EKS-ICT-00325

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00325

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	289.1	3.6E-86	270	541	272

Status

Unreviewed

Ensembl Protein

ENSSTOP00000012442

UniProt Accession

I3MLV8;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK2

Gene Synonyms/Alias

EIF2AK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000013886	ENSSTOP00000012442	ENSSTOT00000013889

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

556

Protein Sequence
(FASTA)

MANIISRGFF IEELNKYRQK YQVVLKYQEL ATTGPPHDLR FTFQVIIDER KFPEAEGKSK 60

QEAKNAAAKI AVDILNKENK TVSPLSLATT DTSEGSPPGN YIGLVNRISQ KERLNVNYEE 120

CELGEQDPKK FKYKCKIGKK VYGIGIGSTK QEAKQLAAKC ALQKLSEESP MKTDLVPSAA 180

FVSPGNVNNC GSTGSTMSSS LSEPLSEKDS SSDDWTNVQS SENLDSSGSS SMNGLSSNKK 240

KKKISLAAKF DSYNVEENQY TVDHRFAKDF KDIEPIGKGG FGQVFKAKHK IDGNTYVVKR 300

VMYNNKKVER EVQALATFKH PNIVHYCSCW EGDDFYEDPE SSASYPRVSV LYSCHSVNFI 360

SRIKTKCLFI QMELCDKGTL NEWIENRRQK VPDKALALEL FEQIAEGVHY IHSKDLIHRD 420

LKPSNIFLVG EKQIKIGDFG LVTTLKNDEL RTREKGTRRY MSPEQISSEE YGKEVDIFAL 480

GLILAELLYI CPTVSETLKI FEDLRNGIFP DVFDIKEKSL LQKLLSKEPQ KRPDTSKILK 540

TLAKWKDVSE RKRNTY 556

Nucleotide Sequence
(FASTA)

ATGGCAAACA TTATCTCACG AGGTTTCTTC ATAGAAGAAC TTAATAAGTA CCGTCAGAAG 60

TATCAAGTAG TTCTTAAGTA CCAAGAACTG GCTACAACAG GACCTCCCCA TGATTTAAGG 120

TTTACGTTTC AAGTTATAAT AGATGAGAGA AAATTTCCAG AAGCTGAAGG CAAATCAAAG 180

CAGGAAGCAA AAAATGCTGC AGCCAAAATA GCTGTTGATA TACTTAATAA AGAAAACAAG 240

ACAGTTAGTC CTTTATCCTT GGCGACAACA GATACTTCAG AAGGATCACC CCCTGGGAAT 300

TATATAGGAC TTGTCAATAG GATTTCCCAG AAGGAAAGAC TAAATGTAAA TTATGAAGAA 360

TGTGAATTGG GGGAGCAGGA TCCCAAAAAA TTTAAGTATA AATGCAAAAT TGGGAAGAAA 420

GTATATGGTA TCGGTATAGG TTCCACTAAG CAAGAAGCAA AACAATTGGC TGCTAAATGT 480

GCACTTCAGA AACTATCAGA AGAAAGCCCA ATGAAAACTG ACCTAGTACC CTCTGCCGCT 540

TTTGTCAGTC CTGGTAATGT CAATAACTGC GGAAGCACAG GAAGCACAAT GAGTTCATCT 600

TTGTCTGAGC CACTCTCTGA AAAGGACTCC TCATCAGATG ACTGGACAAA TGTTCAGAGC 660

AGTGAGAATT TAGACAGTTC TGGATCTTCT TCTATGAATG GTCTCAGTAG TAATAAAAAG 720

AAGAAAAAAA TAAGTTTGGC AGCTAAATTT GACTCTTATA ACGTAGAAGA AAACCAGTAT 780

ACTGTGGACC ACAGGTTTGC CAAGGATTTT AAAGATATAG AACCAATTGG CAAAGGTGGA 840

TTTGGCCAAG TTTTCAAAGC AAAACACAAA ATAGATGGAA ATACTTACGT TGTTAAACGT 900

GTCATGTATA ATAACAAGAA GGTAGAGCGT GAAGTACAAG CACTGGCCAC ATTTAAACAT 960

CCCAACATTG TTCATTACTG CAGTTGTTGG GAAGGAGATG ATTTTTATGA GGATCCTGAA 1020

AGCAGCGCAA GTTATCCTAG AGTTTCTGTC CTATATAGTT GTCATTCTGT GAATTTTATA 1080

TCCAGAATAA AGACCAAGTG CCTTTTTATC CAAATGGAAT TGTGTGATAA AGGGACATTG 1140

AATGAATGGA TTGAAAATAG AAGACAAAAA GTACCAGACA AAGCTTTGGC TTTGGAATTA 1200

TTTGAACAGA TAGCAGAAGG AGTGCATTAT ATACATTCAA AAGATTTAAT TCATAGAGAC 1260

CTCAAACCAA GTAATATATT TTTAGTAGGT GAAAAACAAA TAAAGATTGG AGACTTTGGA 1320

CTTGTAACAA CCCTGAAGAA TGATGAACTG CGAACAAGAG AAAAGGGAAC TCGGCGATAT 1380

ATGAGCCCAG AACAGATTTC TTCAGAAGAA TACGGAAAGG AAGTAGACAT CTTTGCTTTG 1440

GGGCTAATTC TTGCTGAACT TCTTTACATA TGTCCCACAG TTTCAGAAAC ACTCAAGATT 1500

TTTGAAGATC TAAGAAATGG CATCTTCCCT GATGTATTTG ACATCAAAGA AAAAAGTCTT 1560

CTACAGAAAT TACTCTCAAA GGAACCTCAG AAACGACCTG ACACGTCTAA AATACTGAAG 1620

ACCTTGGCCA AGTGGAAGGA TGTCTCAGAG AGAAAAAGAA ACACATATTA G 1671

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         f++i+ +GkGgfg+V+kak+k+d+++y +kr+++n+     +kverev+aLa ++hpniv

Q: 270   FKDIEPIGKGGFGQVFKAKHKIDGNTYVVKRVMYNN-----KKVEREVQALATFKHPNIV  324

         678999*****************************9.....57*****************

S: 61    rYfaawleek..eesltd..sseveaeaeleesesseesdtkllyiqmelceketLkdwi  116

         +Y ++w+ ++  e++ ++     v+  ++ ++++  ++ +tk+l+iqmelc+k tL++wi

Q: 325   HYCSCWEGDDfyEDPESSasYPRVSVLYSCHSVNFISRIKTKCLFIQMELCDKGTLNEWI  384

         ******9875322333332255677778888899999***********************

S: 117   derkllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLata  176

         ++r+ +   + l ++lf+q++eg++y+Hsk liHrdLkpsniFl  ++q+KigDFgL+t+

Q: 385   ENRRQKVPDKALALELFEQIAEGVHYIHSKDLIHRDLKPSNIFLVGEKQIKIGDFGLVTT  444

         ***77777777777**********************************************

S: 177   laealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypf  236

         l++++              +t++ gt++ymsPeq+++++Y+k+vDif+LGlil+eLly +

Q: 445   LKNDEL-------------RTREKGTRRYMSPEQISSEEYGKEVDIFALGLILAELLYIC  491

         888855.............49***************************************

S: 237   stemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellks  289

          t +e+ +++++lr+g +p+ fd    kek+llqklls++p++Rp++s++lk+

Q: 492   PTVSETLKIFEDLRNGIFPDVFDI---KEKSLLQKLLSKEPQKRPDTSKILKT  541

         ***********************9...9**********************986

Domain Sequence
(FASTA)

FKDIEPIGKG GFGQVFKAKH KIDGNTYVVK RVMYNNKKVE REVQALATFK HPNIVHYCSC 60

WEGDDFYEDP ESSASYPRVS VLYSCHSVNF ISRIKTKCLF IQMELCDKGT LNEWIENRRQ 120

KVPDKALALE LFEQIAEGVH YIHSKDLIHR DLKPSNIFLV GEKQIKIGDF GLVTTLKNDE 180

LRTREKGTRR YMSPEQISSE EYGKEVDIFA LGLILAELLY ICPTVSETLK IFEDLRNGIF 240

PDVFDIKEKS LLQKLLSKEP QKRPDTSKIL KT 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0003725	; F:double-stranded RNA binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001159	; Ds-RNA-bd.
IPR014720	; dsRNA-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00035	; dsrm; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00358

; DSRM; 2.

Prosites

PS50137	; DS_RBD; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013