EKS-ICT-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	508.2	6.2E-153	543	848	306

Status

Unreviewed

Ensembl Protein

ENSSTOP00000012045

UniProt Accession

I3ML08;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS1

Gene Synonyms/Alias

LATS1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000013443	ENSSTOP00000012045	ENSSTOT00000013443

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

968

Protein Sequence
(FASTA)

MKPGSVQQSI NRKQSWKGSK ESLVPQRHGP PLGESVVYRS ESPNSQTDVG RPLSGSGITA 60

FAQAHPSNGQ RVNPPPPPQI RSVTPPPPPR GQTPPPRGTT PPPPSWEPNS QTKRYSGNME 120

YVISRISPVP PGAWQEGYPP PPLNTSPMNP PNQGQRGIGS VPVGRQPIIM QSSNKFNFPP 180

GRPGIQNGGG QTDFMMHQNV VPAGTVNRQP PPPYPLTPAN GQSPSALQTG GSAAPSSYPN 240

GNIPQSMIVP NRNSHNLELY NINIPGLQTN WPQSSSAPAQ SSPSSGHEIP TWQPNIPVRS 300

NSFNNPLGNR TSHSANSQPS ATTVTAITPA PIQQPVKSMR VLKPELQTAL APTHPSWIPQ 360

PIQTVQPSPF SEGTTSNMAV MPPVAEAPNY QGPPPPYPKH LLHQNPSVPP YEPVNKSSKE 420

DQPSLSNEDE GEKNFENVDS GDKEKKQITT SPITVRKNKK DEERRESRIQ SYSPQAFKFF 480

MEQHVENVLK SHQQRLHRKK QLENEMMRVG LSQDAQDQMR KMLCQKESNY IRLKRAKMDK 540

SMFVKIKTLG IGAFGEVCLA RKVDTKALYA TKTLRKKDVL LRNQVAHVKA ERDILAEADN 600

EWVVRLYYSF QDKDNLYFVM DYIPGGDMMS LLIRMGIFPE NLARFYIAEL TCAVESVHKM 660

GFIHRDIKPD NILIDRDGHI KLTDFGLCTG FRWTHDSKYY QSGDHPRQDS MDFSNEWGDP 720

SNCRCGDRLK PLERRAARQH QRCLAHSLVG TPNYIAPEVL LRTGYTQLCD WWSVGVILFE 780

MLVGQPPFLA QTPLETQMKV INWQTSLHIP PQAKLSPEAS DLIIKLCRGP EDRLGKNGAD 840

EIKAHPFFKT IDFSSDLRQQ SASYIPKITH PTDTSNFDPV DPDKLWSDDN EEENVNDTLN 900

GWYKNGKHPE HAFYEFTFRR FFDDNGYPYN YPKPIEYDYI NSQSSEQQSD EDDQQTGSEI 960

KNRDLVYV 968

Nucleotide Sequence
(FASTA)

ATGAAACCAG GGAGTGTGCA ACAATCAATT AACCGTAAAC AAAGCTGGAA AGGCTCTAAA 60

GAATCTTTAG TTCCTCAGAG ACATGGCCCA CCTCTGGGAG AAAGTGTGGT CTACCGTTCT 120

GAAAGTCCCA ACTCACAGAC AGATGTAGGA AGACCTTTAT CTGGATCTGG TATAACAGCA 180

TTTGCTCAAG CTCACCCTAG CAATGGACAG AGAGTGAACC CCCCACCACC ACCTCAAATA 240

AGGAGTGTTA CTCCTCCACC ACCTCCAAGA GGCCAGACTC CCCCTCCACG AGGTACAACT 300

CCACCTCCCC CATCTTGGGA ACCAAACTCT CAAACAAAGA GGTATTCTGG GAACATGGAA 360

TATGTAATCT CCCGAATCTC TCCTGTTCCA CCTGGGGCAT GGCAGGAGGG CTATCCACCA 420

CCACCTCTTA ACACTTCCCC CATGAATCCT CCTAACCAGG GACAGAGAGG TATTGGTTCT 480

GTTCCTGTGG GCAGACAACC AATCATCATG CAGAGTTCTA ACAAATTTAA CTTTCCACCA 540

GGGAGACCTG GAATTCAGAA TGGTGGTGGT CAGACTGACT TTATGATGCA CCAAAATGTT 600

GTCCCTGCTG GCACTGTGAA TCGGCAGCCA CCCCCACCCT ATCCTCTGAC CCCAGCTAAT 660

GGACAAAGCC CTTCTGCTTT ACAAACAGGG GGGTCTGCTG CTCCTTCGTC ATACCCAAAC 720

GGAAATATTC CTCAGTCTAT GATAGTGCCA AACAGAAACA GTCATAACCT GGAACTTTAT 780

AACATTAATA TACCTGGACT GCAGACAAAT TGGCCTCAGT CATCTTCTGC TCCTGCCCAG 840

TCATCCCCAA GCAGCGGGCA TGAGATTCCT ACATGGCAGC CTAACATACC AGTGAGGTCA 900

AATTCGTTTA ATAACCCCTT AGGAAATAGA ACAAGTCACT CTGCTAATTC TCAGCCTTCA 960

GCTACAACAG TCACTGCGAT CACACCAGCT CCCATTCAAC AGCCTGTGAA AAGTATGCGT 1020

GTATTAAAAC CAGAGCTACA GACTGCGTTA GCACCTACCC ACCCTTCTTG GATACCACAA 1080

CCAATTCAGA CTGTTCAACC CAGCCCTTTT TCTGAGGGTA CTACTTCCAA TATGGCTGTT 1140

ATGCCACCTG TTGCTGAAGC TCCAAACTAT CAAGGTCCAC CACCACCTTA TCCAAAACAT 1200

CTGCTACACC AAAACCCATC TGTTCCTCCA TATGAACCTG TAAATAAATC TAGTAAAGAG 1260

GATCAGCCTA GCTTATCCAA TGAAGATGAG GGTGAGAAAA ATTTTGAAAA TGTTGATAGT 1320

GGGGATAAAG AAAAGAAGCA GATTACAACT TCACCTATCA CTGTTAGGAA AAACAAGAAA 1380

GATGAAGAGC GAAGAGAATC TCGTATTCAG AGTTATTCTC CTCAGGCATT TAAATTCTTT 1440

ATGGAGCAGC ATGTAGAAAA TGTCCTCAAA TCTCATCAGC AACGTCTGCA TCGTAAAAAA 1500

CAATTAGAGA ACGAAATGAT GCGGGTTGGA TTATCTCAAG ATGCCCAGGA TCAAATGAGA 1560

AAGATGCTTT GCCAAAAAGA GTCTAACTAC ATTCGTCTTA AAAGGGCTAA AATGGACAAG 1620

TCTATGTTTG TGAAGATAAA GACCCTAGGA ATAGGAGCAT TTGGTGAAGT GTGTCTAGCA 1680

AGAAAAGTAG ATACTAAGGC TTTGTATGCA ACAAAAACTC TTCGAAAGAA AGATGTTCTA 1740

CTTCGAAATC AAGTCGCACA TGTTAAAGCT GAGAGAGATA TACTGGCTGA AGCTGACAAT 1800

GAATGGGTAG TTCGCTTATA TTATTCATTC CAAGATAAGG ACAATTTATA CTTTGTGATG 1860

GATTACATTC CCGGGGGTGA TATGATGAGC CTCTTAATTA GAATGGGCAT CTTTCCAGAA 1920

AATCTGGCAC GGTTCTACAT AGCAGAACTT ACTTGTGCAG TCGAAAGTGT TCATAAAATG 1980

GGTTTTATTC ATAGGGATAT TAAGCCTGAT AACATTTTGA TTGATCGTGA TGGTCATATT 2040

AAATTGACTG ACTTCGGCCT TTGCACTGGC TTCAGATGGA CACATGATTC CAAGTACTAT 2100

CAAAGTGGAG ACCATCCTCG GCAAGATAGC ATGGACTTTA GTAATGAATG GGGTGATCCC 2160

TCAAATTGTC GATGTGGAGA TAGATTAAAG CCATTAGAGC GGAGAGCTGC ACGCCAGCAC 2220

CAGCGATGTC TAGCACATTC TTTGGTTGGG ACTCCCAATT ATATTGCACC TGAAGTATTG 2280

CTGCGAACAG GATATACACA GTTATGTGAT TGGTGGAGTG TTGGTGTTAT TCTTTTTGAA 2340

ATGTTGGTGG GACAGCCTCC TTTCTTGGCA CAGACACCAT TAGAAACACA AATGAAGGTT 2400

ATCAATTGGC AGACATCTCT TCACATTCCT CCACAAGCTA AACTGAGTCC AGAAGCCTCT 2460

GATCTGATCA TTAAACTTTG CCGAGGACCA GAAGATCGCT TAGGGAAGAA TGGTGCTGAT 2520

GAAATAAAAG CTCATCCATT TTTTAAAACA ATTGATTTTT CCAGTGATCT GAGACAGCAG 2580

TCTGCTTCAT ACATTCCTAA AATCACACAC CCAACAGATA CATCAAATTT TGATCCTGTT 2640

GATCCTGATA AGTTATGGAG TGATGATAAT GAGGAAGAAA ATGTAAATGA TACTCTCAAC 2700

GGATGGTACA AAAATGGAAA GCACCCTGAA CATGCTTTCT ATGAGTTTAC CTTTCGAAGG 2760

TTTTTTGATG ACAATGGCTA CCCATACAAT TATCCAAAGC CTATTGAATA TGACTACATT 2820

AATTCACAAA GCTCAGAGCA ACAGTCGGAT GAAGATGATC AGCAAACAGG CTCAGAGATT 2880

AAAAATCGTG ATCTAGTGTA TGTTTAA 2907

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew

Q: 543   FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  602

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf

Q: 603   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  662

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+

Q: 663   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNewgdpsn  722

         ***************************************************999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml

Q: 723   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  782

         ************************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei

Q: 783   VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  842

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 843   KAHPFF  848

         *****9

Domain Sequence
(FASTA)

FVKIKTLGIG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60

VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120

IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSNEWGDPSN 180

CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240

VGQPPFLAQT PLETQMKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013