EKS-ICT-00008
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00008
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph502.51.7E-151615874260
StatusUnreviewed
Ensembl ProteinENSSTOP00000012314
UniProt AccessionI3MLL6;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4
Gene Synonyms/Alias EPHB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000013737ENSSTOP00000012314ENSSTOT00000013743
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length987
Protein Sequence
(FASTA)
MELRALLCWA SLTAALEETL LNTKLETADL KWVTFPQVEG QWEELSGLDE EQHSVRTYEV 60
CDLQRAPGLA HWLRTGWVPR RGAVHVYATL RFTMLECLSL PRAGRSCKET FTVFYYESDA 120
DTATALTPAW MENPYIKVDT VAAEHLTRKR PGAEATGKVN VKTLRLGPLS KAGFYLAFQD 180
QGACMALLSL HLFYKKCPPL TVNLTHFPGT VPRELVVPVA GSCVADAVPA PGPSPSLYCR 240
EDGQWAEQPV IGCNCNPGFE ATEGNTKCRA CGQGTFKPES GEGSCQPCPA NSHSNTIGSS 300
VCQCRIGYYR ARADPQGAPC TTPPSAPRSV VPHLNGSSLH LEWSAPLESG GRDDLTYALR 360
CRECRPGGSC LPCGGDLTFD PGPRDLVEPW VAIRGLRPDF TYTFEVTALN GVSSLATGPV 420
PFEPVNVTTD REVPPAVSDI RVTRSSPSSL SLAWAVPRAP SGAVLDYEVK YHEKGAEGPS 480
SVRFLKTSEN RAELRGLKRG ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE SESWREQLAL 540
IAGTAVVGVV LVLVVIVIAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN 600
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK GGYTERQRRE 660
FLSEASIMGQ FEHPNIIRLE GVVTNSVPVM ILTEFMENGA LDSFLRLNDG QFTVIQLVGM 720
LRGIASGMRY LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG 780
KIPIRWTAPE AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP 840
PPPDCPTSLH QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD 900
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISAEDLLRI GVTLAGHQKK 960
ILASVQHMKS QAKPGAPGGT GGQAPQY 987
Nucleotide Sequence
(FASTA)
ATGGAGCTCC GGGCGCTGCT CTGCTGGGCT TCGCTCACCG CCGCTTTAGA AGAGACTTTA 60
CTGAACACAA AATTGGAAAC TGCCGATCTG AAGTGGGTGA CATTCCCTCA GGTGGAGGGC 120
CAGTGGGAGG AGCTGAGCGG CCTGGACGAG GAGCAGCACA GTGTGCGCAC GTATGAGGTG 180
TGCGACCTGC AGCGAGCCCC AGGCCTGGCT CACTGGCTGC GGACGGGCTG GGTCCCTCGT 240
CGTGGCGCTG TGCACGTGTA CGCCACGCTG CGCTTCACCA TGCTCGAGTG CCTGTCTCTG 300
CCGCGGGCTG GCCGCTCCTG CAAGGAGACT TTCACCGTCT TCTACTATGA GAGCGATGCA 360
GACACAGCCA CAGCCCTCAC GCCGGCCTGG ATGGAGAACC CCTACATCAA GGTGGACACA 420
GTGGCTGCGG AGCATCTCAC AAGGAAGCGC CCTGGGGCTG AGGCGACTGG GAAGGTGAAC 480
GTCAAGACGC TGCGTCTGGG CCCGCTCAGC AAGGCCGGCT TCTACCTGGC CTTCCAGGAC 540
CAGGGCGCCT GCATGGCCCT GCTGTCACTG CACCTCTTTT ACAAGAAGTG CCCCCCACTG 600
ACGGTGAACC TGACCCACTT CCCAGGGACT GTGCCTCGGG AGCTTGTGGT GCCTGTGGCT 660
GGGAGCTGTG TAGCAGACGC TGTCCCTGCC CCTGGCCCCA GCCCCAGCCT CTACTGTCGA 720
GAGGATGGCC AGTGGGCCGA GCAGCCGGTC ATCGGCTGCA ACTGTAACCC AGGGTTCGAG 780
GCCACCGAGG GGAACACAAA GTGCCGAGCC TGTGGCCAGG GCACCTTCAA GCCCGAGTCA 840
GGAGAGGGGT CCTGCCAGCC ATGTCCGGCC AATAGCCATT CTAACACCAT CGGGTCCTCT 900
GTCTGCCAGT GCCGCATTGG GTACTACCGG GCCCGTGCGG ACCCCCAAGG CGCACCCTGC 960
ACCACCCCTC CTTCTGCTCC AAGAAGTGTG GTTCCCCATC TGAATGGCTC CTCCCTGCAC 1020
CTGGAATGGA GTGCGCCCCT CGAGTCTGGC GGCCGGGACG ACCTCACCTA TGCACTTCGC 1080
TGCCGAGAGT GTCGTCCAGG GGGGTCCTGC CTGCCCTGTG GGGGAGACCT GACCTTTGAC 1140
CCCGGCCCCC GGGACCTGGT GGAGCCCTGG GTGGCTATTC GAGGGCTGCG TCCTGACTTC 1200
ACCTATACTT TTGAGGTCAC TGCCTTGAAT GGCGTGTCCT CTTTAGCCAC AGGGCCTGTC 1260
CCATTTGAGC CTGTCAACGT CACCACCGAC CGGGAGGTGC CCCCTGCAGT GTCTGACATC 1320
CGTGTGACAC GGTCATCACC CAGCAGTTTG AGCTTGGCAT GGGCTGTGCC GCGAGCGCCC 1380
AGTGGGGCTG TTCTGGACTA CGAGGTCAAG TACCATGAGA AGGGTGCAGA GGGCCCAAGC 1440
AGTGTACGGT TTTTAAAGAC CTCAGAAAAC CGCGCTGAGC TTCGGGGGCT GAAGCGGGGA 1500
GCCAGCTACC TTGTCCAGGT GCGGGCACGC TCTGAGGCCG GCTATGGGCC CTTTGGCCAG 1560
GAACATCACA GTCAGACCCA GCTGGATGAG AGTGAGAGCT GGCGGGAGCA GCTGGCCCTG 1620
ATAGCAGGCA CAGCGGTCGT TGGTGTGGTC CTGGTCCTGG TGGTCATTGT CATTGCTGTC 1680
CTCTGCCTCA GGAAGCAGAG CAACGGGAGG GAGGCCGAAT ACTCGGACAA ACACGGGCAG 1740
TATCTCATCG GGCATGGTAC GAAGGTCTAC ATTGACCCCT TCACATATGA AGACCCCAAT 1800
GAGGCTGTGA GGGAGTTTGC CAAAGAGATC GACGTCTCCT ATGTGAAGAT TGAGGAGGTG 1860
ATAGGTGCAG GCGAGTTTGG TGAGGTGTGC CGGGGGCGAC TGAAGGCCCC TGGGAAGAAG 1920
GAGAGCTGTG TGGCCATCAA GACCCTAAAG GGGGGCTACA CCGAACGGCA GCGGCGGGAG 1980
TTCCTGAGCG AGGCCTCCAT CATGGGCCAG TTTGAGCACC CCAACATCAT CCGCCTGGAG 2040
GGCGTGGTCA CCAACAGCGT GCCCGTCATG ATCCTCACTG AGTTCATGGA GAACGGAGCC 2100
CTGGACTCTT TCCTTCGGCT GAACGACGGG CAGTTTACGG TCATCCAGCT GGTGGGCATG 2160
TTGCGGGGCA TTGCCTCTGG CATGCGGTAC CTTGCTGAGA TGAGCTATGT CCACCGAGAC 2220
CTGGCTGCCC GCAACATCCT GGTCAACAGC AACCTAGTCT GCAAGGTCTC TGACTTTGGC 2280
CTTTCCCGAT TCCTGGAGGA GAACTCTTCT GATCCCACCT ATACGAGCTC TCTGGGAGGA 2340
AAGATTCCCA TCCGTTGGAC GGCCCCTGAG GCCATTGCCT TCCGAAAGTT CACATCTGCC 2400
AGCGACGCCT GGAGCTATGG GATTGTGATG TGGGAGGTGA TGTCTTTTGG GGAACGGCCC 2460
TACTGGGACA TGAGCAATCA GGACGTGATC AATGCCATTG AGCAGGACTA TCGGCTGCCC 2520
CCGCCCCCAG ACTGCCCCAC CTCCCTCCAC CAGCTCATGC TGGACTGTTG GCAGAAGGAT 2580
CGGAATGCCC GGCCCCGCTT CCCCCAGGTG GTCAGCGCCC TCGACAAGAT GATCCGGAAC 2640
CCTGCCAGCC TCAAAATCGT GGCCAGGGAG AATGGCGGTG CCTCGCACCC TCTCCTGGAT 2700
CAGCGGCAGC CTCACTACTC GGCTTTTGGC TCTGTGGGAG AATGGCTTCG AGCCATCAAG 2760
ATGGGGAGAT ACGAAGAAAG TTTTGCAGCA GCTGGGTTTG GCTCTTTCGA GCTGGTCAGC 2820
CAGATCTCCG CCGAGGATCT GCTCCGAATT GGAGTCACTC TGGCTGGACA CCAGAAGAAA 2880
ATCTTGGCCA GTGTCCAGCA TATGAAGTCC CAAGCCAAGC CTGGAGCTCC GGGTGGGACA 2940
GGAGGACAAG CCCCTCAGTA TTGA 2964
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e++vaiktlk+g+te+qrr+flseasi+Gqf+hp
Q: 615   VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHP  674
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+s pvmi+te+mengaldsflr +dgqftviqlvgmlrGiasgm+yl++m
Q: 675   NIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM  734
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+le++s +++yt+s ggkipirwtapeaia+
Q: 735   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSsDPTYTSSlGGKIPIRWTAPEAIAF  794
         *******************************99988*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasd+wsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp++l+qlml
Q: 795   RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLML  854
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f q+vs+l
Q: 855   DCWQKDRNARPRFPQVVSAL  874
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KAPGKKESCV AIKTLKGGYT ERQRREFLSE ASIMGQFEHP 60
NIIRLEGVVT NSVPVMILTE FMENGALDSF LRLNDGQFTV IQLVGMLRGI ASGMRYLAEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDAW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPD CPTSLHQLML 240
DCWQKDRNAR PRFPQVVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00008
EKS-BOT-00007
EKS-CAJ-00008
EKS-CAF-00009
EKS-CAP-00006
EKS-DAR-00013
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-LAC-00014
EKS-LOA-00009
EKS-MAM-00007
EKS-MOD-00008
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-NOL-00008
EKS-ORN-00012
EKS-ORA-00007
EKS-ORC-00008
EKS-ORL-00012
EKS-OTG-00009
EKS-PAT-00009
EKS-POA-00006
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-SUS-00006
EKS-TEN-00011
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013