EKS-ICT-00218

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00218

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	336.9	8.4E-101	168	419	252

Status

Unreviewed

Ensembl Protein

ENSSTOP00000009264

UniProt Accession

I3MFA0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000010318	ENSSTOP00000009264	ENSSTOT00000010324

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

448

Protein Sequence
(FASTA)

MLWLALGPFR AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

KVNTRAGPSQ HTSPAISDSL PSNSLKKSSA ELKKILATGQ INEQDIRYRD TLGHGNGGTV 180

YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240

TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 300

DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360

KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 420

QFNDGNATVV SMWVCRALEE RRNQQGPP 448

Nucleotide Sequence
(FASTA)

ATGCTGTGGC TGGCCCTTGG CCCCTTCCGT GCCATGGAGA ACCAGGTGTT GGTGATTCGC 60

ATCAAGATTC CAAATAGTGG CGCGGTGGAC TGGACAGTGC ACTCTGGGCC GCAGTTACTC 120

TTCAGAGATG TGCTGGATGT GATAGGCCAG GTTTTGCCTG AAGCAACAAC TACAGCATTT 180

GAATATGAAG ATGAAGATGG TGATAGAATT ACAGTGAGAA GTGATGAAGA AATGAAGGCA 240

ATGCTGTCAT ATTATTATTC CACAGTAATG GAACAGCAAG TAAATGGACA GTTAATAGAG 300

CCTCTGCAGA TATTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 360

AAGGTTAACA CCCGGGCTGG ACCCTCTCAA CACACCAGCC CTGCAATCTC AGATTCACTT 420

CCAAGCAATA GCTTGAAGAA GTCTTCTGCT GAACTGAAAA AAATATTAGC CACTGGGCAG 480

ATAAATGAAC AAGACATACG GTATCGAGAC ACCCTTGGTC ATGGCAACGG AGGCACAGTC 540

TACAAAGCAT ATCATGTTCC AAGTGGGAAA ATATTAGCTG TGAAGGTAAT ACTACTAGAT 600

ATTACGCTGG AACTTCAGAA GCAAATTATG TCTGAATTAG AAATTCTTTA TAAGTGTGAT 660

TCATCATATA TCATAGGATT TTATGGGGCA TTTTTTGTAG AAAACAGGAT TTCAATATGT 720

ACTGAATTTA TGGATGGGGG ATCTTTGGAT GTATATAGGA AAATTCCAGA ACATGTCCTT 780

GGAAGAATTG CAGTAGCAGT TGTTAAAGGC CTTACCTATT TGTGGAGTTT AAAGATTTTA 840

CACAGAGATG TGAAGCCCTC CAACATGCTA GTAAACACAA GAGGCCAGGT CAAGCTGTGT 900

GACTTTGGAG TGAGCACTCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 960

GCTTATATGG CGCCTGAAAG AATTTCAGGG GAGCAGTATG GAATACACTC TGATGTCTGG 1020

AGCTTAGGAA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGATTCAG 1080

AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTTCTGCAGT GCATTGTTGA TGAGGATTCG 1140

CCCGTCCTTC CGGTTGGAGA GTTCTCCGAG CCATTTGTAC ATTTCATCAC TCAGTGCATG 1200

CGAAAACAGC CAAAAGAAAG GCCAGCACCT GAGGAATTGA TGGGCCACCC GTTCATCGTG 1260

CAGTTCAATG ATGGAAATGC CACAGTGGTG TCCATGTGGG TGTGCAGGGC TCTGGAGGAG 1320

AGGCGGAACC AGCAGGGGCC CCCATGA 1347

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 168   YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  226

         5679************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+iavavvk+l+yl+ +l

Q: 227   FYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAVAVVKGLTYLW-SL  277

         ************************.6876.......9********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 278   KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  336

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv  236

         sdvWslG++++ela gr+py++ ++      +l+ll++iv+e++p+lp  efse f++f+

Q: 337   SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPVGEFSEPFVHFI  396

         ***********************9999*********************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C++k++keRp  +el+ h+fi

Q: 397   TQCMRKQPKERPAPEELMGHPFI  419

         **********************7

Domain Sequence
(FASTA)

YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYRKIPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS 120

NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMRKQPKER 240

PAPEELMGHP FI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013