EKS-ICT-00029
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00029
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak324.65.2E-97584846263
StatusUnreviewed
Ensembl ProteinENSSTOP00000011135
UniProt AccessionI3MJ48;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK1
Gene Synonyms/Alias JAK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000012422ENSSTOP00000011135ENSSTOT00000012426
ENSSTOG00000012422ENSSTOP00000019944ENSSTOT00000023314
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length1129
Protein Sequence
(FASTA)
MQYLNIKEDC NAMAFCAKMR SSKKAEVNQV APEPGVEVTF YLPDREPLRL GTGEYTAEEL 60
CIRAAQECCI SPLCHNLFAL YDENTKLWYA PNRTITIDDK ISLRLHYRMR FYFTNWHGTN 120
DSEQSVWRHS PKKQKNGYEK KKVPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180
DGHDIENECL GMAVLAISHY AMMKKVQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240
NNVFKDFLKE FNNKTICDSS VSPHDLKVKY LATLETLTKH YGAEIFETSM LLISSENEMN 300
WLHSNDSGNV LSYEVMVTGN LGIQWRQKPN VVPVEKEKNK LKRKKLENKH KKDEEKNKIQ 360
EEWNNFSYFP EITHIVIKES MVSINKQDNK KMELKLSSHE EALSFVSLVD GYFRLTADAH 420
HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGNEE GMYVLRWSCT DFDNILMTVT 480
CFEKSEVLGT HKQFKNFQIE VQKGRYSLHG SDRNFPTLEG LMSHLKKQIL RTDNISFVLK 540
RCCQPKPREI SNLLVATKKA QEWQPVYPMS QLSFDRILKK DIVQGDHLGR GTRTHIYSGT 600
LVDYKDDEGA AEEKRIKVIL KVLDPSHRDI SLAMAFFEAA SMMRQVSHKH IVYLYGVCVR 660
DVENIMVEEY VEGGPLDLFM HRKSDVLTTP WKFKVAKQLA SALSYLEDKD LVHGNVCTKN 720
LLLAREGIDS EIGPFIKLSD PGIPVTVLSR QECIERIPWI APECVEDSKN LSVAADKWSF 780
GTTLWEICYN GEIPLKDKTL IEKERFYESR CRPVTPSCKE LADLMTRCMN YDPNQRPFFR 840
AIMRDINKLE EQNPDIVSEK KPATEVDPTH FEKRFLKRIR DLGEGHFGKV ELCRYDPEGD 900
NTGEQVAVKS LKPESGGNHI ADLKKEIEIL RNLYHENIVK YKGICTEDGG NGIKLIMEFL 960
PSGSLKEYLP KNKNKINLKQ QLKYAVQICK GMDYLGSRQY VHRDLAARNV LVESEHQVKI 1020
GDFGLTKAIE TDKEYYTVKD DRDSPVFWYA PECLIQCKFY IASDVWSFGV TLHELLTYCD 1080
SESSPMALFL KMIGPTQGQM TVTRLVNTLK EGKRLPCPPN CPDKVFIFP 1129
Nucleotide Sequence
(FASTA)
ATGCAGTATC TAAATATAAA AGAAGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 60
AGCTCCAAGA AAGCGGAGGT GAATCAGGTG GCCCCTGAGC CAGGGGTGGA AGTGACCTTC 120
TATCTGCCAG ACAGGGAGCC CCTCCGGCTG GGCACTGGAG AGTACACAGC AGAAGAGCTG 180
TGCATCAGGG CAGCGCAGGA ATGCTGTATA TCTCCTCTAT GCCACAACCT CTTTGCCTTG 240
TATGATGAGA ACACCAAGCT CTGGTATGCT CCGAACCGCA CCATCACCAT TGATGACAAG 300
ATATCACTCC GACTGCACTA CCGCATGAGG TTCTACTTCA CAAACTGGCA TGGAACCAAT 360
GACAGTGAGC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAG 420
AAAAAGGTTC CAGATGCAAC CCCTCTCCTT GATGCCAGCT CGCTGGAGTA CCTGTTTGCT 480
CAGGGTCAGT ATGATTTGGT CAAATGCCTG GCTCCCATTC GGGACCCCAA GACTGAGCAG 540
GATGGGCATG ATATTGAGAA TGAGTGCCTG GGAATGGCTG TCTTGGCCAT TTCGCACTAT 600
GCCATGATGA AGAAGGTGCA ATTGCCGGAA CTTCCCAAGG ACATCAGCTA CAAGCGATAT 660
ATTCCAGAAA CATTGAATAA ATCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATA 720
AATAATGTTT TCAAGGATTT CCTAAAGGAA TTTAACAACA AGACCATTTG TGACAGCAGT 780
GTGTCCCCTC ATGACCTGAA GGTGAAATAC CTGGCTACCT TGGAAACTTT GACAAAACAT 840
TATGGGGCTG AAATATTTGA GACTTCTATG TTATTAATTT CATCAGAAAA TGAAATGAAT 900
TGGCTTCATT CAAATGACAG TGGAAATGTT CTCTCCTATG AAGTGATGGT AACTGGAAAT 960
CTTGGAATCC AGTGGCGGCA GAAACCAAAT GTTGTTCCGG TTGAAAAGGA AAAAAATAAA 1020
CTGAAGCGAA AAAAACTGGA AAATAAACAC AAGAAGGATG AGGAGAAAAA TAAAATCCAG 1080
GAAGAATGGA ATAATTTTTC TTATTTCCCT GAAATCACTC ACATTGTAAT CAAGGAGTCT 1140
ATGGTCAGCA TTAATAAGCA GGACAACAAA AAAATGGAAC TGAAGCTTTC TTCCCATGAG 1200
GAGGCCTTGT CCTTTGTGTC CCTGGTTGAT GGCTACTTCC GGCTCACAGC AGATGCCCAT 1260
CATTACCTCT GCACTGATGT AGCTCCCCCA TTGATAGTCC ACAACATACA GAATGGCTGC 1320
CATGGTCCAA TCTGCACAGA ATATGCCATC AATAAGCTGC GGCAAGAAGG GAACGAGGAG 1380
GGAATGTACG TGCTGAGGTG GAGTTGTACC GACTTTGACA ACATCCTCAT GACTGTCACC 1440
TGCTTTGAAA AGTCTGAGGT GCTGGGTACC CATAAGCAAT TCAAGAATTT TCAGATCGAG 1500
GTACAGAAGG GCCGCTATAG CCTGCATGGC TCAGATCGCA ACTTCCCCAC CCTGGAAGGC 1560
CTCATGAGCC ACCTCAAGAA GCAGATCCTG CGCACAGACA ACATTAGCTT TGTGCTGAAG 1620
CGCTGCTGCC AGCCCAAGCC TCGAGAAATC TCCAATCTGT TGGTGGCCAC CAAGAAGGCC 1680
CAGGAGTGGC AGCCTGTCTA CCCCATGAGC CAGCTGAGCT TTGACCGGAT CCTCAAGAAA 1740
GATATTGTTC AAGGTGATCA CCTTGGCAGA GGCACGAGAA CACACATCTA CTCTGGGACC 1800
TTGGTGGATT ACAAGGACGA TGAAGGGGCT GCTGAAGAGA AGAGAATAAA AGTGATCCTC 1860
AAAGTCTTAG ACCCCAGCCA CAGGGACATT TCTCTGGCAA TGGCCTTCTT TGAAGCAGCC 1920
AGCATGATGA GACAGGTCTC CCACAAACAC ATTGTGTACC TCTATGGCGT CTGTGTCCGA 1980
GATGTGGAAA ATATCATGGT GGAAGAGTAT GTGGAGGGGG GACCCCTGGA TCTTTTTATG 2040
CATCGGAAAA GCGATGTCCT CACTACACCA TGGAAATTCA AAGTTGCCAA ACAGCTGGCC 2100
AGTGCCCTGA GTTACTTGGA AGATAAAGAC CTGGTCCATG GAAATGTGTG TACCAAAAAT 2160
CTCCTCCTGG CCCGTGAGGG CATTGACAGT GAAATTGGCC CGTTCATCAA GCTTAGTGAC 2220
CCTGGAATCC CTGTCACTGT ACTGTCAAGG CAAGAGTGCA TAGAACGAAT CCCATGGATT 2280
GCTCCAGAGT GTGTTGAAGA CTCCAAGAAC CTGAGTGTGG CTGCTGACAA ATGGAGCTTT 2340
GGTACCACAC TCTGGGAAAT CTGCTATAAT GGCGAGATCC CCCTGAAAGA TAAGACTCTG 2400
ATTGAGAAAG AGAGATTCTA TGAAAGCCGG TGCAGGCCAG TGACACCATC ATGCAAGGAG 2460
CTGGCTGACC TTATGACCCG CTGTATGAAC TATGACCCCA ATCAGAGACC CTTCTTCCGA 2520
GCCATTATGA GGGACATTAA CAAGCTCGAA GAGCAAAATC CAGACATTGT TTCAGAAAAA 2580
AAACCAGCAA CTGAGGTGGA TCCCACGCAT TTTGAAAAGC GCTTCCTGAA GAGGATACGT 2640
GACTTGGGAG AGGGCCACTT TGGGAAGGTT GAGCTCTGCA GGTATGACCC AGAGGGGGAC 2700
AACACAGGGG AGCAGGTAGC TGTCAAATCC CTGAAGCCTG AGAGTGGAGG TAACCACATT 2760
GCTGATCTGA AGAAGGAAAT AGAAATCTTA AGGAATCTCT ATCATGAGAA CATCGTGAAG 2820
TACAAAGGAA TCTGCACTGA AGATGGAGGA AATGGTATCA AGCTCATCAT GGAGTTTCTG 2880
CCTTCTGGAA GCCTTAAGGA ATATCTTCCA AAGAATAAGA ACAAAATTAA CCTTAAACAG 2940
CAGCTAAAAT ATGCTGTTCA GATTTGTAAG GGAATGGACT ATTTGGGTTC TCGGCAATAT 3000
GTTCACCGGG ACTTAGCAGC AAGAAATGTC CTTGTTGAGA GTGAACACCA AGTGAAAATT 3060
GGAGACTTTG GTTTAACCAA AGCAATTGAA ACTGATAAGG AGTACTACAC CGTCAAAGAT 3120
GATCGGGACA GCCCTGTGTT TTGGTATGCT CCAGAATGTT TAATTCAGTG TAAATTTTAT 3180
ATTGCCTCTG ATGTCTGGTC TTTTGGAGTG ACTCTGCATG AGCTGCTTAC TTACTGTGAT 3240
TCAGAGTCTA GTCCAATGGC TTTGTTCCTG AAAATGATAG GCCCAACTCA AGGCCAGATG 3300
ACGGTAACAA GACTTGTGAA TACGCTGAAA GAAGGAAAAC GTTTACCATG CCCGCCTAAC 3360
TGTCCTGATA AGGTATTTAT CTTTCCATAG 3390
Domain Profile
S: 3     qiesLgkgtftkvfevre....daegdsteee..valkvLkesgedis..rdfkreaeil  54
         q ++Lg+gt+t+++++++    d+eg ++e+   v+lkvL++s++dis  ++f+++a+++
Q: 584   QGDHLGRGTRTHIYSGTLvdykDDEGAAEEKRikVILKVLDPSHRDISlaMAFFEAASMM  643
         679**************98776577777777678***********9873368********
S: 55    sqlshehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakam  114
         +q+sh+hiv+l+gvcv++ en++V+eyve G+Ld ++++k++ l+++++++vakqla+a+
Q: 644   RQVSHKHIVYLYGVCVRDVENIMVEEYVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASAL  703
         ************************************************************
S: 115   eYLedkklvhrdvaarnvLveresn.egtppfvklsdpglakavnqdeYylvreerdsri  173
         +YLedk+lvh++v+++n+L++re+  ++ +pf+klsdpg+  +v      l+r+e+ +ri
Q: 704   SYLEDKDLVHGNVCTKNLLLAREGIdSEIGPFIKLSDPGIPVTV------LSRQECIERI  757
         ************************9899****************......**********
S: 174   pwlapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpk  233
         pw+apec++++knls+a+d+WsFg+tl+e+  c++ge pl++++l++k++++e+++r+++
Q: 758   PWIAPECVEDSKNLSVAADKWSFGTTLWEI--CYNGEIPLKDKTLIEKERFYESRCRPVT  815
         ******************************..****************************
S: 234   pkcpaelaelmtnclsyepsqrpsFrailedl  265
         p+c+ ela+lmt+c++y+p+qrp+Frai++d+
Q: 816   PSCK-ELADLMTRCMNYDPNQRPFFRAIMRDI  846
         ****.*************************96
Domain Sequence
(FASTA)
QGDHLGRGTR THIYSGTLVD YKDDEGAAEE KRIKVILKVL DPSHRDISLA MAFFEAASMM 60
RQVSHKHIVY LYGVCVRDVE NIMVEEYVEG GPLDLFMHRK SDVLTTPWKF KVAKQLASAL 120
SYLEDKDLVH GNVCTKNLLL AREGIDSEIG PFIKLSDPGI PVTVLSRQEC IERIPWIAPE 180
CVEDSKNLSV AADKWSFGTT LWEICYNGEI PLKDKTLIEK ERFYESRCRP VTPSCKELAD 240
LMTRCMNYDP NQRPFFRAIM RDI 263
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00025
EKS-ANC-00026
EKS-BOT-00032
EKS-CAJ-00029
EKS-CAF-00030
EKS-CAP-00031
EKS-DAR-00043
EKS-EQC-00029
EKS-FEC-00027
EKS-GAG-00026
EKS-GAA-00048
EKS-GOG-00028
EKS-HOS-00031
EKS-LAC-00032
EKS-LOA-00029
EKS-MAM-00029
EKS-MEG-00024
EKS-MIM-00015
EKS-MUM-00031
EKS-MUP-00031
EKS-MYL-00031
EKS-ORN-00048
EKS-ORC-00030
EKS-ORL-00045
EKS-OTG-00033
EKS-PAT-00028
EKS-PES-00028
EKS-POA-00027
EKS-RAN-00031
EKS-SAH-00028
EKS-TAG-00029
EKS-TAR-00048
EKS-TEN-00051
EKS-XET-00031
EKS-XIM-00046
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776; Tyr_kinase_non-rcpt_Jak1.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01824; JANUSKINASE1.
PR00109; TYRKINASE.
Created Date20-Feb-2013