EKS-ICT-00163
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00163
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC480.01.9E-144246504259
StatusUnreviewed
Ensembl ProteinENSSTOP00000011139
UniProt AccessionI3MJ52;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000012429ENSSTOP00000011139ENSSTOT00000012430
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length579
Protein Sequence
(FASTA)
DPRSKHKFKI HTYSSPTFCD HCGSLLYGLI HQGMKCDTCM MNVHKRCVMN VPSLCGTDHT 60
ERRGRIYIQA HIDREILIVV VRDAKNLVPM DPNGLSDPYV KLKLIPDPKS ESKQKTKTIK 120
CSLNPEWNET FRFQLKESDK DRRLSVEIWD WDLTSRNDFM GSLSFGISEL QKAGVDGWFK 180
LLSQEEGEYF NVPVPPEGSE GNEELRQKFE RAKIGQGTKT PEEKTSNTIS KLDNNGNRDR 240
MKLTDFNFLM VLGKGSFGKV MLSERKGTDE LYAVKILKKD VVIQDDDVEC TMVEKRVLAL 300
PGKPPFLTQL HSCFQTMDRL YFVMEYVNGG DLMYHIQQVG RFKEPHAVFY AAEIAIGLFF 360
LQSKGIIYRD LKLDNVMLDS EGHIKIADFG MCKENIWDGV TTKTFCGTPD YIAPEIIAYQ 420
PYGKSVDWWA FGVLLYEMLA GQAPFEGEDE DELFQSIMEH NVAYPKSMSK EAVAICKGLM 480
TKHPGKRLGC GPEGERDIKE HAFFRYIDWE KLERKEIQPP YKPKACGRNA ENFDRFFTRH 540
PPVLTPPDQE VIRNIDQSEF EGFSFVNSEF LKPEVKRSV 579
Nucleotide Sequence
(FASTA)
GATCCCCGGA GCAAGCACAA GTTTAAGATC CACACCTACT CCAGCCCCAC GTTTTGTGAC 60
CACTGTGGGT CCCTGCTGTA CGGACTCATC CACCAGGGGA TGAAATGTGA CACCTGCATG 120
ATGAATGTCC ACAAGCGCTG CGTCATGAAC GTCCCCAGCC TCTGCGGCAC CGACCACACG 180
GAGCGCCGTG GCCGCATCTA CATCCAGGCC CACATCGACA GGGAGATCCT CATCGTGGTC 240
GTAAGAGACG CTAAAAACCT GGTACCCATG GATCCCAACG GCTTGTCAGA TCCCTACGTG 300
AAGCTGAAAC TCATCCCTGA TCCCAAGAGC GAGAGCAAGC AGAAGACCAA GACCATCAAG 360
TGCTCTCTGA ACCCCGAGTG GAACGAGACG TTCCGATTTC AGCTGAAGGA GTCCGACAAA 420
GACAGGAGGC TCTCGGTAGA GATCTGGGAC TGGGATCTGA CCAGCCGCAA TGACTTCATG 480
GGGTCCTTGT CCTTCGGGAT CTCTGAACTG CAGAAAGCTG GCGTCGATGG CTGGTTCAAG 540
CTGCTGAGCC AGGAGGAGGG CGAGTACTTC AACGTGCCTG TGCCGCCCGA GGGCAGCGAG 600
GGCAATGAAG AGCTGCGCCA GAAGTTCGAG AGGGCCAAGA TCGGCCAGGG GACCAAGACC 660
CCCGAGGAGA AGACCAGCAA CACCATCTCC AAATTGGACA ACAACGGCAA CAGGGACCGG 720
ATGAAGCTGA CCGACTTCAA CTTCCTGATG GTGCTGGGGA AGGGCAGCTT TGGCAAGGTC 780
ATGCTGTCGG AGCGGAAGGG CACAGACGAG CTGTACGCCG TGAAGATCCT CAAGAAGGAC 840
GTGGTGATCC AAGACGACGA CGTGGAGTGC ACCATGGTGG AGAAGCGGGT GCTGGCCCTG 900
CCCGGGAAGC CGCCCTTCCT GACCCAGCTC CACTCCTGCT TCCAGACCAT GGACCGCCTG 960
TATTTTGTGA TGGAGTACGT GAACGGGGGC GACCTCATGT ACCACATCCA ACAAGTGGGC 1020
CGGTTCAAGG AGCCTCATGC TGTATTTTAC GCTGCAGAAA TCGCCATCGG CCTGTTCTTC 1080
TTGCAGAGCA AGGGCATCAT TTACCGGGAC CTGAAGCTGG ACAACGTGAT GCTGGATTCC 1140
GAGGGTCACA TCAAGATCGC CGACTTTGGC ATGTGTAAGG AGAACATCTG GGACGGCGTG 1200
ACCACCAAGA CGTTCTGTGG GACTCCGGAC TACATTGCCC CCGAGATAAT CGCTTACCAA 1260
CCCTACGGGA AGTCCGTGGA TTGGTGGGCC TTCGGAGTCC TGCTGTACGA GATGTTGGCC 1320
GGGCAGGCAC CGTTCGAAGG GGAGGACGAG GACGAACTCT TCCAGTCCAT CATGGAGCAC 1380
AATGTGGCCT ATCCAAAGTC CATGTCCAAG GAAGCCGTGG CCATCTGCAA AGGGCTGATG 1440
ACCAAACACC CAGGCAAACG TCTGGGTTGT GGCCCTGAAG GGGAACGTGA CATCAAAGAG 1500
CATGCATTTT TCCGGTATAT TGATTGGGAG AAACTTGAAC GCAAGGAGAT TCAGCCTCCA 1560
TATAAACCCA AAGCTTGTGG GCGAAATGCT GAGAACTTCG ACCGGTTTTT CACCCGCCAT 1620
CCACCCGTCC TTACACCTCC CGACCAGGAA GTCATCAGGA ATATTGACCA GTCAGAATTC 1680
GAAGGATTTT CCTTTGTTAA CTCTGAATTT TTAAAACCTG AAGTCAAGAG GTCTGTC 1737
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 246   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  305
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg
Q: 306   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  365
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 366   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  425
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 426   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  485
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 486   KRLGCGPEGERDIKEHAFF  504
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00168
EKS-CAJ-00172
EKS-CAF-00175
EKS-CAP-00168
EKS-DAR-00459
EKS-EQC-00173
EKS-FEC-00158
EKS-GAM-00088
EKS-GAG-00144
EKS-GAA-00202
EKS-GOG-00171
EKS-HOS-00174
EKS-LAC-00180
EKS-LOA-00167
EKS-MAM-00166
EKS-MOD-00167
EKS-MUM-00173
EKS-MUP-00172
EKS-MYL-00177
EKS-NOL-00161
EKS-OCP-00107
EKS-ORN-00212
EKS-ORC-00156
EKS-OTG-00174
EKS-PAT-00159
EKS-PES-00148
EKS-POA-00165
EKS-RAN-00164
EKS-SAH-00162
EKS-TEN-00211
EKS-XET-00157
EKS-XIM-00206
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013