EKS-ICT-00260

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00260

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.4	1.6E-140	177	464	288

Status

Unreviewed

Ensembl Protein

ENSSTOP00000012159

UniProt Accession

I3ML93;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000013570	ENSSTOP00000012159	ENSSTOT00000013570

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

ALQCFCHLCT KDNFTCVTDG LCFVSVTETT DKVIHNSMCI AEIDLIPRDR PFVCAPSSKT 60

GSVTTTYCCN QDHCNKIELP TTGPFSVKQS PGLGPVELAA VIAGPVCFVC ISLMLMVYIC 120

HNRTVIHHRV PNEEDPSLDR PFISEGTTLK DLIYDMTTSG SGSGLPLLVQ RTIARTIVLQ 180

ESIGKGRFGE VWRGKWRGEE VAVKIFSSRE ERSWFREAEI YQTVMLRHEN ILGFIAADNK 240

DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT VEGMIKLALS TASGLAHLHM EIVGTQGKPA 300

IAHRDLKSKN ILVKKNGTCC IADLGLAVRH DSATDTIDIA PNHRVGTKRY MAPEVLDDSI 360

NMKHFESFKR ADIYAMGLVF WEIARRCSIG GIHEDYQLPY YDLVPSDPSV EEMRKVVCEQ 420

KLRPNIPNRW QSCEALRVMA KIMRECWYAN GAARLTALRI KKTLSQLSQQ EGIKM 475

Nucleotide Sequence
(FASTA)

GCACTACAGT GTTTCTGCCA CCTCTGTACA AAAGATAATT TTACCTGTGT GACAGATGGG 60

CTTTGCTTTG TCTCTGTCAC AGAGACCACA GACAAAGTTA TACATAATAG CATGTGTATA 120

GCTGAAATTG ACCTAATTCC TCGAGATAGA CCATTTGTAT GTGCACCCTC TTCAAAAACT 180

GGGTCTGTTA CTACAACATA TTGTTGCAAT CAGGACCACT GCAATAAAAT AGAGCTCCCA 240

ACTACTGGCC CTTTTTCAGT AAAGCAGTCT CCTGGCCTTG GCCCCGTCGA GCTGGCAGCT 300

GTCATTGCTG GACCGGTCTG CTTCGTCTGC ATCTCACTCA TGTTGATGGT CTATATCTGC 360

CATAACCGTA CTGTCATTCA CCATCGAGTG CCAAATGAAG AGGATCCTTC ATTAGATCGC 420

CCTTTTATTT CAGAGGGTAC TACATTAAAA GATTTAATTT ATGATATGAC AACATCAGGG 480

TCTGGATCAG GTTTACCATT GCTTGTTCAG AGAACAATTG CAAGAACTAT TGTGTTACAA 540

GAAAGTATTG GCAAAGGTCG ATTTGGAGAA GTTTGGCGAG GAAAGTGGCG GGGAGAAGAA 600

GTTGCCGTTA AGATATTCTC CTCCAGAGAA GAACGTTCAT GGTTCCGCGA GGCAGAAATT 660

TATCAAACTG TAATGTTGCG CCATGAAAAC ATCCTGGGAT TTATAGCAGC AGACAATAAA 720

GACAATGGTA CATGGACTCA GCTCTGGCTG GTGTCAGATT ATCATGAGCA TGGATCCCTT 780

TTTGATTACT TGAACAGATA TACAGTTACT GTGGAAGGAA TGATCAAACT CGCTCTGTCC 840

ACAGCAAGCG GTCTTGCCCA TCTTCACATG GAGATTGTTG GTACCCAAGG AAAACCAGCT 900

ATTGCTCATA GAGATTTGAA ATCAAAGAAT ATCTTGGTGA AGAAGAATGG AACATGCTGT 960

ATTGCAGACT TAGGACTGGC AGTAAGACAT GATTCAGCCA CAGATACAAT TGATATTGCT 1020

CCAAACCACA GAGTGGGAAC AAAAAGGTAC ATGGCCCCTG AAGTTCTAGA TGATTCCATA 1080

AATATGAAAC ATTTTGAATC CTTCAAACGT GCTGACATCT ATGCAATGGG CTTAGTGTTC 1140

TGGGAAATTG CTCGACGATG TTCCATTGGT GGAATTCATG AAGATTACCA GCTGCCTTAT 1200

TATGATCTTG TACCTTCTGA TCCGTCAGTT GAAGAAATGA GAAAAGTAGT TTGTGAACAG 1260

AAATTAAGGC CAAATATTCC AAACAGATGG CAGAGCTGTG AAGCCTTGAG AGTGATGGCT 1320

AAAATCATGA GAGAATGTTG GTATGCCAAT GGAGCAGCTA GGCTGACAGC CTTACGGATT 1380

AAGAAGACAT TGTCACAACT CAGTCAACAG GAAGGCATCA AAATGTAA 1428

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 177   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  236

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 237   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  296

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 297   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  354

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 355   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  413

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 414   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  464

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013