EKS-ICT-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	446.2	3.4E-134	427	687	261

Status

Unreviewed

Ensembl Protein

ENSSTOP00000010617

UniProt Accession

I3MI29;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000011825	ENSSTOP00000010617	ENSSTOT00000011838

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

799

Protein Sequence
(FASTA)

MEEGGSGGVA AGTSGDGGGD SGEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY 60

GKVFLVRKIS GHDAGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA 120

FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHK LGIIYRDIKL 180

ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS 240

LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLTKDPKK 300

RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS 360

PAALPQSSER LFQGYSFVAP SILFKRNAAV IDPLQFHLGV ERPGMANVAR SAMVKDSPFY 420

QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ AFAVKIISKR MEANTQKEIT ALKLCEGHPN 480

IVKLHEVFHD QLHTFLVMEL LNGGELFERI KKKKHFSETE ASYIMRKLVS AVSHMHDVGV 540

VHRDLKPENL LFTDENDNLE IKVIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNHNGYD 600

ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG EAWKNVSQEA 660

KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA VHTCVKATFH 720

AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESCHSSSSHS HGKTTPTKTL 780

QPSNPADSTN PESLFQFSD 799

Nucleotide Sequence
(FASTA)

ATGGAGGAGG GCGGCAGCGG CGGCGTCGCC GCGGGCACCA GCGGGGACGG CGGCGGCGAC 60

AGCGGCGAGC AGCTCCTAAC TGTCAAGCAC GAGCTGCGGA CCGCTAATTT AACAGGACAT 120

GCAGAGAAGG TTGGAATTGA AAATTTTGAG CTCCTGAAGG TTCTAGGAAC TGGAGCTTAT 180

GGAAAAGTAT TTCTAGTGCG TAAAATAAGC GGCCACGATG CTGGAAAGCT GTATGCCATG 240

AAAGTTTTGA AAAAGGCAAC CATCGTTCAG AAGGCCAAAA CGACAGAGCA CACGAGGACA 300

GAACGGCAAG TCCTGGAGCA CATCAGGCAG TCGCCATTCT TGGTGACTCT GCACTATGCT 360

TTCCAGACAG AAACCAAGCT TCATCTCATT TTAGATTATA TAAATGGTGG AGAACTTTTT 420

ACTCATCTTT CTCAAAGAGA GCGTTTCACA GAGCATGAGG TGCAGATCTA TGTTGGAGAG 480

ATTGTACTTG CCCTCGAACA TCTGCATAAG TTGGGGATTA TATACCGTGA CATTAAGCTT 540

GAGAATATTC TACTTGATTC TAATGGCCAT GTGGTGCTGA CAGATTTTGG TCTGAGTAAG 600

GAGTTTGTGG CTGATGAAAC TGAAAGAGCA TATTCCTTTT GCGGAACTAT TGAATACATG 660

GCACCAGATA TTGTCAGAGG GGGCGATTCT GGACACGACA AGGCAGTTGA CTGGTGGAGT 720

TTAGGTGTTC TAATGTATGA ATTACTAACT GGAGCATCTC CTTTCACTGT GGATGGAGAA 780

AAAAATTCCC AGGCTGAAAT ATCTAGGAGG ATATTGAAAA GTGAGCCTCC GTATCCACAG 840

GAGATGAGCG CGTTAGCTAA AGACCTGATT CAGCGTCTTC TGACGAAAGA TCCCAAGAAG 900

AGATTGGGAT GTGGTCCTCG GGATGCAGAT GAAATCAAGG AACATCTCTT CTTTCAGAAA 960

ATCAACTGGG ATGACTTAGC TGCCAAAAAA GTGCCTGCAC CATTTAAGCC AGTCATCCGA 1020

GATGAATTAG ATGTGAGTAA CTTTGCTGAA GAGTTCACAG AAATGGACCC AACCTATTCC 1080

CCGGCAGCCC TGCCCCAGAG CTCCGAGCGG CTGTTCCAGG GCTATTCCTT TGTTGCTCCT 1140

TCTATCCTGT TCAAGCGCAA TGCAGCTGTC ATAGATCCTC TTCAGTTTCA CCTGGGAGTC 1200

GAGCGTCCTG GCATGGCGAA TGTTGCCAGG AGTGCCATGG TGAAGGACTC TCCATTCTAT 1260

CAACACTATG ACCTAGATCT GAAAGACAAA CCATTGGGAG AAGGAAGTTT TTCCATTTGT 1320

AGAAAGTGCG TGCACAAAAA AAGTAACCAA GCATTTGCAG TCAAAATAAT CAGCAAAAGA 1380

ATGGAAGCCA ACACTCAGAA AGAAATAACC GCTCTGAAGC TCTGTGAAGG ACACCCCAAT 1440

ATTGTGAAGC TGCATGAGGT TTTTCATGAT CAGCTTCATA CTTTTCTGGT GATGGAACTT 1500

CTGAATGGGG GAGAACTGTT TGAACGCATA AAGAAGAAGA AGCACTTTAG TGAGACGGAA 1560

GCCAGCTACA TCATGCGGAA GCTCGTGTCG GCTGTCAGCC ACATGCACGA TGTCGGGGTG 1620

GTGCACCGGG ATCTGAAGCC GGAGAATTTA TTGTTCACTG ATGAAAATGA TAATTTGGAA 1680

ATTAAAGTTA TCGATTTCGG GTTTGCTCGC CTCAAGCCGC CTGACAATCA GCCCCTGAAG 1740

ACCCCGTGCT TCACCCTTCA TTACGCAGCC CCGGAGCTCT TGAATCACAA CGGCTACGAT 1800

GAGTCCTGTG ACCTGTGGAG CTTGGGTGTC ATCTTGTATA CAATGTTGTC AGGGCAGGTT 1860

CCATTCCAGT CTCATGACAG AAGTTTGACG TGCACCAGCG CAGTCGAAAT CATGAAGAAA 1920

ATTAAAAAGG GAGATTTCTC CTTTGAAGGA GAAGCCTGGA AGAATGTATC CCAAGAGGCT 1980

AAAGATTTGA TTCAAGGACT TCTCACTGTT GATCCAAATA AAAGACTTAA AATGTCTGGC 2040

TTGAGATACA ATGAATGGCT TCAAGATGGC AGTCAGCTGT CCTCGAATCC TCTGATGACT 2100

CCAGACATTC TGGGATCTTC GGGAGCTGCC GTGCACACCT GTGTGAAAGC AACCTTCCAT 2160

GCCTTTAACA AATACAAGAG AGAAGGATTT TGCCTTCAGA ATGTCGATAA GGCCCCATTG 2220

GCTAAGAGAA GGAAAATGAA AAAGACCAGC ACCAGTACAG AGACCCGCAG CAGCTCCAGC 2280

GAGAGCTGCC ATTCTTCCTC CTCCCATTCC CATGGCAAAA CTACGCCCAC CAAGACCCTG 2340

CAGCCCAGCA ACCCTGCTGA TAGCACTAAC CCAGAGAGCC TCTTCCAGTT CTCGGACTGA 2400

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++cvhk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++

Q: 427   LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  486

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk

Q: 487   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  546

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen+l++de+dn+e ik+idfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 547   PENLLFTDENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNHNGYDESCDL  605

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236

         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++

Q: 606   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  665

         *****************9998899************************************

S: 237   klltvdpakrlkleqllkhswl  258

         +lltvdp+krlk+++l++++wl

Q: 666   GLLTVDPNKRLKMSGLRYNEWL  687

         *********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCVHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60

VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120

PENLLFTDEN DNLEIKVIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNH NGYDESCDLW 180

SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240

LLTVDPNKRL KMSGLRYNEW L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013