EKS-ICT-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	425.7	6.1E-128	50	302	253

Status

Unreviewed

Ensembl Protein

ENSSTOP00000011115

UniProt Accession

I3MJ33;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000012407	ENSSTOP00000011115	ENSSTOT00000012406

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

600

Protein Sequence
(FASTA)

MSAAATAGKL ARAPADPGKV GAPAAGAPAA APLAKEIPEV LVDPRSRRRY VRGRFLGKGG 60

FAKCFEISDA DTKEVFAGKI VPKSLLLKPH QKEKMSMEIS IHRSLAHQHV VGFHGFFEDN 120

DFVFVVLELC RRRSLLELHK RRKALTEPEA RYYLRQIVLG CQYLHRNRVI HRDLKLGNLF 180

LNESLEVKIG DFGLATKVEY DGERKKTLCG TPNYIAPEVL SKKGHSFEVD VWSIGCIMYT 240

LLVGKPPFET SCLKETYLRI KKNEYSIPKH INPVAASLIQ KMLQTDPTAR PTIHELLNDE 300

FFTSGYIPVR LPITCLTIPP RFSIAPSSLD PSNRKPLTVL NKGTEKPQPD RPREKEEPVV 360

RETNEAIECH LSDMLQQLHS VNASKPAERG LVRQEEAEDP ACIPIFWVSK WVDYSDKYGL 420

GYQLCDNSVG VLFNDSTRLI LYDDGDSLQY IERDGTESYL SVSSHPNSLM KKITLLKYFR 480

NYMSEHLLKA GANITPREGD ELARLPYLRT WFRTRSAIIL HLSNGTVQIN FFQDHTKLIL 540

CPLMAAVTYI DEKRDFRTYR LSLLEEFGCC KELASRLRYA RTMVDKLLSS RSACNRLKAS 600

Nucleotide Sequence
(FASTA)

ATGAGTGCGG CGGCGACTGC GGGGAAGCTG GCGCGGGCAC CAGCCGACCC AGGGAAAGTC 60

GGGGCTCCGG CTGCTGGAGC CCCAGCGGCT GCTCCACTAG CGAAAGAGAT CCCCGAGGTC 120

TTAGTGGACC CACGCAGCCG GCGGCGCTAT GTGCGGGGCC GCTTTTTGGG CAAAGGCGGC 180

TTCGCCAAGT GTTTCGAGAT CTCGGACGCA GACACCAAAG AGGTGTTCGC GGGCAAGATC 240

GTGCCTAAGT CTTTGCTGCT TAAGCCGCAC CAGAAAGAGA AGATGTCCAT GGAGATCTCC 300

ATTCACCGCA GCCTGGCCCA CCAGCATGTC GTAGGCTTCC ACGGCTTTTT CGAGGACAAC 360

GATTTCGTGT TCGTGGTGTT GGAGCTCTGC CGCCGGAGGT CGCTCTTGGA GTTGCACAAG 420

AGGCGGAAAG CCCTGACCGA GCCCGAGGCC CGCTACTACC TGCGGCAAAT CGTCCTGGGC 480

TGCCAGTACC TGCATCGAAA CCGGGTGATT CACAGGGACC TCAAGCTGGG CAACCTCTTT 540

CTGAACGAGA GTCTGGAGGT GAAAATAGGG GATTTTGGAC TGGCAACCAA AGTGGAATAT 600

GATGGGGAGC GGAAGAAGAC CCTGTGCGGG ACTCCTAATT ACATAGCTCC CGAGGTGCTG 660

AGCAAGAAGG GGCACAGTTT CGAGGTGGAT GTGTGGTCCA TTGGGTGTAT CATGTATACC 720

TTGTTAGTGG GCAAACCACC TTTTGAGACA TCTTGCCTAA AAGAGACCTA CCTCCGGATC 780

AAGAAGAATG AATACAGTAT TCCCAAGCAC ATCAACCCTG TGGCTGCCTC CCTCATCCAA 840

AAGATGCTCC AGACAGATCC CACTGCCCGC CCCACCATTC ACGAGCTGCT CAATGACGAG 900

TTCTTCACTT CTGGCTACAT CCCTGTCCGT CTCCCCATCA CATGCCTCAC CATCCCACCA 960

AGGTTTTCAA TTGCTCCCAG CAGCCTTGAC CCCAGTAACC GGAAGCCTCT CACAGTCCTC 1020

AATAAAGGCA CAGAGAAGCC CCAGCCTGAT CGTCCTCGGG AAAAAGAGGA ACCAGTGGTT 1080

CGGGAGACGA ATGAGGCGAT CGAATGCCAC CTCAGTGACA TGCTGCAGCA GTTACACAGT 1140

GTCAATGCCT CCAAGCCCGC AGAGCGAGGG CTGGTGAGGC AAGAGGAGGC GGAGGATCCC 1200

GCGTGCATCC CCATCTTCTG GGTCAGCAAG TGGGTGGACT ACTCGGACAA GTATGGCCTC 1260

GGGTATCAGC TGTGTGACAA CAGTGTAGGG GTGCTCTTCA ATGACTCCAC ACGCCTCATC 1320

CTGTACGACG ACGGGGACAG CCTGCAATAC ATAGAGCGCG ACGGCACCGA GTCCTACCTC 1380

TCCGTGAGCT CCCACCCCAA CTCCTTGATG AAGAAGATCA CCCTCCTGAA GTACTTCCGC 1440

AATTACATGA GCGAACACTT GCTGAAGGCG GGCGCCAACA TCACGCCCCG CGAGGGTGAC 1500

GAGCTCGCGC GGCTCCCCTA CCTGCGCACC TGGTTCCGCA CGCGCAGCGC CATCATCTTG 1560

CACCTGAGCA ATGGCACCGT GCAGATCAAC TTCTTCCAGG ACCATACCAA ACTCATCCTG 1620

TGTCCGCTGA TGGCAGCCGT GACCTACATT GACGAGAAGC GGGACTTCCG CACGTACCGC 1680

CTGAGCCTGC TGGAGGAGTT CGGCTGCTGC AAGGAGCTGG CCAGCCGGCT GCGCTACGCC 1740

CGCACCATGG TGGACAAGCT CCTGAGCTCG CGCTCGGCCT GCAACCGCCT CAAGGCCTCC 1800

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y rg++lGkGgfakc+e++d++tkevfa k+vpksll k++q+ek+++ei+ihrsl+h++

Q: 50    YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQH  109

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vlelc+rrsl el+krrkaltepe+ryylrqiv g++ylh++r+

Q: 110   VVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV  169

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgnlflne+levkigdfGlat++e+++erkktlcGtPnyiaPevlskkghs+ev

Q: 170   IHRDLKLGNLFLNESLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEV  229

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+Ws+Gci+ytllvGkPPfet++lkety +ikk+eys+P+++++ a+sli+k+l+++P++

Q: 230   DVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTA  289

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++e+l+def+

Q: 290   RPTIHELLNDEFF  302

         ************8

Domain Sequence
(FASTA)

YVRGRFLGKG GFAKCFEISD ADTKEVFAGK IVPKSLLLKP HQKEKMSMEI SIHRSLAHQH 60

VVGFHGFFED NDFVFVVLEL CRRRSLLELH KRRKALTEPE ARYYLRQIVL GCQYLHRNRV 120

IHRDLKLGNL FLNESLEVKI GDFGLATKVE YDGERKKTLC GTPNYIAPEV LSKKGHSFEV 180

DVWSIGCIMY TLLVGKPPFE TSCLKETYLR IKKNEYSIPK HINPVAASLI QKMLQTDPTA 240

RPTIHELLND EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013