EPS-ICT-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ICT-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	142.9	1.4E-41	404	560	157

Status

Unreviewed

Ensembl Protein

ENSSTOP00000013035

UniProt Accession

I3MN53;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000014540	ENSSTOP00000013035	ENSSTOT00000014549

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1293

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA AGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDL 60

GSGREYALKR LLSNEEEKNR AIIQEVCFLK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLTELCRGQL VEFLKRVESK GPLSCDTILK IFYQTCRAVQ HMHRQKPPVI HRDLKVENLL 180

LSNQGTIKLC DFGSATTISH YPDYSWSAQK RAMVEEEITR NTTPMYRTPE IVDLYSNFPI 240

GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPG DDSRYTIFHS LIRAMLRVNP 300

EERLSITEVV RQLQEMAAAR NLNPKAPITE LLEQNGGCGN PGPSRVPPPA GGPVSCGYSL 360

ALAEYDQPHG GLLDILRGGT ERLFTNLKDT SSKVIQSVAN YAKGDLDISY ITSRIAVMSF 420

PAEGVESAIK NNIEDVRLFL DAKHPGHYAV YNLSPRTYRA SKFHNRVSEC GWAARRAPHL 480

HSLYTTCRNM HSWLRQDHRN VCVVHCMDGK AASAVAVCAF LCFCRLFSTA EAAVYMFSMK 540

RCPPGIWPSH KRYIEYVCDM VAEEPITPHS KPMLVKAVVM TPVPLFSKQR SGCRPFCEVY 600

VGDERVATTS QEYDRMREFR SEDGKAVIPL GTTVQGDVLL IIYHARSTLG GRLQAKMASM 660

KMFQIQFHTG FVPRNATTVK FAKYDLDACD IQEKYPDLFQ VSLDVEVEPK DRPSRVAPPW 720

DSTSMRGLNP KILFSSREEQ QDILSKFGKP ELPRQPGSTA QYEAEVGSPE AEPSESDSPQ 780

SSGTDASHFL HTLDWQEEKE AETGVENSSP KESPSAPVAD GEGSEASDEE QQTFPGEDTP 840

GLAAGTDQGD LTLQVGSSVA PQEPLPQEEG VDLLGLHSEV DPGPAPPSQA PSSNADLLSR 900

LLGAPNGTPE GPPDDLLLAS PTPPRSTQST LPGGPPSPAD PFDPLRPPAD SSSQPCTAPD 960

LLGELLGPDS TAAAASPVFP ATHSAPPPSC NATFLHLGGL PTEPSKVTAS SSHPDLLGGW 1020

DTWAEAAVPT PAPMSAAEGP LFSPGGQPTP PGLQPSQTKP QSLDPFADLG DLSSGLQGPP 1080

AGFPPGGFTP KSAPSPKGSS WQMNRPPAQG TSWPPQAKPP PKACMQSRPP YATNFSVIGG 1140

REERGIRAPS FAQKPKVSEN DFEDLLSNQG FSSKSDRKGP KTMAEMRKQD LVRDADPLKL 1200

KLLDWIEGKE RNIRALLSTL HTVLWDGESR WTPVSMADLV TPAQVKKQYR RAVLVVHPDK 1260

ATGQPYEQHA KMIFMELNDA WSEFENQGSR PLF 1293

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TGCAGTCCGC GCTCGACTTC CTGGCGGGCC CGGGCTCCCT GGGCGGAGCT 60

GCCGGCCGCG ACCAGAGCGA CTTCGTGGGG CAGACGGTGG AGCTGGGCGA GCTGCGCCTG 120

CGGGTGCGGC GGGTCCTGGC CGAGGGAGGA TTTGCATTTG TATACGAAGC TCAAGACCTG 180

GGAAGTGGCA GAGAGTATGC ATTGAAGAGG TTACTGTCCA ACGAAGAGGA AAAGAACAGA 240

GCCATCATTC AGGAAGTTTG CTTCTTGAAG AAACTTTCTG GCCACCCCAA CATCGTCCAG 300

TTCTGCTCTG CAGCATCCAT AGGAAAAGAG GAGTCGGACA CTGGGCAGGC CGAATTCCTC 360

CTGCTCACGG AGCTCTGTAG AGGGCAGCTG GTGGAATTTC TAAAGAGAGT TGAATCTAAA 420

GGCCCTCTGT CCTGTGACAC CATTCTGAAG ATCTTTTACC AGACGTGCAG AGCAGTGCAG 480

CACATGCACA GACAGAAGCC ACCTGTCATC CACAGAGACC TCAAGGTTGA GAACTTATTG 540

CTTAGCAACC AGGGGACCAT TAAGCTGTGT GACTTTGGCA GTGCCACAAC CATCTCGCAT 600

TACCCTGACT ACAGCTGGAG CGCCCAGAAG CGAGCAATGG TGGAGGAGGA GATCACGAGG 660

AACACCACAC CCATGTACAG AACCCCAGAA ATCGTAGACC TGTACTCCAA CTTCCCCATC 720

GGAGAGAAGC AGGACATCTG GGCCCTGGGC TGCATCCTGT ACCTGCTGTG TTTCCGGCAG 780

CACCCTTTTG AGGATGGTGC AAAGCTTCGC ATAGTCAACG GGAAGTACTC GATCCCCGGG 840

GACGACTCTC GGTACACCAT CTTCCACAGC CTCATTCGTG CCATGCTGAG GGTCAACCCT 900

GAGGAGCGGC TGTCCATCAC AGAGGTGGTC CGCCAACTGC AGGAGATGGC CGCAGCCAGG 960

AATCTGAACC CCAAGGCACC CATCACGGAG CTGCTGGAGC AGAATGGAGG CTGTGGGAAC 1020

CCAGGGCCAT CCCGAGTGCC ACCCCCCGCC GGAGGCCCTG TGAGCTGTGG CTACAGCCTG 1080

GCACTGGCTG AGTACGACCA GCCTCACGGT GGGCTCCTGG ACATCCTGCG GGGTGGGACC 1140

GAGCGACTCT TCACTAACCT CAAGGACACC TCCTCCAAGG TCATCCAGTC TGTTGCTAAC 1200

TATGCCAAGG GTGACCTGGA TATATCCTAC ATCACATCTA GAATTGCTGT GATGTCCTTC 1260

CCAGCTGAAG GCGTGGAGTC AGCCATCAAG AATAACATTG AGGACGTGCG GCTGTTCCTG 1320

GACGCCAAGC ACCCAGGGCA CTACGCTGTC TACAACTTGT CCCCACGAAC CTACCGGGCC 1380

TCCAAGTTCC ACAACCGGGT CTCTGAGTGC GGCTGGGCAG CCAGGCGGGC CCCACACCTG 1440

CACAGCCTGT ACACCACCTG CAGGAACATG CACTCCTGGC TGCGGCAGGA CCACAGGAAC 1500

GTCTGTGTTG TGCACTGTAT GGATGGGAAA GCTGCGTCCG CTGTGGCTGT GTGCGCCTTC 1560

CTGTGCTTCT GCCGTCTCTT CAGCACTGCA GAGGCCGCCG TGTACATGTT CAGCATGAAG 1620

CGCTGTCCGC CAGGCATTTG GCCATCTCAC AAAAGGTACA TCGAGTACGT GTGTGACATG 1680

GTGGCGGAGG AGCCCATCAC GCCGCACAGC AAGCCGATGC TGGTGAAGGC TGTTGTCATG 1740

ACTCCCGTTC CCCTGTTCAG CAAGCAGAGA AGCGGCTGCA GACCCTTCTG CGAGGTCTAC 1800

GTGGGGGACG AGCGCGTGGC CACCACATCC CAGGAGTATG ACAGGATGCG GGAGTTCAGG 1860

AGCGAGGACG GCAAGGCGGT CATCCCCCTG GGCACAACGG TGCAAGGGGA CGTGCTCCTC 1920

ATCATTTACC ATGCCAGGTC CACACTGGGG GGCCGGCTGC AGGCCAAGAT GGCCTCCATG 1980

AAGATGTTCC AGATTCAGTT CCACACTGGC TTCGTGCCTC GGAACGCCAC CACCGTGAAA 2040

TTTGCAAAGT ACGACCTGGA CGCATGTGAC ATCCAAGAGA AGTACCCAGA CCTGTTCCAG 2100

GTGAGCCTGG ACGTTGAGGT GGAGCCCAAG GACAGGCCGA GCCGGGTGGC CCCGCCATGG 2160

GACAGCACCA GCATGAGGGG GCTGAACCCC AAGATCCTGT TCTCCAGCCG GGAGGAGCAG 2220

CAGGACATTC TGTCTAAGTT TGGGAAGCCG GAGCTCCCCA GGCAGCCGGG TTCTACAGCT 2280

CAGTACGAGG CTGAGGTGGG GTCTCCAGAG GCTGAGCCCT CAGAGTCGGA CTCTCCACAG 2340

AGCAGCGGCA CTGACGCCAG CCACTTCCTC CACACGCTGG ACTGGCAGGA GGAGAAAGAA 2400

GCAGAAACTG GTGTGGAAAA TTCCTCTCCC AAGGAGAGTC CATCTGCCCC AGTTGCAGAT 2460

GGAGAGGGGA GCGAAGCCTC AGATGAAGAG CAGCAGACCT TCCCTGGTGA AGACACGCCT 2520

GGCCTCGCTG CAGGGACTGA CCAGGGGGAC TTGACACTGC AAGTGGGCTC CTCAGTGGCA 2580

CCACAGGAGC CCCTGCCACA GGAGGAGGGT GTAGACCTCC TGGGGCTGCA CTCAGAGGTG 2640

GACCCAGGGC CAGCGCCCCC CTCGCAGGCC CCCTCCAGCA ATGCAGACCT GCTCAGCCGC 2700

CTTCTTGGAG CACCCAATGG CACTCCAGAG GGGCCCCCGG ACGACCTGCT CCTGGCCAGC 2760

CCAACCCCAC CCCGGAGCAC GCAGAGCACC CTGCCAGGAG GGCCTCCCAG CCCTGCAGAC 2820

CCATTCGACC CGCTCCGGCC ACCAGCAGAC TCTAGCTCGC AGCCCTGCAC TGCGCCTGAC 2880

CTGCTTGGCG AGCTCCTCGG CCCCGACTCC ACAGCAGCAG CTGCCTCACC TGTCTTCCCT 2940

GCCACCCATA GCGCCCCGCC CCCGTCCTGC AATGCAACCT TCCTGCACTT GGGGGGTCTG 3000

CCCACAGAGC CCAGCAAGGT GACAGCCTCC TCCAGCCACC CCGATCTGCT GGGGGGATGG 3060

GACACCTGGG CCGAGGCTGC TGTGCCCACG CCAGCCCCCA TGTCAGCCGC AGAAGGCCCC 3120

CTTTTCTCTC CAGGAGGTCA GCCGACCCCA CCTGGCCTGC AGCCCAGCCA GACCAAACCT 3180

CAGAGCCTGG ACCCCTTCGC TGACCTAGGC GACCTCAGCT CCGGCCTCCA AGGACCTCCT 3240

GCTGGCTTCC CTCCCGGTGG CTTTACTCCG AAGTCGGCCC CTTCTCCCAA AGGCAGCTCC 3300

TGGCAGATGA ACCGGCCACC AGCCCAGGGC ACCTCGTGGC CTCCACAGGC CAAGCCACCC 3360

CCAAAAGCCT GTATGCAGTC GAGACCCCCC TACGCCACTA ACTTCAGTGT GATTGGAGGC 3420

CGAGAGGAGA GGGGCATCCG CGCTCCCAGC TTTGCCCAGA AGCCCAAGGT CTCAGAGAAC 3480

GACTTTGAAG ATCTGCTGTC CAATCAGGGC TTCTCCTCCA AGTCCGACAG GAAGGGGCCA 3540

AAAACCATGG CGGAGATGAG GAAACAGGAC CTCGTTCGAG ATGCGGACCC ACTCAAGTTG 3600

AAGCTCCTGG ACTGGATTGA AGGCAAAGAG AGGAACATCC GTGCGCTGCT ATCCACGCTG 3660

CACACAGTGC TGTGGGACGG GGAGAGCCGC TGGACCCCTG TGAGCATGGC CGACCTGGTG 3720

ACCCCAGCGC AGGTGAAGAA GCAGTACCGC CGTGCAGTGC TGGTTGTGCA CCCCGACAAG 3780

GCCACAGGGC AGCCGTATGA GCAGCATGCT AAGATGATCT TCATGGAGCT CAATGACGCC 3840

TGGTCCGAGT TTGAGAACCA GGGCTCCCGG CCCCTCTTCT GA 3882

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dld+ y+t ri  +sfPae+ e+  +nn+++v  +ld kh ++y +ynl s r y  +k

Q: 404   GDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDAKHPGHYAVYNL-SPRTYRASK  462

         59************************************************.*********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e g+   +aP+l+ l + c++++ Wl +d++nv v+hc  gk    v vca+l

Q: 463   FHNRVSECGWAARRAPHLHSLYTTCRNMHSWLRQDHRNVCVVHCMDGKAASAVAVCAFLC  522

         ************************************************************

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyfsql  170

         + + +++a+ a+++f+++r           Ps +ry++y + +

Q: 523   FCRLFSTAEAAVYMFSMKRCPPG-----IWPSHKRYIEYVCDM  560

         ******************97654.....59*********8876

Domain Sequence
(FASTA)

GDLDISYITS RIAVMSFPAE GVESAIKNNI EDVRLFLDAK HPGHYAVYNL SPRTYRASKF 60

HNRVSECGWA ARRAPHLHSL YTTCRNMHSW LRQDHRNVCV VHCMDGKAAS AVAVCAFLCF 120

CRLFSTAEAA VYMFSMKRCP PGIWPSHKRY IEYVCDM 157

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013