EKS-ICT-00440
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00440
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK413.92.9E-12426321296
StatusUnreviewed
Ensembl ProteinENSSTOP00000011309
UniProt AccessionI3MJI4; I3M116;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK8
Gene Synonyms/Alias MAPK8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000012617ENSSTOP00000011309ENSSTOT00000012618
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length427
Protein Sequence
(FASTA)
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360
MDLEERTKNG VIRGQPSPLG AAMINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEASA 420
GPLGCCR 427
Nucleotide Sequence
(FASTA)
ATGAGCAGAA GCAAGCGGGA CAACAATTTT TATAGTGTAG AAATTGGAGA TTCTACATTC 60
ACAGTCCTGA AACGGTATCA GAATTTAAAA CCTATAGGCT CCGGAGCTCA AGGAATAGTT 120
TGTGCAGCTT ATGATGCCAT TCTTGAAAGA AATGTTGCAA TCAAGAAGCT AAGCCGGCCA 180
TTTCAGAATC AAACTCATGC TAAGCGGGCC TACAGAGAAC TAGTTCTTAT GAAATGTGTT 240
AATCATAAAA ATATAATTGG ACTTTTGAAT GTTTTCACAC CACAGAAATC CCTAGAAGAA 300
TTTCAAGATG TTTACATAGT CATGGAGCTC ATGGATGCAA ATCTTTGCCA AGTGATTCAG 360
ATGGAACTAG ATCATGAAAG AATGTCCTAC CTTCTCTATC AGATGCTGTG TGGAATCAAG 420
CACCTTCATT CTGCTGGAAT TATTCATCGG GATTTAAAGC CCAGTAATAT AGTAGTAAAA 480
TCAGATTGCA CTTTGAAGAT TCTTGACTTT GGACTGGCTA GAACTGCAGG AACAAGTTTT 540
ATGATGACTC CTTATGTAGT GACTCGATAC TACAGAGCAC CTGAGGTCAT CCTAGGCATG 600
GGCTACAAGG AAAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660
GGTGGTGTTT TGTTCCCAGG TACAGATCAT ATTGATCAGT GGAATAAAGT TATTGAACAG 720
CTTGGAACAC CGTGTCCTGA ATTTATGAAG AAACTACAAC CAACAGTAAG GACTTATGTT 780
GAAAACAGAC CTAAATATGC TGGATATAGC TTTGAGAAAC TCTTCCCTGA TGTACTTTTC 840
CCAGCTGACT CAGAACACAA CAAACTTAAA GCCAGTCAGG CAAGGGATTT GTTATCCAAA 900
ATGCTGGTCA TAGATGCATC TAAAAGGATC TCTGTAGATG AAGCTCTTCA GCATCCATAC 960
ATCAATGTCT GGTATGATCC TTCTGAAGCA GAAGCTCCAC CACCAAAGAT CCCTGATAAG 1020
CAGTTAGATG AAAGAGAACA CACAATAGAA GAGTGGAAAG AATTGATATA CAAAGAAGTG 1080
ATGGACTTGG AGGAGAGAAC CAAGAATGGA GTTATACGAG GGCAGCCCTC TCCTTTAGGT 1140
GCAGCAATGA TCAATGGCTC TCAGCATCCA TCGTCATCGT CGTCTGTCAA TGATGTGTCT 1200
TCAATGTCAA CAGATCCGAC TTTGGCCTCA GATACAGACA GCAGTCTAGA AGCATCAGCT 1260
GGACCTCTGG GCTGCTGTAG ATGA 1284
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni
Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs
Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144
         ************************************9.**********************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  + 
Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201
         **********************************976..*****************9.99
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+
Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260
         *****************************************************.5*****
S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288
         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY
Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320
         *****************************99*****************************
S: 289   l  289
         +
Q: 321   I  321
         7
Domain Sequence
(FASTA)
YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60
IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120
GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180
VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240
YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00433
EKS-ANC-00452
EKS-BOT-00465
EKS-CAE-00386
EKS-CAJ-00470
EKS-CAF-00466
EKS-CAP-00497
EKS-CII-00262
EKS-CIS-00222
EKS-DAR-00873
EKS-DRM-00223
EKS-ECT-00062
EKS-EQC-00453
EKS-FEC-00443
EKS-GAM-00270
EKS-GAG-00388
EKS-GAA-00564
EKS-GOG-00455
EKS-HOS-00474
EKS-LAC-00476
EKS-LOA-00470
EKS-MAM-00462
EKS-MEG-00380
EKS-MIM-00086
EKS-MOD-00457
EKS-MUM-00498
EKS-MUP-00455
EKS-MYL-00456
EKS-NOL-00422
EKS-OCP-00121
EKS-ORN-00586
EKS-ORA-00401
EKS-ORC-00439
EKS-OTG-00472
EKS-PAT-00438
EKS-PES-00409
EKS-PEM-00255
EKS-POA-00453
EKS-PRC-00063
EKS-RAN-00479
EKS-SAH-00433
EKS-SUS-00407
EKS-TAG-00527
EKS-TAR-00576
EKS-TAS-00066
EKS-TEN-00576
EKS-TUB-00050
EKS-TUT-00171
EKS-VIP-00088
EKS-XET-00612
EKS-XIM-00574
Gene Ontology
GO:0005524; F:ATP binding
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008351; MAPK_JNK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01772; JNKMAPKINASE.
Created Date20-Feb-2013