EKS-ICT-00197

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00197

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	518.5	3.3E-156	4	287	284

Status

Unreviewed

Ensembl Protein

ENSSTOP00000011620

UniProt Accession

I3MK41;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000012968	ENSSTOP00000011620	ENSSTOT00000012967

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

568

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPKGLDY QVVQKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDVWAIGC LVTEMFMGEP LFPGDSDIDQ LYHIMMCLGN LIPRHQELFY KNPVFAGVRL 240

PEIKETEPLE RRYPKLSEVV IDLAKKCLHV DPDKRPFCAE LLHHDFFQMD RFAERFSQEL 300

QLKIQKDARN ISLSKKSQNR KKEKEKDDSL GEERKMLVVQ DTNADPKVKN SKVFKIKGSK 360

IDGEKVEKGN RGSNARYLHE NRISHIKTVP STSLRDCSNV SMNHTRNSST AIPPLTHNLS 420

AVAPGVNSGM GTISGVQSYR VDEKTKKYCI PFVKPNKHSP SGIYNINVTS VSSEKSLLQA 480

NKKRREYSKT DVRLPELNYN HLPELRALEG IARNSRLIKK ENKILSESRI PSLAAIDLHT 540

PSVALHQISG SPLSDDSEAD LPRMEHQH 568

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAGAACCT AGGGTTGGTT GGAGAAGGGA GTTATGGAAT GGTGATGAAA 60

TGTAGGAATA AAGATAGTGG AAGAATTGTG GCCATCAAGA AGTTCTTAGA AAGTGATGAT 120

GACAAAATGG TTAAAAAAAT TGCTATGCGA GAAATCAAGT TACTAAAGCA ATTGAGACAT 180

GAAAATTTGG TGAATCTGTT GGAAGTGTGT AAGAAAAAAA AAAGATGGTA CCTCGTCTTT 240

GAATTTGTTG ACCACACAAT TCTTGATGAC TTGGAACTCT TTCCAAAAGG ATTAGACTAC 300

CAAGTAGTTC AAAAATATTT GTTTCAGATT ATTAATGGAA TTGGATTTTG TCACAGTCAC 360

AATATCATAC ACAGAGATAT AAAGCCAGAG AATATTTTAG TCTCCCAGTC TGGTGTCGTC 420

AAGTTATGTG ACTTTGGATT TGCACGGACT TTGGCTGCTC CAGGAGAGGT TTATACTGAT 480

TATGTGGCAA CTCGCTGGTA CAGAGCTCCA GAACTCTTGG TTGGTGATGT CAAGTACGGC 540

AAGGCTGTTG ATGTGTGGGC CATTGGTTGT CTAGTAACTG AAATGTTCAT GGGAGAACCA 600

CTATTTCCTG GAGATTCAGA TATTGATCAG CTATATCATA TTATGATGTG TTTAGGTAAT 660

TTAATTCCAA GACATCAGGA ATTGTTTTAT AAAAATCCTG TGTTTGCTGG AGTAAGATTG 720

CCTGAAATCA AGGAAACAGA ACCTCTTGAA AGACGCTATC CTAAGCTCTC TGAAGTTGTG 780

ATAGATTTAG CAAAGAAATG CTTACATGTT GACCCAGACA AAAGGCCTTT CTGTGCTGAG 840

CTGCTACACC ATGATTTCTT TCAAATGGAT AGATTTGCGG AGAGGTTTTC TCAGGAACTA 900

CAATTAAAAA TACAGAAAGA TGCCAGGAAT ATTTCTTTAT CTAAAAAATC CCAAAACAGA 960

AAGAAGGAAA AGGAAAAAGA TGATTCCTTA GGTGAAGAAA GAAAAATGCT GGTGGTACAG 1020

GATACCAATG CTGATCCCAA AGTTAAGAAT TCTAAGGTAT TTAAAATAAA AGGATCAAAA 1080

ATCGATGGAG AGAAAGTTGA AAAAGGCAAT AGAGGTTCAA ATGCCAGGTA TCTCCATGAA 1140

AATAGGATAA GCCACATCAA AACAGTGCCT TCCACAAGTC TCAGAGACTG CAGCAATGTC 1200

AGCATGAACC ACACAAGGAA TTCAAGCACA GCAATCCCCC CACTTACACA CAATCTTTCA 1260

GCAGTTGCTC CTGGTGTTAA TTCTGGAATG GGAACTATCT CAGGTGTACA GAGTTACAGA 1320

GTGGATGAGA AAACTAAGAA GTATTGTATT CCATTTGTTA AACCAAATAA ACATTCTCCA 1380

TCAGGAATTT ATAATATTAA TGTGACATCA GTCTCTAGTG AAAAAAGCCT CCTTCAGGCA 1440

AATAAGAAAA GAAGGGAATA TTCTAAGACA GACGTCCGTT TGCCTGAACT GAACTATAAT 1500

CATCTCCCTG AACTAAGAGC CTTGGAAGGA ATAGCTCGAA ATTCTAGACT AATAAAGAAA 1560

GAGAACAAAA TTCTTTCAGA ATCTCGGATT CCTTCTCTGG CTGCTATTGA CCTGCATACT 1620

CCCAGTGTTG CTTTACATCA GATATCAGGA TCTCCCCTGT CAGATGATTC AGAGGCCGAC 1680

TTGCCTCGGA TGGAACACCA GCATTGA 1707

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkd+g+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+le +p+G+++++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTILDDLELFPKGLDYQVVQKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGcl++e+++Geplfpg+sd+dqly+i+++lG+liprhq++f+kn+vfaGv+lpe+

Q: 184   DVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFYKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++e+le++ypkl+ev++dl+kkcl++dp++r +c+ell+h++f

Q: 244   KETEPLERRYPKLSEVVIDLAKKCLHVDPDKRPFCAELLHHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDSGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTILDDLEL FPKGLDYQVV QKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DVWAIGCLVT EMFMGEPLFP GDSDIDQLYH IMMCLGNLIP RHQELFYKNP VFAGVRLPEI 240

KETEPLERRY PKLSEVVIDL AKKCLHVDPD KRPFCAELLH HDFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013