EKS-ICT-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	335.0	3.0E-100	34	292	259

Status

Unreviewed

Ensembl Protein

ENSSTOP00000011958

UniProt Accession

I3MKU0;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000013329	ENSSTOP00000011958	ENSSTOT00000013343

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1241

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPI 300

RELIAEAKAE VTEEVEDGKE EDDDEETENS LPIPASKRAS SDLSIASSEE DKLSQNACIL 360

ESVSEKTERS SSGDNFSSKV LNEKLTTAEA EKAVEGINED TNDAHLEAVS EYHDRPTVIQ 420

DSEREKRLKL ENLPDTEDQA AVGINSVNEG EENNVTVTLE TNNKHNLKQE GEKDQDKQQT 480

LENKFIKSEE MKDSTIQTVD LVSQETGEKE TDIQVVDNEV GLTKEDTPEK LEKDDRTQND 540

MINDNSSKVT NEATNVAEKA VENNIEVVQT NDGKEVVEVA QKVIDKPMEG PEVCGTKDVP 600

PTKEIVETKD VDERSVEVKS EEQLVNSSEN ILETNEEPRT NEVEEVSELS GTEEIEVRSA 660

VIDTEQKAVG SETQDAQEAT AQIETENKEI PREVPIKIEP QVPATSQPSE PQPVSIPSIN 720

INSEDAENKG EIGALSKTET ILLPESENQK ENDTDSGTGS AADNSSIDLN LSISSFLSKT 780

KDSGSISLQE TRRQKKTLKK TRKFIVDGVE VSVTTSKIVT DSDSKTEELR FLRRQELREL 840

RFLQKEEQRA QQQLNSKLQQ QREQIFRRFE QEMMGKKRQY DQEIENLEKQ QKQTIERLEQ 900

EHTNRLRDEA KRIKGEQEKE LSKFQNMLKN RKKEVINEVE KAPKELRKEL MKRRKEELAQ 960

SQHAQEQEFV QKQQQELDGS LKKIIQQQKA ELANIERECL NNKQQLMRAR EAAIWELEER 1020

HLQEKHQLLK QQLKDQYFMQ RHQLLKRHEK ETEQMQRYNQ RLIEELKNRQ TQERARLPKI 1080

QRSEAKTRMA MFKKSLRINS TATPDQDRDK IKQFAAQEEK RQKNERMAQH QKHENQMRDL 1140

QLQCEANVRE LHQLQNEKCH LLVEHETQKL KELDEEHSQE LKEWREKLRP RKKTLEEEFA 1200

RKLQEQEVFF KMTGESECLN PSTQSRISKF YPIPSLHSTG S 1241

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAGCAG 60

TACGAACATG TGAAGAGGGA CCTGAACCCC GAGGAGTTTT GGGAAATTAT AGGAGAACTG 120

GGCGACGGAG CCTTTGGGAA AGTGTACAAG GCACAGAATA AAGAGACCAA TGTTTTAGCA 180

GCTGCAAAGG TGATTGACAC TAAATCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 240

GATATATTAG CATCTTGTGA TCACCCAAAC ATAGTCAAGC TTCTAGATGC TTTCTATTAT 300

GAAAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGTG GAGCAGTAGA TGCTGTGATG 360

CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATACAAG TAGTTTGCAA GCAGACTTTA 420

GAGGCATTGA ACTACTTACA TGATAATAAA ATCATCCATA GAGATCTAAA AGCTGGCAAC 480

ATTCTTTTTA CCTTAGATGG AGATATTAAA TTGGCGGATT TTGGAGTATC AGCTAAAAAC 540

ACAAGGACAA TTCAAAGAAG GGATTCTTTT ATTGGCACTC CATATTGGAT GGCTCCTGAA 600

GTAGTCATGT GTGAGACGTC GAAGGACAGA CCCTATGACT ATAAAGCTGA TGTTTGGTCC 660

CTGGGTATCA CTTTAATAGA AATGGCTGAG ATAGAACCAC CTCATCATGA GTTAAATCCA 720

ATGCGAGTGC TGCTAAAAAT AGCAAAATCT GAACCTCCTA CATTAGCACA GCCATCACGA 780

TGGTCTTCAA ATTTTAAGGA CTTTCTAAAG AAATGCTTGG AAAAGAATGT GGATGCCAGG 840

TGGACTACAT CTCAACTACT GCAGCATCCC TTTGTTACTG TTGATTCCAA TAAACCAATC 900

CGAGAATTGA TAGCAGAAGC AAAGGCTGAA GTAACAGAGG AAGTTGAAGA TGGCAAAGAG 960

GAAGATGATG ATGAGGAAAC AGAAAATTCT CTGCCAATAC CTGCAAGTAA GCGTGCCTCC 1020

TCTGACCTTA GTATTGCCAG TTCAGAAGAA GATAAACTTT CACAAAATGC TTGTATTTTG 1080

GAGTCCGTCT CAGAAAAAAC AGAACGCAGT TCTTCTGGGG ATAATTTTAG CAGCAAAGTT 1140

CTTAATGAAA AACTCACCAC TGCTGAAGCT GAAAAGGCTG TGGAGGGTAT TAATGAAGAT 1200

ACAAATGATG CTCATTTAGA AGCTGTGTCT GAATACCATG ATAGACCAAC AGTAATCCAG 1260

GACAGTGAGA GAGAGAAGAG ACTCAAGTTG GAAAATCTGC CTGACACAGA AGATCAGGCA 1320

GCTGTGGGCA TTAATTCAGT CAATGAAGGA GAAGAGAATA ATGTAACAGT AACTTTAGAA 1380

ACAAATAACA AACATAATTT GAAACAGGAG GGAGAAAAGG ATCAGGATAA ACAACAGACA 1440

CTTGAAAATA AATTTATAAA ATCTGAAGAA ATGAAAGATT CTACTATTCA GACAGTTGAT 1500

TTAGTTTCTC AAGAGACTGG AGAAAAAGAG ACAGATATTC AGGTAGTTGA CAATGAAGTT 1560

GGGCTTACAA AGGAGGACAC CCCAGAGAAA TTGGAAAAAG ATGACAGAAC TCAAAATGAT 1620

ATGATCAATG ATAATAGTAG CAAAGTGACA AATGAGGCAA CAAATGTTGC TGAGAAGGCA 1680

GTTGAAAACA ATATTGAGGT TGTTCAGACT AATGATGGGA AAGAAGTGGT TGAAGTAGCC 1740

CAGAAAGTAA TAGATAAGCC CATGGAAGGT CCTGAGGTTT GTGGTACTAA GGATGTTCCT 1800

CCTACTAAAG AAATAGTTGA GACTAAAGAT GTAGATGAAA GATCTGTAGA AGTTAAAAGT 1860

GAAGAACAAC TAGTCAACAG TTCAGAGAAC ATATTGGAGA CCAATGAAGA ACCAAGGACA 1920

AATGAAGTTG AGGAAGTTAG TGAGTTAAGT GGCACTGAAG AAATAGAGGT CAGAAGTGCA 1980

GTGATTGATA CTGAACAAAA GGCTGTAGGA AGTGAAACTC AGGATGCTCA GGAAGCCACT 2040

GCTCAGATAG AGACAGAGAA TAAAGAAATT CCACGTGAAG TGCCAATTAA AATAGAACCT 2100

CAAGTTCCTG CAACTTCACA GCCCAGTGAA CCTCAGCCTG TTTCAATACC CAGTATTAAT 2160

ATCAACTCTG AAGATGCAGA AAATAAAGGA GAAATAGGTG CTTTATCAAA AACTGAAACC 2220

ATACTGCTAC CAGAATCTGA GAATCAGAAG GAAAATGATA CTGATTCAGG CACTGGTTCC 2280

GCTGCTGATA ATAGCAGCAT TGACTTGAAT TTATCCATCT CTAGCTTCCT AAGTAAAACT 2340

AAAGACAGTG GGTCAATATC TTTACAAGAA ACAAGAAGAC AAAAGAAAAC ATTGAAGAAA 2400

ACACGAAAAT TTATTGTTGA TGGTGTAGAA GTGAGTGTAA CAACATCGAA GATAGTTACA 2460

GACAGTGACT CCAAAACTGA GGAATTGAGG TTTCTCAGAC GTCAGGAACT TCGAGAGTTA 2520

AGATTTCTTC AGAAAGAAGA GCAAAGAGCC CAACAACAGC TCAATAGCAA GCTGCAGCAA 2580

CAACGAGAAC AAATATTCCG GCGCTTTGAG CAAGAAATGA TGGGTAAAAA GCGACAATAT 2640

GACCAGGAAA TTGAGAATCT AGAAAAGCAG CAGAAACAGA CTATTGAACG ACTAGAACAA 2700

GAACACACAA ATCGCCTACG AGATGAAGCC AAACGCATTA AAGGAGAACA AGAAAAAGAG 2760

CTATCCAAAT TTCAGAATAT GCTGAAGAAC CGAAAGAAGG AGGTTATAAA TGAAGTGGAG 2820

AAAGCACCCA AAGAGCTGAG AAAAGAGCTC ATGAAACGCA GGAAAGAGGA GCTTGCACAA 2880

AGCCAGCATG CTCAGGAACA AGAATTTGTT CAGAAGCAAC AACAAGAATT AGATGGCTCT 2940

TTGAAAAAGA TCATCCAACA GCAGAAGGCA GAGTTGGCTA ATATCGAGAG AGAGTGCCTG 3000

AATAACAAAC AGCAGCTCAT GAGAGCTCGA GAAGCTGCAA TTTGGGAGCT TGAAGAACGG 3060

CACTTACAAG AAAAACACCA GCTGCTCAAA CAGCAACTTA AAGATCAGTA TTTCATGCAA 3120

AGACATCAGC TACTGAAGCG CCATGAAAAG GAAACAGAAC AAATGCAGCG TTACAATCAA 3180

CGACTTATTG AGGAATTGAA AAACAGACAG ACTCAAGAAA GAGCGAGGCT GCCCAAGATT 3240

CAGCGTAGTG AAGCCAAGAC TCGAATGGCC ATGTTTAAAA AGAGTTTGAG AATTAACTCA 3300

ACAGCCACAC CAGACCAGGA CCGAGACAAA ATTAAACAGT TTGCTGCACA AGAAGAAAAG 3360

AGGCAGAAAA ATGAGAGAAT GGCTCAACAT CAAAAACATG AAAATCAAAT GCGGGATCTT 3420

CAGTTGCAGT GTGAAGCCAA TGTCCGAGAA TTGCACCAAC TGCAGAATGA AAAATGCCAC 3480

CTGTTGGTTG AGCATGAGAC CCAGAAACTC AAGGAATTAG ATGAAGAACA TAGCCAAGAA 3540

TTAAAGGAAT GGAGAGAGAA ATTGAGACCT AGGAAAAAGA CACTGGAAGA AGAGTTTGCC 3600

AGGAAACTGC AGGAACAGGA AGTATTCTTT AAAATGACTG GGGAGTCGGA ATGCCTTAAC 3660

CCATCAACAC AGAGCCGGAT TTCCAAGTTC TATCCTATTC CTAGCTTGCA TTCCACTGGA 3720

TCATAA 3726

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLEALNYLHDNKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+ae epP+++l+p+++llki+k+epp+l +++++s++fk+f++kc

Q: 213   DYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDARWTTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVYKAQN KETNVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLEAL NYLHDNKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAEIEP PHHELNPMRV LLKIAKSEPP TLAQPSRWSS NFKDFLKKCL 240

EKNVDARWTT SQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013