEIVKI  283

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG AFGVVCKAKW RAKDVAIKQI ESESERKAFI VELRQLSRVN HPNIVKLYGA 60

CLNPVCLVME YAEGGSLYNV LHGAEPLPYY TAAHAMSWCL QCSQGVAYLH SMQPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHN GTRPPLIKNL PKPIESLMTR CWSKDPSQRP 240

SMEEIVKI 248

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013