EKS-ICT-00168

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00168

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	439.3	5.1E-132	148	414	267

Status

Unreviewed

Ensembl Protein

ENSSTOP00000011476

UniProt Accession

I3MJU3;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCZ

Gene Synonyms/Alias

PRKCZ;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000012801	ENSSTOP00000011476	ENSSTOT00000012804

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

MPCPGEDKSI YRRGARRWRK LYQANGHLFQ AKRFNRKAYC GQCSERIWGL ARQGYRCVHC 60

KLLVHKRCHG LVPLTCRRLM DSVMPSQEPP VAEKSDGVDL PSEETDGIAY ISSSRKHEGI 120

KDDSEDLKPV IDGVDGIKIS QGLGLQDFDL IRVIGRGSYA KVLLVRLKKN DQVYAMKVVK 180

KELVHDDEDI DWVQTEKHVF EQASSNPFLV GLHSCFQTTS RLFLVIEYVN GGDLMFHMQR 240

QRKLPEEHAR FYAAEICIAL NFLHERGIIY RDLKLDNVLL DADGHIKLTD YGMCKEGLGP 300

GDTTSTFCGT PNYIAPEILR GEEYGFSVDW WALGVLMFEM MAGRSPFDII TDNPDMNTED 360

YLFQVILEKP IRIPRFLSVK ASHVLKGFLN KDPKERLGCR PQTGFSDIKS HAFFRSIDWD 420

LLEKKQALPP FQPQITDDYG LDNFDTQFTS EPVQLTPDDE DVIKRIDQSE FEGFEYINPL 480

LLSTEESV 488

Nucleotide Sequence
(FASTA)

ATGCCCTGTC CTGGAGAAGA CAAGTCCATC TACCGCCGGG GAGCCAGGAG ATGGAGGAAG 60

CTGTACCAGG CCAACGGCCA CCTCTTCCAG GCCAAGCGCT TTAACAGGAA GGCGTACTGT 120

GGCCAGTGCA GTGAAAGGAT ATGGGGCCTC GCCAGGCAGG GCTACAGGTG CGTCCACTGC 180

AAGCTGCTGG TCCATAAGCG CTGCCACGGC CTCGTCCCGC TGACCTGCAG AAGGCTTATG 240

GATTCTGTCA TGCCTTCCCA GGAGCCTCCA GTAGCTGAGA AGAGCGACGG CGTGGACCTT 300

CCCTCGGAGG AGACCGATGG AATTGCGTAC ATTTCTTCCT CCCGGAAGCA CGAGGGCATC 360

AAAGACGATT CCGAGGACCT GAAACCTGTC ATCGATGGGG TCGACGGGAT CAAGATCTCT 420

CAGGGGCTCG GGCTGCAGGA CTTCGACCTC ATCAGGGTCA TCGGGCGCGG CAGCTACGCC 480

AAGGTCCTCC TGGTGCGGCT CAAGAAGAAC GACCAGGTCT ACGCCATGAA GGTGGTCAAG 540

AAGGAGCTGG TCCACGACGA CGAGGATATC GACTGGGTGC AGACAGAGAA GCACGTGTTT 600

GAGCAGGCAT CCAGCAACCC CTTCCTCGTC GGCTTACACT CCTGCTTCCA GACAACCAGC 660

AGGTTGTTCC TGGTCATAGA GTACGTCAAC GGTGGGGACC TCATGTTCCA CATGCAGAGA 720

CAGAGGAAGC TCCCGGAGGA ACACGCCAGG TTCTACGCGG CTGAGATCTG CATTGCTCTC 780

AACTTCTTGC ATGAGAGAGG GATCATCTAC CGGGACCTGA AGCTGGACAA TGTGCTTCTG 840

GACGCTGATG GACACATCAA GCTGACAGAC TACGGCATGT GCAAGGAAGG CCTGGGCCCT 900

GGGGACACCA CCAGCACTTT CTGCGGAACC CCAAATTACA TCGCCCCGGA AATCCTGCGG 960

GGAGAGGAGT ACGGGTTCAG CGTGGACTGG TGGGCGCTGG GCGTCCTCAT GTTCGAGATG 1020

ATGGCCGGGC GCTCCCCCTT CGACATCATC ACCGACAACC CTGACATGAA CACAGAGGAC 1080

TACCTTTTCC AAGTTATCCT GGAGAAGCCG ATCCGCATCC CCCGGTTCCT CTCCGTCAAA 1140

GCCTCCCACG TCTTGAAAGG ATTCCTAAAC AAGGACCCCA AGGAGAGGCT CGGCTGCCGG 1200

CCACAGACTG GCTTTTCGGA CATCAAGTCC CACGCCTTCT TCCGCAGCAT CGACTGGGAC 1260

CTGCTAGAGA AGAAGCAGGC CCTGCCTCCC TTCCAGCCGC AGATCACCGA TGACTACGGC 1320

CTGGACAATT TTGACACGCA GTTCACCAGC GAGCCCGTGC AGCTGACCCC AGATGATGAG 1380

GACGTCATAA AGAGGATCGA CCAGTCTGAG TTCGAAGGCT TCGAGTACAT CAACCCGCTT 1440

CTGCTGTCCA CCGAGGAGTC CGTGTGA 1467

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 148   FDLIRVIGRGSYAKVLLVRLKKNDQVYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP  207

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqt++rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhe+g

Q: 208   FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG  267

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvllda+Ghikl+d+G+cke++  g+ttstfcGtP+yiaPeil++eeyg+s

Q: 268   IIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS  327

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeaveilkg  233

         vdwwalGvl++em+ag+sPf+       +++ed+lf++ilek +++P+ ls++a+++lkg

Q: 328   VDWWALGVLMFEMMAGRSPFDiitdnpdMNTEDYLFQVILEKPIRIPRFLSVKASHVLKG  387

         **************************999*******************************

S: 234   lltkdpekrlGvk.eegeedikehaff  259

         +l+kdp++rlG++ ++g +dik+haff

Q: 388   FLNKDPKERLGCRpQTGFSDIKSHAFF  414

         ************889***********9

Domain Sequence
(FASTA)

FDLIRVIGRG SYAKVLLVRL KKNDQVYAMK VVKKELVHDD EDIDWVQTEK HVFEQASSNP 60

FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHERG 120

IIYRDLKLDN VLLDADGHIK LTDYGMCKEG LGPGDTTSTF CGTPNYIAPE ILRGEEYGFS 180

VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEDYLFQVIL EKPIRIPRFL SVKASHVLKG 240

FLNKDPKERL GCRPQTGFSD IKSHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013