EKS-ICT-00140

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00140

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	448.3	5.3E-135	235	478	244

Status

Unreviewed

Ensembl Protein

ENSSTOP00000010669

UniProt Accession

I3MI65;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000011892	ENSSTOP00000010669	ENSSTOT00000011897

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

MAGRTSMVSR LALYGCDSTK EPPRVSSRLL GAWHPPPITV RMPTRRWAPG TQCITKCEHT 60

RPKPGELAFR KGDVVTILEA CENKSWYRAK HHASGQEGLL AAGALREREA LSADPKLSLM 120

PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI 180

DEAVCFCNLM DMVEHYSKDK GAICTKLVRP KRKQGTRSAE EELAKAGWLL DLQHLTLGAQ 240

IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKLQHKNLVR LLGVILHQGL 300

YIVMEHVSKG NLVNFLRTRG RALVNNAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV 360

SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FSSKSDVWSF GVLLWEVFSY 420

GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHALMGSC WEAEPSRRPP FRKVAEKLTR 480

ELRSLGTSAT VGAQDADVST PPRSQEP 507

Nucleotide Sequence
(FASTA)

ATGGCAGGAC GAACCTCCAT GGTCTCCAGG CTGGCATTGT ATGGCTGTGA CTCGACTAAG 60

GAGCCTCCCC GGGTGAGCTC TCGCCTTTTG GGGGCCTGGC ACCCCCCACC CATCACAGTC 120

AGGATGCCGA CCAGGCGCTG GGCCCCGGGC ACTCAGTGCA TCACCAAGTG CGAGCACACG 180

CGCCCCAAGC CGGGGGAGCT GGCCTTCCGC AAGGGCGACG TGGTCACCAT CCTGGAGGCC 240

TGCGAGAACA AGAGCTGGTA CCGAGCCAAG CACCACGCCA GCGGCCAGGA GGGGCTGCTG 300

GCGGCCGGCG CGCTGCGGGA GCGCGAGGCC CTGTCGGCGG ACCCCAAGCT CAGCCTCATG 360

CCGTGGTTCC ACGGGAAGAT CTCGGGCCAG GAGGCGGTGC AGCAGCTGCA GCCCCCCGAG 420

GACGGGCTGT TCCTGGTGCG CGAGTCGGCG CGGCACCCCG GCGACTACGT GCTGTGCGTG 480

AGCTTCGGCC GCGACGTCAT CCACTACCGC GTGCTGCACC GCGACGGGCA CCTCACCATC 540

GATGAGGCCG TCTGCTTCTG CAATCTCATG GACATGGTGG AGCACTACAG CAAGGACAAG 600

GGTGCCATCT GCACGAAGTT GGTGAGGCCC AAGAGGAAGC AGGGCACCCG GTCCGCGGAG 660

GAGGAGCTGG CCAAGGCCGG CTGGCTCCTG GACCTGCAGC ACCTGACGCT GGGGGCGCAG 720

ATCGGAGAGG GAGAGTTTGG AGCTGTCCTG CAGGGCGAGT ACCTGGGGCA GAAGGTGGCC 780

GTGAAGAACA TCAAGTGCGA CGTGACAGCC CAGGCCTTCC TGGACGAGAC CGCGGTCATG 840

ACGAAGCTGC AGCACAAGAA CCTGGTGCGG CTCCTGGGCG TGATCCTGCA CCAGGGGCTC 900

TACATCGTCA TGGAGCACGT GAGCAAGGGC AACCTGGTGA ACTTCCTGCG CACCCGCGGC 960

CGGGCCCTGG TGAACAACGC CCAGCTCCTG CAGTTCTCGC TGCATGTGGC AGAGGGCATG 1020

GAGTACCTGG AGAGCAAGAA GCTGGTGCAC CGAGACCTGG CCGCCCGCAA CATCCTGGTC 1080

TCTGAGGACC TGGTGGCCAA GGTCAGTGAC TTCGGCCTGG CCAAAGCTGA GCGGAAGGGG 1140

CTGGACTCAA GCCGGCTGCC TGTCAAGTGG ACAGCGCCTG AGGCTCTCAA ACATGGGAAG 1200

TTCTCCAGCA AGTCGGACGT CTGGAGTTTT GGGGTGCTGC TGTGGGAGGT CTTCTCATAC 1260

GGACGGGCTC CATACCCCAA GATGTCGCTG AAGGAGGTGT CGGAGGCCGT GGAGAAGGGC 1320

TACCGCATGG AGCCCCCCGA GGGCTGCCCT GGGCCCGTGC ACGCCCTCAT GGGCAGCTGC 1380

TGGGAGGCAG AGCCCTCCCG CCGGCCACCC TTCCGCAAGG TGGCAGAGAA GCTGACCCGG 1440

GAGCTACGCA GTCTGGGCAC CTCGGCCACC GTGGGGGCAC AGGACGCCGA CGTGTCCACT 1500

CCGCCCCGAA GCCAGGAGCC GTGA 1524

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lg++ig+gefg+vl+gey g+kvavk+ik+d+taqaflde++vmtkl+h+nlv+llgv

Q: 235   LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKLQHKNLVRLLGV  294

         6899********************************************************

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         il++ gly+v+e+v+kg+lv++lr+rgral++++qll+f+l+vaegmeyleskklvhrdl

Q: 295   ILHQ-GLYIVMEHVSKGNLVNFLRTRGRALVNNAQLLQFSLHVAEGMEYLESKKLVHRDL  353

         ***9.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarn+lvsedlvakvsdfglak+e+k+lds++lpvkwtapealk++kfs+ksdvwsfg+l

Q: 354   AARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFSSKSDVWSFGVL  413

         ************************************************************

S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240

         lwe+fs+gr+pyp+++lk+v++avekgy+me+pegcp+ v+ lm ++we+e+++rp+f+k

Q: 414   LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHALMGSCWEAEPSRRPPFRK  473

         ************************************************************

S: 241   lkekl  245

         ++ekl

Q: 474   VAEKL  478

         **997

Domain Sequence
(FASTA)

LTLGAQIGEG EFGAVLQGEY LGQKVAVKNI KCDVTAQAFL DETAVMTKLQ HKNLVRLLGV 60

ILHQGLYIVM EHVSKGNLVN FLRTRGRALV NNAQLLQFSL HVAEGMEYLE SKKLVHRDLA 120

ARNILVSEDL VAKVSDFGLA KAERKGLDSS RLPVKWTAPE ALKHGKFSSK SDVWSFGVLL 180

WEVFSYGRAP YPKMSLKEVS EAVEKGYRME PPEGCPGPVH ALMGSCWEAE PSRRPPFRKV 240

AEKL 244

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013