EKS-ICT-00185

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00185

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	412.4	7.0E-124	61	309	249

Status

Unreviewed

Ensembl Protein

ENSSTOP00000009585

UniProt Accession

I3MFY3;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000010678	ENSSTOP00000009585	ENSSTOT00000010678
ENSSTOG00000010678	ENSSTOP00000016777	ENSSTOT00000023387

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

543

Protein Sequence
(FASTA)

MDRSKWNSIA GFPQRCKRLE EFEGGGGGDG NMTQVGRVWP SSYRALISAF SRLTRLDDFT 60

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRYLGVC 120

VHEGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 180

NCLIKRDENG YSAVVADFGL AEKIPDASMG NEKLAVVGSP FWMAPEVLRD EPYNEKADVF 240

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 300

SFVEIEKTLE EIMNRLQEEE LERDKKLQPT AKGPLEKVPS GKRLSSLDDK IPHKSPRPRR 360

TIWLSRSQSD IFSRKPPRTV SVLDPYYRPP RDGATRTPKV NPFSARQDLK GGKIKLFDLP 420

SKSVISLVFD LDAPGPRTTP LADWQEPLAP PARRWRSLPG SPEFLHQEAC PFVCHEESLS 480

DGPPPRLSSL KYRVREIPPF RAAAPAHEAM DCSIPQEENG FGLKPQETSP CCRSASEEME 540

VEE 543

Nucleotide Sequence
(FASTA)

ATGGATCGGA GCAAATGGAA TTCAATTGCA GGATTTCCCC AACGTTGTAA ACGTCTTGAA 60

GAGTTTGAAG GTGGTGGTGG AGGGGATGGA AACATGACTC AGGTGGGAAG AGTTTGGCCA 120

TCCTCATACA GAGCTCTTAT AAGTGCCTTT TCCAGACTGA CTCGTTTGGA TGACTTCACC 180

TGTGAAAAAA TAGGGTCTGG TTTCTTTTCT GAAGTGTTCA AGGTACGCCA CCGAGCTTCT 240

GGTCAGGTGA TGGCTCTCAA GATGAACACA TTAAGCAGTA ACCGGGCAAA TATGCTGAAA 300

GAAGTACAGC TCATGAATAG ACTTTCCCAC CCCAACATTC TTAGGTATTT GGGTGTATGT 360

GTACATGAAG GACAGTTGCA TGCACTTACA GAGTATATCA ACTCTGGGAA CTTGGAACAG 420

TTGCTAGACA GTAACTTGCA TTTGCCCTGG ACTGTGAGGG TGAAACTGGC CTATGACATA 480

GCAGTGGGCC TCAGCTACCT TCACTTCAAA GGCATTTTCC ATCGGGACCT CACATCAAAG 540

AACTGCCTGA TAAAGAGAGA TGAGAATGGT TATTCTGCAG TGGTGGCTGA CTTTGGCCTA 600

GCTGAGAAGA TTCCTGATGC CAGCATGGGA AATGAGAAGC TGGCTGTGGT GGGATCACCC 660

TTCTGGATGG CACCCGAGGT TCTCCGAGAT GAGCCCTATA ATGAGAAGGC AGACGTGTTC 720

TCTTATGGCA TCATCCTCTG CGAAATCATC GCCCGCATCC AGGCTGATCC AGACTATCTT 780

CCCCGCACAG AGAATTTCGG GCTGGACTAT GACGCTTTCC AGCACATGGT GGGAGACTGT 840

CCCCCAGACT TTCTGCAGCT CACCTTCAAC TGCTGTAATA TGGACCCCAA ACTGCGTCCA 900

TCCTTTGTGG AGATTGAGAA GACCCTGGAG GAAATTATGA ACCGCCTACA GGAAGAAGAG 960

CTGGAGAGGG ACAAGAAGCT GCAACCCACA GCAAAGGGAC CCTTAGAGAA AGTGCCTTCG 1020

GGGAAGAGGC TGAGCTCACT GGATGACAAG ATCCCCCACA AGTCACCACG TCCAAGACGT 1080

ACTATTTGGC TGTCTCGAAG CCAGTCAGAC ATCTTTTCTC GTAAACCCCC ACGTACAGTG 1140

AGTGTCTTGG ACCCCTATTA CCGGCCACCA AGAGATGGTG CTACCCGTAC CCCCAAAGTC 1200

AACCCTTTCA GTGCTCGTCA GGACCTCAAG GGCGGCAAGA TCAAGCTCTT TGACCTACCC 1260

AGCAAGTCTG TAATCTCCCT GGTATTTGAC CTGGATGCAC CAGGGCCTAG AACTACACCC 1320

CTAGCTGACT GGCAAGAGCC CTTGGCCCCA CCTGCTCGCC GATGGCGCTC TTTGCCTGGT 1380

TCACCAGAGT TCTTGCATCA GGAGGCCTGT CCATTTGTGT GCCATGAAGA ATCATTATCT 1440

GATGGGCCCC CACCACGACT CAGTAGTCTC AAGTACAGGG TAAGAGAGAT CCCGCCATTC 1500

CGGGCAGCTG CTCCAGCCCA TGAGGCCATG GACTGCTCTA TTCCCCAGGA AGAAAACGGT 1560

TTTGGGCTCA AGCCCCAGGA GACAAGCCCA TGTTGCAGAA GTGCCTCTGA GGAAATGGAG 1620

GTAGAAGAA 1629

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+n+lkev+l+++l+hpn+l+++G

Q: 61    CEKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRYLG  118

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi++G+l++ll+s+ +lpwt+rv+la+dia+Glsylh+kgi+hrdl+

Q: 119   VCVHEGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT  178

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s+vvadfGla          ek+++++++  +++l+vvGsP+wmaPe

Q: 179   SKNCLIKRdenGYSAVVADFGLA----------EKIPDASMG--NEKLAVVGSPFWMAPE  226

         *******9887899*********..........9****9988..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f

Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPPDF  284

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekkl  265

         l+l+++cc++dp+ rpsf+e+ek+l

Q: 285   LQLTFNCCNMDPKLRPSFVEIEKTL  309

         **********************986

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRYLGVC 60

VHEGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 120

NCLIKRDENG YSAVVADFGL AEKIPDASMG NEKLAVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 240

SFVEIEKTL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013