EKS-ICT-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	297.6	6.4E-89	470	678	209

Status

Unreviewed

Ensembl Protein

ENSSTOP00000010091

UniProt Accession

I3MGY8;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000011242	ENSSTOP00000010091	ENSSTOT00000011250

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

729

Protein Sequence
(FASTA)

MGNGSVKPKH SKHPDGHTGN LSTDALRSKV TELERELRRK DAEIQEREYH LKELREQLSR 60

QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASVDK VPLEVHRKTS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRH 420

GSSIAYTGSM SKSTAVGKMK EALARSPDIC MEMRVNHSKL TLKSFKSHIS NHNHVFICLC 480

RLYRTFKDNK YVYMLLEACL GGELWSILRD SRNKREETET LCVVCVCVHG GSIERFRKLL 540

ADLKKSISFI ISDSLIPFQV DFGFAKKIGS GQKTWTFCGT PEYVAPEVIL NKGHDFSVDF 600

WSLGILVYEL LTGNPPFSGV DQMMTYNLIL KGIEKMDFPR KITRRPEDLI RRLCRQNPTE 660

RLGNLKNGIN DIKKHRWLNG FNWEGLKARN LPSPLRRELS GPIDHSYFDK YPPEKGVPPD 720

ELSGWDKDF 729

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCCAAACAT TCCAAGCATC CAGATGGCCA CACCGGGAAC 60

CTCAGCACTG ATGCCCTGCG GAGCAAGGTG ACGGAGCTGG AGAGAGAGCT GAGGAGGAAG 120

GATGCTGAGA TTCAAGAGCG GGAGTACCAT TTGAAGGAGC TGCGGGAACA GCTGTCGAGA 180

CAGACCGTGG CCATTGCTGA GCTCACGGAG GAGCTCCAGA ACAAGTGCAT CCAGCTGAAC 240

AAGCTTCAGG ATGTGGTGCA TATGCAGGGA GGAAGCCCAC TCCAGGCTTC TGTGGATAAA 300

GTGCCTCTTG AGGTCCACCG GAAGACCTCG GGATTGGTCT CTCTCCATAG CAGAAGGGGA 360

GCAAAGGCTG GGGTGTCTGC AGAGCCAACA ACCCGAACCT ATGACCTCAA CAAGCCCCCT 420

GAGTTTTCCT TTGAGAAAGC GAGAGTCAGA AAGGACTCCA GTGAGAAGAA GCTCATTACA 480

GATGCCCTTA ATAAAAACCA GTTCCTGAAG AGACTGGATC CTCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTATGGGAG AAACTACCAG CAAGGCAGTT ACATTATTAA GCAAGGAGAA 600

CCAGGAAACC ATATATTTGT GCTGGCAGAG GGTCGACTAG AGGTGTTCCA AGGAGAGAAA 660

TTGCTATCAT CCATCCCTAT GTGGACCACA TTTGGTGAAC TAGCCATTTT ATACAACTGT 720

ACCAGGACTG CCTCTGTGAA AGCTATTACC AATGTTAAAA CATGGGCATT AGATCGAGAG 780

GTTTTCCAGA ATATAATGCG GAGGACAGCT CAAGCTAGAG ATGAACAGTA CAGAAACTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAATTTA CCAGAAGATA AACTGACCAA GATCATTGAC 900

TGTTTGGAAG TGGAATACTA CGACAAAGGC GATTACATCA TTAGAGAGGG CGAGGAAGGG 960

AGTACCTTTT TCATTTTGGC AAAAGGAAAG GTTAAAGTCA CTCAGAGTAC TGAGGGCCAC 1020

GATCAACCAC AGCTGATTAA AACACTGCAG AAAGGAGAAT ACTTTGGTGA AAAAGCTCTG 1080

ATCAGTGATG ATGTCAGGTC AGCTAACATT ATTGCTGAAG AAAATGATGT CGCTTGCCTG 1140

GTTATAGATC GAGAAACATT CAATCAAACT GTTGGGACAT TTGAAGAACT CCAAAAATAC 1200

CTGGAAGGGT ATGTGGCAAA CCTGAACCGT GATGATGAGA AAAGACATGC CAAAAGACAT 1260

GGGAGCTCCA TTGCCTATAC AGGATCCATG AGCAAAAGCA CAGCAGTAGG AAAGATGAAA 1320

GAAGCTTTGG CAAGAAGCCC AGATATTTGT ATGGAGATGA GGGTCAATCA TTCAAAATTG 1380

ACTTTAAAGA GCTTTAAAAG CCATATTTCT AATCATAACC ATGTTTTTAT CTGTCTTTGC 1440

AGATTATATC GTACTTTTAA GGACAATAAA TATGTGTACA TGCTTCTGGA GGCCTGCTTA 1500

GGTGGGGAGC TATGGAGTAT ATTAAGAGAC AGTAGGAATA AGAGAGAAGA GACAGAGACT 1560

CTGTGTGTGG TGTGTGTGTG TGTGCATGGT GGGAGTATAG AAAGATTTAG GAAGTTACTG 1620

GCAGACTTAA AGAAGAGCAT AAGTTTTATA ATCTCTGACT CTTTGATTCC TTTCCAGGTT 1680

GACTTTGGAT TTGCTAAAAA AATAGGTTCT GGACAGAAAA CGTGGACATT CTGTGGGACT 1740

CCAGAATATG TAGCTCCTGA GGTCATTCTC AACAAAGGGC ATGACTTTAG TGTGGACTTT 1800

TGGTCCCTGG GAATTCTAGT GTATGAGCTC CTAACAGGAA ACCCACCCTT TTCTGGGGTT 1860

GATCAAATGA TGACCTACAA TTTGATTCTC AAAGGAATTG AAAAAATGGA TTTTCCCAGG 1920

AAGATAACAA GAAGACCTGA AGATTTAATT CGCAGGCTTT GCAGGCAAAA TCCAACAGAA 1980

AGACTGGGAA ATCTAAAGAA TGGAATCAAT GACATTAAGA AACACAGGTG GTTAAATGGT 2040

TTTAATTGGG AAGGACTGAA AGCACGGAAT CTCCCCTCAC CCTTACGAAG AGAGCTCAGT 2100

GGACCCATCG ATCACAGCTA CTTTGACAAG TATCCTCCTG AAAAGGGAGT GCCTCCAGAT 2160

GAGCTGTCCG GCTGGGATAA GGACTTCTAA 2190

Domain Profile

S: 55    eeaksdfi..vklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvea  112

          + +  fi  ++lyrtfkd+kyvy+lleaclggelw+ilrd  +  ++t  ++v cv

Q: 470   SNHNHVFIclCRLYRTFKDNKYVYMLLEACLGGELWSILRDSRNKREETETLCVVCVCVH  529

         44444454227**********************************************999

S: 113   leylhskniiyrdlkpe.nllldeegylklvdfgfakklksgkktwtfcgtpeyvapeii  171

            + +   +  dlk    ++++++     vdfgfakk++sg+ktwtfcgtpeyvape+i

Q: 530   GGSIERFRKLLADLKKSiSFIISDSLIPFQVDFGFAKKIGSGQKTWTFCGTPEYVAPEVI  589

         999999999999998762566677777788******************************

S: 172   lnkghdlsvdywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedl  231

         lnkghd+svd+w+lgilvyelltg+ppfsgvd+++tynlilkgi+k+++prkit+++edl

Q: 590   LNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDL  649

         ************************************************************

S: 232   ikklcrdnpaerlgylkggikdikkhkwf  260

         i++lcr+np+erlg+lk+gi+dikkh+w+

Q: 650   IRRLCRQNPTERLGNLKNGINDIKKHRWL  678

         ****************************7

Domain Sequence
(FASTA)

SNHNHVFICL CRLYRTFKDN KYVYMLLEAC LGGELWSILR DSRNKREETE TLCVVCVCVH 60

GGSIERFRKL LADLKKSISF IISDSLIPFQ VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI 120

LNKGHDFSVD FWSLGILVYE LLTGNPPFSG VDQMMTYNLI LKGIEKMDFP RKITRRPEDL 180

IRRLCRQNPT ERLGNLKNGI NDIKKHRWL 209

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR014710	; RmlC-like_jellyroll.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013