EKS-ICT-00351

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00351

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	433.9	1.7E-130	245	494	250

Status

Unreviewed

Ensembl Protein

ENSSTOP00000010824

UniProt Accession

I3MIH9;

Protein Name

Protein Synonyms/Alias

Gene Name

LCK

Gene Synonyms/Alias

LCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000012070	ENSSTOP00000010824	ENSSTOT00000012071

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MGCTCSSNPE DDWMENIDVC ENCHYPIVPL DGKGTLLMRN GSEVRDPLVT YEGSNPPASP 60

LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120

SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 180

YKIRNLDNGG FYISPRITFP GLHELVRHYT NTSDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240

PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHPRL 300

VRLYAVVTQE PIYIITEYME NGSLVDFLKT SSGIKLTINK LLDMAAQIAE GMAFIEERNY 360

IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420

SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY HLMMLCWKEH 480

PEDRPTFDYL RSVLEDFFTA TEGQYQPQP 509

Nucleotide Sequence
(FASTA)

ATGGGCTGTA CCTGCAGCTC CAACCCTGAA GATGACTGGA TGGAAAACAT CGATGTGTGT 60

GAGAACTGCC ATTATCCCAT AGTCCCACTG GATGGCAAGG GCACGTTGCT CATGAGGAAT 120

GGCTCTGAAG TACGGGACCC ACTTGTCACC TATGAGGGCT CCAACCCACC AGCCTCTCCA 180

CTGCAAGATA ACCTGGTTAT CGCCCTGCAC AGCTATGAGC CCTCTCACGA CGGAGACCTG 240

GGCTTCGAGA AGGGTGAACA GCTCCGTATC CTGGAACAGA GCGGCGAGTG GTGGAAGGCG 300

CAGTCCCTCA CCACAGGCCA GGAAGGTTTC ATCCCTTTCA ACTTCGTGGC CAAAGCGAAC 360

AGTCTGGAAC CCGAACCCTG GTTCTTCAAG AACCTAAGCC GCAAGGACGC TGAGCGGCAG 420

CTCCTGGCGC CCGGGAACAC GCACGGTTCC TTCTTGATCC GAGAAAGCGA GAGCACAGCT 480

GGATCATTTT CACTGTCGGT CCGGGACTTC GACCAGAATC AGGGAGAGGT GGTGAAACAT 540

TACAAGATCC GTAACCTAGA CAACGGCGGG TTCTACATCT CCCCTCGCAT CACTTTTCCC 600

GGATTGCATG AACTGGTCCG CCATTACACC AATACTTCTG ATGGGCTGTG CACTAGGTTG 660

AGCCGCCCCT GCCAGACCCA GAAGCCCCAG AAGCCGTGGT GGGAGGACGA GTGGGAGGTT 720

CCCAGGGAGA CGCTGAAGCT GGTGGAGCGA CTGGGGGCCG GCCAGTTCGG GGAGGTGTGG 780

ATGGGGTACT ACAACGGGCA CACGAAGGTG GCAGTGAAGA GCCTGAAGCA AGGCAGCATG 840

TCCCCTGACG CCTTCCTCGC TGAGGCCAAC CTCATGAAGC AGCTGCAGCA CCCGCGGCTG 900

GTCCGGCTCT ACGCGGTGGT CACCCAGGAG CCAATCTACA TCATCACCGA ATACATGGAG 960

AATGGGAGCC TGGTGGATTT TCTCAAGACC TCCTCAGGCA TCAAATTGAC CATCAACAAA 1020

CTCTTGGACA TGGCAGCCCA AATTGCAGAG GGCATGGCAT TCATTGAAGA GCGGAATTAC 1080

ATCCACCGTG ACCTGCGAGC TGCAAACATC CTGGTGTCTG ACACCCTGAG CTGCAAGATT 1140

GCAGACTTTG GCCTAGCACG GCTCATTGAG GACAATGAGT ACACAGCCAG GGAGGGGGCC 1200

AAATTTCCCA TTAAGTGGAC AGCACCAGAG GCCATCAACT ACGGGACATT CACCATCAAG 1260

TCAGATGTGT GGTCTTTCGG AATTCTATTG ACGGAAATTG TTACCCATGG CCGTATCCCT 1320

TACCCAGGGA TGACCAATCC TGAGGTGATT CAGAATCTGG AGCGAGGCTA TCGCATGGTT 1380

AGGCCTGACA ACTGTCCAGA GGAGTTGTAC CACCTCATGA TGCTGTGCTG GAAGGAGCAT 1440

CCAGAGGACC GACCCACCTT TGACTACCTA CGCAGTGTAC TGGAGGACTT CTTCACGGCC 1500

ACAGAGGGCC AGTACCAGCC CCAACCTTGA 1530

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly

Q: 245   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLY  304

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+m++Gsl+dflk+++g kl+++kl+d+aaq+aeGma++ee+n+ihr

Q: 305   AVVTQ-EPIYIITEYMENGSLVDFLKTSSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  363

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 364   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  423

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillteivt+G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pe+

Q: 424   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKEHPED  483

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++l++vl

Q: 484   RPTFDYLRSVL  494

         *******9876

Domain Sequence
(FASTA)

LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHPRLVRLY 60

AVVTQEPIYI ITEYMENGSL VDFLKTSSGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120

LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180

SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPDN CPEELYHLMM LCWKEHPEDR 240

PTFDYLRSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013