EKS-ICT-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	471.5	7.3E-142	271	531	261

Status

Unreviewed

Ensembl Protein

ENSSTOP00000011308

UniProt Accession

I3MJI3;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCE

Gene Synonyms/Alias

PRKCE;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000012596	ENSSTOP00000011308	ENSSTOT00000012617

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

600

Protein Sequence
(FASTA)

APKDNEERVF RERMRPRKRQ GAVRRRVHQV NGHKFMATYL RQPTYCSHCR DFIWGVIGKQ 60

GYQCQVCTCV VHKRCHELII TKCAGLKRQE TPDEVGSQRF SVNMPHKFGI HNYKVPTFCD 120

HCGSLLWGLL RQGLQCKVCK MNVHRRCETN VAPNCGVDAR GIAKVLADLG VTPDKITNSG 180

QRRKKLVAGA ESPQPASGSS PSEEDRSKSA PTSPCDQELK ELENNIRKAL SFDNRGEEHR 240

ASSSTDGQLG SPGENGEVRQ GQAKRLGLDE FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK 300

VLKKDVILQD DDVDCTMTEK RILALARKHP YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ 360

IQRSRKFDEP RSRFYAAEVT SALMFLHQHG VIYRDLKLDN ILLDAEGHCK LADFGMCKEG 420

ILNGVTTTTF CGTPDYIAPE ILQELEYGPS VDWWALGVLM YEMMAGQPPF EADNEDDLFE 480

SILHDDVLYP VWLSKEAVSI LKAFMTKNPH KRLGCVAVQN GEDAIKQHPF FKEIDWVLLE 540

QKKIKPPFKP RIKTKRDVNN FDQDFTREEP VLTLVDEAIV KQINQEEFKG FSYFGEDLMP 600

Nucleotide Sequence
(FASTA)

GCCCCTAAAG ACAATGAAGA GCGTGTGTTC AGGGAGCGTA TGCGGCCAAG GAAGCGGCAA 60

GGGGCCGTCA GACGCAGGGT CCACCAGGTC AATGGCCACA AGTTCATGGC CACCTACCTT 120

CGGCAGCCCA CCTACTGCTC CCACTGCAGA GACTTCATCT GGGGTGTCAT AGGAAAGCAG 180

GGATACCAAT GTCAAGTTTG CACTTGCGTC GTCCACAAGC GATGCCATGA GCTCATAATC 240

ACCAAGTGCG CTGGATTAAA GAGACAGGAA ACACCCGATG AGGTGGGCTC ACAGCGGTTC 300

AGCGTCAACA TGCCCCACAA GTTTGGGATC CACAACTACA AAGTCCCCAC CTTCTGTGAC 360

CACTGTGGGT CCTTGCTCTG GGGTCTCTTG CGGCAGGGTT TGCAGTGTAA AGTCTGCAAA 420

ATGAATGTTC ACCGTCGATG TGAGACCAAT GTGGCTCCCA ACTGTGGAGT GGATGCCAGA 480

GGGATCGCCA AAGTGCTGGC GGACCTAGGT GTCACTCCGG ACAAAATCAC CAACAGCGGC 540

CAGAGGAGGA AAAAGCTTGT TGCTGGTGCC GAGTCCCCAC AGCCAGCTTC TGGAAGCTCC 600

CCATCTGAAG AAGATCGATC CAAGTCAGCA CCCACCTCCC CTTGTGACCA GGAACTAAAA 660

GAACTTGAAA ACAATATCCG GAAAGCCTTG TCGTTTGATA ATCGAGGGGA GGAGCACCGA 720

GCATCATCGT CCACGGACGG CCAGCTGGGG AGCCCTGGTG AGAACGGTGA AGTCCGGCAA 780

GGCCAGGCCA AGCGTTTGGG CCTGGACGAG TTCAACTTCA TCAAGGTGTT GGGCAAAGGC 840

AGCTTTGGCA AGGTCATGTT GGCGGAACTC AAGGGCAAAG ATGAAGTATA TGCTGTGAAA 900

GTCTTAAAGA AGGATGTCAT CCTTCAGGAC GATGATGTAG ACTGCACGAT GACAGAGAAG 960

AGGATTTTGG CACTGGCACG GAAACACCCA TACCTAACCC AACTCTATTG CTGCTTCCAG 1020

ACCAAGGACC GCCTCTTTTT CGTCATGGAA TATGTGAATG GTGGAGACCT CATGTTCCAG 1080

ATTCAGCGCT CCCGAAAATT TGACGAGCCT CGTTCACGAT TCTATGCTGC CGAGGTCACG 1140

TCGGCCCTCA TGTTCCTGCA CCAGCATGGC GTGATCTACA GGGATTTGAA ACTGGACAAC 1200

ATTCTTCTAG ATGCAGAAGG TCACTGCAAA CTGGCCGACT TTGGGATGTG CAAGGAAGGG 1260

ATTCTGAACG GCGTGACAAC CACCACATTC TGTGGGACTC CCGATTACAT AGCTCCGGAG 1320

ATCCTGCAGG AGTTGGAATA TGGCCCCTCA GTGGACTGGT GGGCCCTGGG AGTGCTGATG 1380

TATGAGATGA TGGCTGGGCA GCCTCCCTTT GAGGCTGACA ACGAGGACGA CCTGTTTGAG 1440

TCCATCCTCC ATGATGATGT GCTGTACCCA GTCTGGCTCA GCAAGGAGGC CGTCAGCATC 1500

TTGAAAGCCT TCATGACCAA GAACCCCCAC AAGCGCCTGG GCTGTGTGGC TGTGCAGAAC 1560

GGTGAAGACG CCATCAAGCA GCACCCCTTC TTCAAGGAGA TCGACTGGGT GCTCCTGGAG 1620

CAGAAGAAGA TCAAGCCGCC CTTCAAACCG AGAATTAAAA CCAAAAGAGA TGTCAATAAC 1680

TTTGACCAAG ACTTTACTCG GGAAGAGCCG GTGCTCACAC TTGTGGATGA AGCAATAGTG 1740

AAGCAGATCA ACCAGGAGGA ATTCAAAGGC TTCTCCTACT TCGGTGAAGA CCTCATGCCT 1800

TGA 1803

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p

Q: 271   FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  330

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g

Q: 331   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  390

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s

Q: 391   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  450

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+

Q: 451   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  510

         ************************************************************

S: 241   krlGvk..eegeedikehaff  259

         krlG+   ++ge++ik+h+ff

Q: 511   KRLGCVavQNGEDAIKQHPFF  531

         *****4469***********9

Domain Sequence
(FASTA)

FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60

YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120

VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180

VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240

KRLGCVAVQN GEDAIKQHPF F 261

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013