EKS-ICT-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR613.71.0E-184593950358
StatusUnreviewed
Ensembl ProteinENSSTOP00000010162
UniProt AccessionI3MH41;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000011314ENSSTOP00000010162ENSSTOT00000011327
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length1089
Protein Sequence
(FASTA)
MGTSHQAFLV FGCLLTGPGL ILCQLSLPSI LPNENEKVVQ LNASFSLRCF GESEVSWQYP 60
MSEEENPNVE IIDEENNSGL FVTVLEVASA SAAHTGLYTC YYNHTQTEES EIEGRHIYIY 120
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVI LRNSEGLVPA SYDSKQGFNG 180
TFSVGPYICE ATVKGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 240
EVVDLQWTYP GEVKGKGVTM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATKEVK 300
EMKKVTISVH EKGFVEIKPT FGQLEAVNLH EVRHFVVDVQ AYPPPRISWL KDNLTLIENL 360
TEITTDVEKI QEIRYRSKLK LIRAKEEDSG HYTIIVQNED DVKSYTFELL TQVPSSILDL 420
VDDHHGSSGG QTVRCTAEGT PLPDIEWMIC KDIKKCNNET SWTVLANNVS NIITEIYPRG 480
KSTVEGRVTF AKVEETIAVR CLAKNLLGSG NRELKLVAPT LRSELTVAAA VLVLLVIVII 540
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSRHPEK PKKELDIFGL NPADESTRSY 720
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 780
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV QCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 960
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080
SDLVEDSFL 1089
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCATCAGGC CTTCCTGGTC TTCGGCTGTC TCCTCACAGG GCCGGGCCTA 60
ATCCTCTGCC AGCTTTCATT ACCCTCCATC CTTCCAAATG AGAATGAAAA GGTTGTGCAG 120
CTGAATGCAT CCTTTTCTCT GCGGTGCTTT GGGGAGAGTG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACCC CAATGTGGAA ATCATAGATG AAGAGAACAA CAGTGGCCTT 240
TTTGTGACAG TGCTGGAAGT GGCCAGTGCC TCGGCGGCCC ACACTGGCTT GTACACTTGC 300
TATTACAACC ACACTCAGAC AGAAGAAAGC GAGATTGAAG GCAGGCACAT TTACATCTAT 360
GTGCCAGACC CGGATGTGGC CTTTGTGCCT CTAGGGATGA CAGATTATTT AGTCATCGTG 420
GAAGATGATG ATTCTGCCAT CATACCCTGC CGTACCACAG ACCCGGAGAC TCCTGTGATC 480
TTACGCAACA GTGAGGGACT GGTGCCTGCC TCTTATGACA GCAAACAGGG CTTCAATGGG 540
ACCTTCAGTG TGGGGCCCTA CATCTGTGAG GCCACCGTAA AAGGGAAGAA GTTCCAGACC 600
ATACCCTTTA ACGTTTATGC TTTGAAAGCA ACATCAGAAC TGGATCTAGA AATGGAGGCT 660
CTGAAAACTG TGTATAAGTC AGGAGAAACG ATCGTGGTTA CCTGCGCTGT TTTTAACAAT 720
GAGGTGGTCG ACCTGCAGTG GACTTACCCT GGAGAAGTGA AAGGCAAAGG AGTCACGATG 780
CTGGAGGAAA TCAAAGTCCC ATCCATCAAA TTGGTGTACA CATTGACGGT CCCTGAGGCC 840
ACGGTGAAAG ACAGTGGAGA TTATGAATGT GCTGCCCGCC AGGCCACCAA GGAGGTCAAA 900
GAAATGAAGA AAGTCACCAT TTCTGTCCAT GAGAAAGGGT TTGTTGAAAT CAAACCCACC 960
TTTGGCCAGC TGGAAGCTGT CAACCTGCAT GAAGTCAGAC ATTTTGTGGT GGACGTGCAG 1020
GCCTACCCCC CTCCCAGGAT ATCTTGGCTG AAGGACAACC TGACTCTGAT TGAAAATCTC 1080
ACTGAGATCA CCACTGATGT GGAAAAGATT CAGGAAATAA GGTATCGAAG CAAATTAAAG 1140
CTGATCCGTG CTAAGGAAGA AGATAGTGGC CATTATACTA TAATAGTTCA AAATGAAGAT 1200
GATGTGAAGA GCTATACTTT TGAACTATTA ACTCAAGTTC CATCCTCTAT TCTGGATTTG 1260
GTCGACGACC ATCATGGCTC CAGCGGAGGA CAGACTGTGA GGTGCACGGC TGAGGGCACA 1320
CCTCTTCCCG ACATTGAGTG GATGATCTGC AAGGATATTA AAAAATGTAA TAATGAAACG 1380
TCATGGACAG TCTTAGCCAA CAATGTCTCA AATATCATCA CGGAGATCTA CCCTCGAGGC 1440
AAGAGTACCG TGGAGGGCCG AGTGACATTT GCCAAAGTAG AGGAGACCAT TGCAGTTCGA 1500
TGCCTGGCTA AGAATCTCCT TGGTTCTGGG AACCGAGAGC TGAAGCTGGT GGCTCCCACC 1560
CTGCGTTCTG AGCTTACGGT GGCAGCCGCA GTCCTGGTGC TGTTGGTGAT TGTGATCATC 1620
TCACTTATTG TCCTGGTTGT CATTTGGAAA CAGAAACCAA GGTATGAAAT TCGCTGGAGG 1680
GTCATTGAAT CAATCAGCCC CGATGGACAT GAATATATTT ATGTGGACCC GATGCAGCTA 1740
CCTTATGACT CGAGATGGGA ATTTCCAAGA GATGGACTAG TGCTTGGTCG CATCTTGGGA 1800
TCTGGTGCAT TTGGGAAAGT GGTTGAAGGA ACAGCCTATG GATTAAGCCG GTCCCAGCCT 1860
GTTATGAAAG TAGCAGTGAA GATGCTCAAA CCGACTGCCA GGTCCAGTGA AAAACAAGCT 1920
CTCATGTCTG AGCTGAAGAT AATGACTCAC CTGGGGCCAC ATTTAAACAT CGTCAACTTG 1980
CTGGGAGCCT GTACTAAGTC AGGCCCCATC TACATCATCA CTGAGTACTG TTTCTATGGG 2040
GATCTGGTCA ACTATTTGCA TAAGAATAGG GATAGCTTCC TGAGCCGCCA CCCAGAGAAG 2100
CCAAAGAAAG AGCTGGACAT CTTTGGATTG AACCCTGCTG ATGAGAGCAC ACGCAGTTAC 2160
GTGATTCTAT CTTTTGAGAA CAATGGTGAT TACATGGACA TGAAGCAAGC CGACACTACA 2220
CAGTACGTCC CCATGTTGGA AAGAAAAGAG GTCTCCAAGT ATTCGGACAT CCAGAGATCA 2280
CTGTACGATC GCCCGGCCTC GTATAAGAAG AAATCTATGT TAGACTCAGA AGTCAAAAAC 2340
CTCCTTTCAG ATGACAACTC AGAAGGCCTT ACTTTGTTGG ATTTGTTGAG CTTCACCTAT 2400
CAAGTTGCCC GAGGAATGGA GTTTTTGGCT TCCAAAAATT GTGTCCACCG GGATCTGGCT 2460
GCTCGCAATG TCCTCCTAGC ACAAGGGAAG ATTGTGAAGA TCTGTGACTT TGGCCTGGCC 2520
AGGGACATCA TGCACGATTC CAACTACGTG TCGAAAGGCA GTACCTTCCT TCCTGTGAAG 2580
TGGATGGCTC CCGAGAGCAT CTTTGACAAC CTCTACACCA CGCTGAGCGA TGTCTGGTCT 2640
TATGGGATTC TGCTCTGGGA GATCTTTTCT CTTGGTGGCA CACCCTACCC TGGCATGATG 2700
GTGGATTCTA CCTTCTACAA TAAGATCAAG AGTGGGTACC GGATGGCCAA GCCTGACCAT 2760
GCCACCAGTG AAGTCTATGA GATCATGGTG CAGTGCTGGA ACAGTGAGCC AGAGAAGAGA 2820
CCCTCCTTCT ACCACCTGAG CGAGATAGTG GAGAATCTTC TGCCTGGACA ATATAAAAAG 2880
AGTTATGAAA AAATTCACCT GGACTTCCTG AAGAGTGACC ATCCCGCTGT GGCACGCATG 2940
CGTGTGGACT CGGACAACGC ATACATTGGT GTCACCTACA AAAATGAGGA AGACAAGCTG 3000
AAGGACTGGG AAGGTGGCCT GGATGAGCAG AGACTGAGCG CAGACAGTGG CTACATCATC 3060
CCTCTGCCTG ACATTGACCC TGTTCCTGAG GAGGAAGACC TGGGCAAGAG GAACAGACAC 3120
AGCTCACAGA CCTCTGAAGA GAGTGCCATT GAGACAGGTT CCAGCAGCTC CACCTTCATC 3180
AAGAGAGAGG ACGAGACCAT TGAGGACATC GACATGATGG ATGACATTGG CATAGACTCC 3240
TCAGACCTGG TGGAGGACAG CTTCCTGTAA 3270
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSRHPEK---PKKELDIFG  709
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 710   LnPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  769
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim++cw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSRHPEKPK KELDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVQC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013