EKS-ICT-00352

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00352

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	421.9	7.5E-127	79	332	254

Status

Unreviewed

Ensembl Protein

ENSSTOP00000009336

UniProt Accession

I3MFE8;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000010404	ENSSTOP00000009336	ENSSTOT00000010403

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

350

Protein Sequence
(FASTA)

VLDEGVVKHY RIRTLDQGGF FLTRRKTFST LNEFVNYYTT TSDGLCVKLE KPCLKIQVPT 60

PFDLSYKTVD QWEIDRNSVQ LLKRLGSGQF GEVWEGLWNN TTPVAVKTLK PGSMDPNDFL 120

REAQIMKSLR HPKLIQLYAV CTLEDPIYII TELMRHGSLQ EYLQNDAGSR IHLPQQVDMA 180

AQVASGMAYL ESQNYIHRDL AARNVLVGEH NIYKVADFGL ARVFKVDNED IYESKHEIKL 240

PVKWTAPEAI RTNKFSIKSD VWSFGILLYE IITYGKMPYS GMTGTQVIQL LGQNYRLPQP 300

SNCPQQFYNI MLECWNAEPK ERPTFETLHW KLEDYFETES SYSDTNNFIR 350

Nucleotide Sequence
(FASTA)

GTTTTAGATG AAGGAGTTGT GAAACACTAC AGAATCAGGA CACTAGACCA AGGGGGCTTT 60

TTCCTTACCC GGAGAAAAAC TTTCTCAACA CTGAATGAAT TCGTGAACTA CTACACCACC 120

ACAAGTGATG GCCTGTGTGT CAAGCTGGAG AAACCATGCT TAAAGATACA AGTCCCAACT 180

CCTTTTGATT TGTCCTATAA AACCGTGGAC CAGTGGGAGA TAGACCGCAA CTCTGTCCAA 240

CTTCTGAAGC GATTGGGATC CGGTCAGTTT GGAGAAGTTT GGGAAGGCCT CTGGAACAAC 300

ACTACTCCAG TGGCTGTAAA GACGTTAAAA CCAGGTTCAA TGGATCCAAA TGACTTCCTG 360

AGGGAGGCAC AGATAATGAA GAGTCTAAGA CATCCAAAGC TTATCCAGCT TTATGCTGTT 420

TGCACTTTAG AAGATCCAAT TTATATTATT ACAGAGTTGA TGAGACATGG AAGTCTGCAA 480

GAATATCTCC AAAATGATGC TGGATCAAGA ATCCATCTGC CTCAACAGGT AGACATGGCG 540

GCACAGGTTG CTTCTGGAAT GGCCTATCTG GAGTCCCAGA ACTATATCCA CAGAGATCTG 600

GCTGCCAGAA ATGTCCTTGT TGGTGAGCAT AATATCTACA AAGTAGCAGA TTTTGGACTG 660

GCAAGAGTTT TTAAGGTAGA TAATGAAGAC ATCTATGAAT CTAAACACGA AATAAAGCTG 720

CCGGTGAAGT GGACTGCACC TGAAGCCATT CGTACTAATA AATTCAGCAT TAAGTCCGAT 780

GTGTGGTCAT TTGGAATCCT TCTTTATGAA ATCATTACTT ATGGCAAAAT GCCGTATAGT 840

GGTATGACAG GTACTCAAGT AATCCAGTTG TTGGGACAAA ACTATAGACT TCCACAGCCA 900

TCTAACTGTC CACAGCAATT CTACAACATC ATGTTGGAGT GCTGGAATGC AGAGCCTAAG 960

GAACGACCAA CATTTGAGAC ACTGCATTGG AAACTTGAGG ACTATTTTGA AACAGAGTCT 1020

TCATATTCAG ATACAAATAA CTTCATAAGA TGA 1053

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 79    VQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLY  138

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g++++lp++vd+aaqva+Gmayle++n+ihr

Q: 139   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSRIHLPQQVDMAAQVASGMAYLESQNYIHR  198

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik

Q: 199   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRTNKFSIK  258

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++ + ++yrlp+p++cp+++y+++lecw+++

Q: 259   SDVWSFGILLYEIITYGKMPYSGMTGTQVIQLLGQNYRLPQPSNCPQQFYNIMLECWNAE  318

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl+++l

Q: 319   PKERPTFETLHWKL  332

         **********9986

Domain Sequence
(FASTA)

VQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SRIHLPQQVD MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGTQVI QLLGQNYRLP QPSNCPQQFY NIMLECWNAE 240

PKERPTFETL HWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013