EKS-ICT-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	293.9	1.1E-87	2	221	220

Status

Unreviewed

Ensembl Protein

ENSSTOP00000009642

UniProt Accession

I3MG17;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K2

Gene Synonyms/Alias

MAP4K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000010732	ENSSTOP00000009642	ENSSTOT00000010743

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

769

Protein Sequence
(FASTA)

GDDISSLQQE ITILRECRHP NVVAYIGSYL RNDRLWICME FCGGGSLQEI YHATGPLEER 60

QIAYVCREAL KGLHHLHSQG KIHRDIKGAN LLLTLQGDVK LADFGVSGEL TASVAKRKSF 120

IGTPYWMAPE VAAVERKGGY NELCDVWALG ITAIELGELQ PPLFHLHPMR ALMLMSKSSF 180

QPPKLRDKTR WTQNFHHFLK LALTKNPKKR PTAEKLLQHP FTTQHLPRAL LTQLLDKASD 240

PHLGTPSPED CELETYDIFP DTIHSRGQHG PAERTPSEIQ FHQVKFGAPR RKETDPLNEP 300

WEEEWTLLGK EELSGSLLQS VQEALEERSL TIRPASELQE LDSPDNAMGT IKRAPFLGLP 360

PTEPTAGNHC GLCAGTLAPA PPGPGSPPLL PTAWATMKQR EDPERSSCHG LPPTPKVHMG 420

ACFSKVFNGC PLRIHAAVTW IHPVTRDQFL VVGAEEGIYT LNLHELHEDT LEKLISHRCS 480

WLYCVNNVLL SLSGKSTHIW AHDLPGLFEQ RRLQQQAPLS IPANRLTQRI IPRRFALSTK 540

IPDTKGCLQC RVVRNPYTGA TFLLAALPAS LLLLQWYEPL QKFLLLKNFS SPLPSPAAML 600

EPLVLEGKEL PQVCVGAEGP AGPGCRVLFH ILPLEAGLTP DILIPPEGIP GPAQQVIQVD 660

RDTVLVSFER CVRIVNLQGE PTATLAPELT FDFPIETVVC LQDSVLAFWS HGMQGRSLDT 720

NEVTQEITDE TRIFRVLGAH RDIILESIPT DNPGAHSNLY ILTGHQNSY 769

Nucleotide Sequence
(FASTA)

GGGGACGACA TCAGTTCCCT CCAGCAGGAA ATCACCATCC TTCGTGAGTG CCGCCACCCC 60

AATGTGGTGG CCTACATTGG CAGCTACCTC AGGAATGACC GCTTGTGGAT CTGCATGGAG 120

TTCTGCGGAG GGGGGTCTCT GCAGGAGATT TACCACGCCA CTGGGCCCCT AGAAGAACGG 180

CAGATTGCGT ATGTCTGCCG AGAGGCACTG AAGGGACTCC ACCACTTGCA TTCTCAGGGG 240

AAGATCCACA GAGACATCAA GGGAGCCAAC CTTCTCCTCA CTCTCCAGGG AGATGTCAAG 300

CTGGCTGACT TCGGGGTGTC GGGCGAGCTG ACGGCATCTG TGGCCAAGAG GAAGTCTTTC 360

ATTGGGACTC CATACTGGAT GGCTCCGGAG GTGGCGGCGG TGGAGCGCAA GGGTGGCTAC 420

AATGAGCTGT GTGATGTCTG GGCCCTGGGC ATCACTGCCA TTGAGCTGGG CGAGCTGCAG 480

CCGCCCCTCT TCCATCTGCA CCCCATGAGG GCCTTGATGC TCATGTCAAA GAGCAGCTTT 540

CAGCCACCCA AGCTGAGAGA CAAGACACGC TGGACCCAGA ATTTCCACCA CTTCCTCAAA 600

CTGGCCTTAA CCAAGAACCC CAAGAAGAGG CCAACGGCTG AGAAGCTTCT GCAGCACCCA 660

TTCACAACCC AGCACCTCCC ACGGGCCCTC CTCACACAGC TCCTGGACAA GGCCAGTGAC 720

CCCCACCTGG GAACCCCCTC CCCTGAGGAC TGTGAGCTGG AGACCTATGA CATTTTCCCA 780

GACACCATCC ACTCCCGGGG GCAGCACGGC CCTGCTGAGA GGACCCCCTC CGAGATCCAG 840

TTTCACCAGG TGAAATTTGG TGCCCCACGC AGGAAGGAGA CGGACCCCCT GAATGAGCCG 900

TGGGAGGAAG AGTGGACGCT GCTGGGAAAG GAGGAGCTGA GTGGGAGCCT GCTACAGTCA 960

GTCCAGGAGG CCCTGGAGGA AAGAAGCCTG ACCATTCGGC CAGCCTCGGA GCTCCAGGAG 1020

CTGGACTCCC CAGATAATGC CATGGGAACC ATCAAGCGGG CTCCGTTCTT GGGGCTGCCC 1080

CCCACTGAGC CCACAGCTGG AAATCACTGT GGCCTGTGCG CAGGAACCCT GGCCCCAGCT 1140

CCCCCTGGCC CTGGCAGCCC GCCACTCCTG CCCACTGCCT GGGCCACCAT GAAGCAGCGA 1200

GAAGATCCTG AGAGGTCATC CTGCCATGGT CTCCCCCCGA CCCCCAAGGT GCACATGGGT 1260

GCCTGCTTCT CCAAGGTCTT CAATGGCTGC CCCTTGCGGA TCCATGCTGC TGTCACCTGG 1320

ATTCACCCCG TTACTCGAGA CCAGTTCCTG GTGGTGGGGG CCGAGGAAGG CATCTATACC 1380

CTCAACCTGC ACGAACTGCA CGAGGACACG CTGGAGAAGC TCATCTCGCA CCGCTGCTCC 1440

TGGCTCTACT GCGTGAACAA TGTGCTGCTG TCACTCTCAG GGAAATCCAC GCACATCTGG 1500

GCGCATGACC TCCCGGGCCT GTTTGAGCAG CGGAGACTCC AGCAGCAGGC CCCCCTCTCC 1560

ATCCCCGCCA ACCGCCTCAC CCAGCGCATC ATTCCCAGGC GCTTTGCCCT ATCTACCAAG 1620

ATTCCTGACA CCAAAGGCTG CCTGCAGTGT CGTGTGGTGC GGAACCCCTA CACGGGCGCC 1680

ACCTTCCTGC TGGCCGCCTT ACCCGCCAGC CTGCTCCTGC TGCAGTGGTA TGAGCCGCTG 1740

CAGAAGTTCC TGCTGCTGAA GAACTTCTCC AGCCCCCTGC CCAGCCCTGC TGCGATGCTG 1800

GAGCCCTTGG TGCTGGAAGG GAAGGAGTTG CCGCAGGTGT GTGTGGGAGC TGAGGGGCCC 1860

GCGGGGCCTG GCTGCCGCGT CCTTTTCCAC ATTCTGCCCC TGGAGGCTGG CCTGACCCCT 1920

GACATCCTCA TCCCACCTGA GGGGATCCCA GGCCCAGCCC AGCAGGTGAT CCAGGTGGAC 1980

AGGGATACAG TCCTGGTCAG CTTTGAACGC TGCGTGAGGA TCGTCAACCT GCAGGGCGAG 2040

CCCACGGCCA CCCTGGCTCC TGAGCTGACT TTTGACTTTC CCATCGAGAC TGTGGTGTGC 2100

CTGCAGGACA GCGTGCTGGC CTTCTGGAGC CATGGCATGC AAGGCCGCAG CCTGGACACC 2160

AACGAGGTGA CCCAGGAGAT CACAGATGAG ACAAGGATCT TCCGAGTCCT GGGGGCCCAC 2220

AGAGACATCA TCCTGGAGAG CATCCCCACT GACAACCCAG GGGCACACAG CAACCTGTAC 2280

ATCCTCACCG GCCACCAGAA CAGCTACTGA 2310

Domain Profile

S: 38    ekleelqkeisvlkklkhpniveylesflkeeelwlvmeylagGslsdlvkeelkselkE  97

         +++++lq+ei++l++++hpn+v+y++s+l++++lw++me++ gGsl+++++   + +l+E

Q: 2     DDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYH--ATGPLEE  59

         56789**********************************************..9******

S: 98    eqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrkt  157

         +qiay++re+lk+L++lHs+++iHrdik++n+Llt +g+VkL+dfgv+ +l+++++krk+

Q: 60    RQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRKS  119

         ************************************************************

S: 158   vvgtpywmAPEviaqe.ekgYdekaDiwslGItaielaegepPfkdleplkallkilkne  216

         ++gtpywmAPEv a+e + gY+e +D+w+lGItaiel e +pP+++l+p++al++++k++

Q: 120   FIGTPYWMAPEVAAVErKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSS  179

         ***************98889*************************************999

S: 217   ..ppklkskkkfskefkefvekclqknpekRpsasellkhkF  256

           ppkl++k++++++f++f++ +l+knp+kRp+a++ll+h+F

Q: 180   fqPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPF  221

         88***************************************9

Domain Sequence
(FASTA)

DDISSLQQEI TILRECRHPN VVAYIGSYLR NDRLWICMEF CGGGSLQEIY HATGPLEERQ 60

IAYVCREALK GLHHLHSQGK IHRDIKGANL LLTLQGDVKL ADFGVSGELT ASVAKRKSFI 120

GTPYWMAPEV AAVERKGGYN ELCDVWALGI TAIELGELQP PLFHLHPMRA LMLMSKSSFQ 180

PPKLRDKTRW TQNFHHFLKL ALTKNPKKRP TAEKLLQHPF 220

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>